<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15526

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDTAEYDTNTLLITNIASVVFRIYEPCSSDSVMAFASAALDIEYALRQDGHLVLYDALRCFIWHFQVVAKEGCTPINTRTLDSSLDLCGHALALKEQGSLDPASLQKGRPQLQQASHTATSSLSCTSNPDQSQRNAFTPPSQASLHDSDSKPTDNKTEASSIKVVYASFISAIHSSLSWAFCIKTGAVPLNHQTMLLPPEPLEAGYDGEAGEYDPDQPPLLATFKTHLTTTGSLVVGLCLSPCSGLEPLVHQVTATMTLPDTPILAAPFGLWTRQPFHALAEAGTTSLVPSPNTQALSQHGGPNFGDSLWKQACLRVLNLRGVSSSGLAGCYWASLVVSNVKLPSGDEETRRPLALTASAVTMPWPGPLCFRKKTIDVLPTGRVGDTLLSGVQVSHDALGNARGWYNSGPVRDEQLMKRRAERAAAAKELGSADGRASKQSTSASSPGTGRNAGASVASVIYPTPPDGLQLLSGVTPSLDGTLSSPGNTLPAAPPVDIEQVTSAATAVSDMFEVGATSEAKRGRSDANLLGEADTMFGDMDGDMFGDNDITEADFNFFDAQPGAMDLDLPMEDVALGSQTGETSQEVGTELDKAQASGGRAKAVQGHAARDTIVFAKPELKHARSSRNEAAGQRGGDSGSVGTKREPSPFDPHTVFKRVRASLSNVTASNRAAKAFDSVTFDTSLPLIDKKYSQGGQYDYTKSASWATPKVEPGTLPETDYLKRHGRQARKRKESGLDAGSLVRTLTGLEAPICQSTLASLNSMQIDNDGSSDESDEDDSSYTTNEPASPVKSSVKSGTGRLMAHDDDGHDNGDVDGASSNSPNPSPNTVAQADEPDEQLIGELGRLAKEGEAEVPLSLLFSDAEPLNLEISIGDQVFIQVAQIVTQQAAIGSLEICDLADEAMALPDTNLHSQALSVHVRNAQHVLRQVTPWFLAGAEGVNFKGLLDVTDMALVGQQSRLQSRSIPGRDPNAEPVRPSNLYQIPGSHLEVRRSDAKLSALPSAISFWESLGLSPASGSKDVSAVCVFPSWSGMVDNVRCFMECVKSVYEVLKLGSWDSMPLGGHGQQDGILPYQVEVGLAPPEGTNGARASALGQSMQVLREAVCGVEATRPNVVVYFVYSPSTPATIVEACIAFQQLCDVYRRWLAGQGDSQGRKVVLQLVSLRTVSSSSSVVVASARELSKLCMETYDRCAPLGRPAMKLEQPLPRIIDFKLKATPSASLMRENSCMHVAYAQSMDKRWVTAAWTDDGGTRQETASYCLGRKGMALSRSMAEVATEIWETTLGLISECKVHWRIVLTKCSPMEQQEVEAWKELVRNTMHMSVAIVLLTVDSSPSLQLVPPTIKLPSATAALLSTPVSTPQASIMSPEPASGGAMASGTTPGAEGSIGAADAEADAVLVDVTEQTWGAVSGHRFSNPASTTEVKPGQMSGYLVKRTGPRAEDTPVLMEVNLVYADATPRSPETMLREMMSYFRGLGTLARARGVVARETDVRPWHVAVAEKGVRAVYLLM
Length1512
PositionKinase
OrganismOphiocordyceps australis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Ophiocordyceps.
Aromaticity0.05
Grand average of hydropathy-0.225
Instability index44.84
Isoelectric point5.16
Molecular weight161096.43
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15526
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     803.96|     211|     273|     269|     485|       1
---------------------------------------------------------------------------
   90-  266 (190.66/102.10)	...........HAL.ALKEQGSL.DP.....ASLQKG..RPQLQQaSHTA.TSSLSCTsNPDQSQRNAFTPPSQASLHDSDSK.....PT.DNKTeassiKVVYASFISAIhsSLSW..AFCIKTGAV...PLNH..QTMLlppEPLEAGYD..GEA.GEYD..PDQPPLLATFKTHLTTTGSlvvglCLSPCSGLEPlvHQVTATMTlPDT......PILA.................................
  269-  485 (342.96/206.69)	FG..LWTRQPFHAL.AEAGTTSL.VPSPNTQALSQHG..GPNFGD.SLWK.QACLRVL.NLRGVSSSGLAGCYWASLVVSNVKL....PSGDEET.....RRPLALTASAV..TMPWPGPLCFRKKTIdvlPTGRVGDTLL...SGVQVSHDAlGNARGWYNSGPVRDEQLMKRRAERAAAAK.....ELGSADGRAS..KQSTSASS.PGT......GRNAGASVASVIypTPPDGLQLLSGV.TPSLDGTLSS
  545-  760 (270.34/149.09)	FGdnDITEADFNFFdAQPGAMDLdLPMEDVALGSQTGetSQEVGT.ELDKaQAS.....GGRAKAVQGHAA..RDTIVFAKPELkharSSRNEAA.....GQRGGDSGSVG..TKREPSP..FDPHTV....FKRVRAS.L...SNVTASNRA...AKAFDSVTFDTSLPLIDKKYSQGGQYD.....YTKSA.SWAT..PKVEPGTL.PETdylkrhGRQARKRKESGL..DAGSLVRTLTGLeAPICQSTLAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.38|      16|      17|    1434|    1450|       2
---------------------------------------------------------------------------
 1434- 1450 (23.08/16.82)	LV.KRTGPRAEDTpVLME
 1453- 1469 (22.30/10.20)	LVyADATPRSPET.MLRE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.06|      29|      47|     898|     926|       5
---------------------------------------------------------------------------
  898-  926 (48.46/25.25)	DLADEAMALPDTNLHSQALSVHVRNAQHV
  948-  976 (49.61/26.01)	DVTDMALVGQQSRLQSRSIPGRDPNAEPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      77.18|      19|      22|    1348|    1366|       6
---------------------------------------------------------------------------
 1324- 1340 (17.83/ 6.69)	.SVAIVLLTVD.SSPSLQL
 1348- 1366 (30.12/17.49)	PSATAALLSTPVSTPQASI
 1371- 1389 (29.23/16.71)	PASGGAMASGTTPGAEGSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.85|      24|     215|     977|    1004|       7
---------------------------------------------------------------------------
  977- 1004 (33.58/31.28)	RPSNLYQIPgshLEvRRSDAKLSALPSA
 1198- 1221 (44.27/26.14)	RPAMKLEQP...LP.RIIDFKLKATPSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.43|      11|     560|     929|     939|       8
---------------------------------------------------------------------------
  929-  939 (22.23/12.52)	QVTPWFLAGAE
 1492- 1502 (22.20/12.50)	DVRPWHVAVAE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.39|      11|      17|    1404|    1414|       9
---------------------------------------------------------------------------
 1404- 1414 (21.92/12.18)	TEQTWGAVSGH
 1423- 1433 (21.47/11.76)	TEVKPGQMSGY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15526 with Med13 domain of Kingdom Fungi
Unable to open file!