<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15511

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMTSRTPMGVQQRLPQRAIGGSSSASASSSSSTLSHNPQHTSSQQQQQHQHQQQQQQQQHRHPQHQHQHHHHHQQQQQQRNLLSLSQKQHPQSPSRRDPQNHSQQQGSFDQDPSDLALAAQNRYGTLPRHGGSRLKTEVSSDSVVVKPPTEPATISTSMRVIPTSAASTVVPTAASPDGGASSVDSVMTDASTLNPTVAPVDDGPPPLPKRRSRLNRPIQTTQAPARQPAVQTSLKKDTRPRPWAPETPPEAPRFKPGWKPDPALRMDAGSTSIVRATNSGFADFFPWTGNHAEDQMSEQIIRSGYFDKPPSTHPETNTARPTVLPQIKQKTGLTALSTIFASVMAQRRATGQITSTSTFKPPPRVTLTDTKRELWLKDLASPASSLRKLSRTIPHGIRGKSLLEQCLNKKVPIDRAVWLANIRFSTNLYSEGLLDRDHYVDWLVQSLENCPQTKLPIWLLISRIYWADLLKGRKNGKRLVVALLSHLTAIYNDPDGDVLSQLSTNLVVLIKSIILSNPDSFISPSTWFKHKDALYAYLPPGDPAYISALNIINSRNQWLLSSNTTTQSTGRQELVRLLDATMLTPPADVAIQRCWNLANDKPVLAQTLLEWGTSAHRPGFSKVYVAVRFLREGGRMGIDVTSAVLDFIDTIPITANHRKKALYILVSELVRSKDLCVSRYISWLITQGSLSQESQAHPDGPCMTRLLIELPLDSLDESLITSRANLLRRVNFSCKEEAEDIQNALKLAMQSIGMLRTGTLTQEDCPPQSHTSKTLKATKLAIPMRKSSRALQTAIGSAIAQAFEERFLLPDGSPPITVASFTSARILLEAGSDFSKLGVVLRVSTKSTDPEVLACCADTLNANIFCLAALGECRRIYDLLLEAGTSPHIDNTASKRTYFSAMACLATRIPGQEAVAEQFRQKLRMADRNTTIDACSPVSDSMATAINDRDFDLPEEIEKLLANGTVADPSTMDRIFQMIITGLESSWEKEEGDRRRSLALLLSRLRIFDPIRFDARMNEWLRKVMTRQTRPSLNKMFPLIISLGCVELLMVVRAALSEASSCPLPRTNNTFVQEVMQLASINPPSNDVLAPEESYRVHVQQQILLLKNPKELLMLIRAALEEYVSLGGRINLTSEFPLDRKGRWDAIIQQLQSLIIADSNLVSTYLGGKSQNWAMGNLINNLTTRLLLGTDTTQSDISYDDILQQANELTLPFCQLKLSVALTADDPIDENGGEAGLSQIELFTKAMENAIESRHVMWTNALPHHNEDIAQQLKARAQAKFLEVIPSPRNPDDLIRTPEQIQMAETLLSIVDSLSRGRTMRGASQLSANITERLNDLWELLMMEKVPEMAQVRQQILTSWLPAMLKFLLLHASPTDTAPGPSSVPTPTATSSSRLQPSGSSGAQNVRPRLVMILCGILLELDEVSQNEANLAATPEQKVFDVALMLIDGLCDEVRMHCSRTILASLESPGLVNSNRTSDARVRYLFSQANDMPTDSILLGHRDKSLLGPGGRSVALKHAMGQMQTPVLMQTDKLVPFVLRRWEVLSEPTPTVGENDTSISLTLFDAIKLQ
Length1570
PositionKinase
OrganismCeratocystis fimbriata CBS 114723
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Microascales> Ceratocystidaceae> Ceratocystis.
Aromaticity0.05
Grand average of hydropathy-0.321
Instability index50.63
Isoelectric point8.51
Molecular weight173739.25
Publications
PubMed=23931120
PubMed=24563841

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15511
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     100.65|      19|      19|      38|      56|       1
---------------------------------------------------------------------------
   38-   56 (39.54/17.61)	QHTSSQQQQQH..Q.HQQQQQQ
   58-   78 (37.27/16.24)	QHRHPQHQHQHhhH.HQQQQQQ
   88-  105 (23.84/ 8.12)	QHPQSPSRRDP..QnHSQQQ..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     326.83|     107|     136|    1270|    1397|       2
---------------------------------------------------------------------------
 1270- 1384 (156.71/113.80)	AQQLKARA....QAKFLEVIPSPRNPDDLIRTPEQiQMAETLLSIVDSLSRGRTMRGASQLSANItERLNdlweLLMMEKVPEmAQVRQQI.LTSWLPAmLKFLLLHASPTDTAPGPSSV
 1403- 1514 (170.12/113.25)	AQNVRPRLvmilCGILLELDEVSQNEANLAATPEQ.KVFDVALMLIDGLCDEVRMHCSRTILASL.ESPG....LVNSNRTSD.ARVRYLFsQANDMPT.DSILLGHRDKSLLGPGGRSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.86|      39|      42|     372|     413|       3
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  372-  413 (54.84/45.62)	RELWLKDLASPAS..SLRKLSRtIpHGIRG..KSlLEQCLNKKVPI
  415-  457 (63.01/37.76)	RAVWLANIRFSTNlySEGLLDR.D.HYVDWlvQS.LENCPQTKLPI
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     241.37|      87|     136|     509|     600|       4
---------------------------------------------------------------------------
  509-  600 (141.55/102.19)	LIKSIILSNPDSF..ISPSTWFKH...........................KDALYAYLppgdPAYISALNIINSR.NQWL.....LSSNTTTQSTG...RQELVRL....LDATMLTPPADVaIQR....CWNLAND
  608-  740 (99.82/59.68)	LLEWGTSAHRPGFskVYVAVRFLReggrmgidvtsavldfidtipitanhrKKALYILV....SELVRSKDLCVSRyISWLitqgsLSQESQAHPDGpcmTRLLIELpldsLDESLITSRANL.LRRvnfsCKEEAED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.46|      12|     136|    1024|    1087|       5
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 1047- 1058 (21.16/43.26)	ELLMVVRAALSE
 1111- 1122 (21.31/27.54)	ELLMLIRAALEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.19|      20|     774|       6|      26|       6
---------------------------------------------------------------------------
    6-   26 (32.24/27.57)	PMGVQQRLPQRAIgGSSSASA
  783-  802 (34.95/23.92)	PMRKSSRALQTAI.GSAIAQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.71|      19|     136|     219|     239|       7
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  219-  237 (31.63/16.18)	QTTQAPARQPAVQTSLKKD
  243-  261 (37.08/14.23)	WAPETPPEAPRFKPGWKPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      87.61|      18|     774|     309|     327|       9
---------------------------------------------------------------------------
  147-  162 (24.83/ 8.52)	PP.TE...PATISTSMRVIP.
  309-  326 (35.45/17.31)	PPSTH...PETNTARPTVLPQ
 1083- 1102 (27.34/10.60)	PPSNDvlaPE.ESYRVHVQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.77|      14|      22|     166|     179|      11
---------------------------------------------------------------------------
  166-  179 (26.27/15.48)	ASTVVPTAASPDGG
  190-  203 (26.50/15.69)	ASTLNPTVAPVDDG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15511 with Med12 domain of Kingdom Fungi
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