<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15506

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMETGDCATNTLVVDNIASINYRLFNLVPESKRTQGITAQGLEKSARDAGHIVLFDSRRRALWHFQTVHKDSKPLQPQQAALTPLESLEFSGFSLSLLGLGSYEPSSLAKSRLGPGAAVGSAQQQQQQQQQQQQQQAQDLSNAKSSDSPSLAISAFEAHPLFITALQGTLNTAFAWHVGAIPLNDRTLLIPSDKSSIYDSQASSTATATIQAYLTTAGALLVSISVTVHEGLRLLDKAMTYNHSIADCAVVLAPFGYPGRLRSPDGGIDALLAHTPYTPAFKQPDNKTNKWRLMISTLLRVRGIPPSVIDNAPWVDIQLGPSEPSDPKGLGRQGYMVQWPLKLCIRRRMVCLPPQPLEDEENDYDALNIAKSWFQEAPTRAEKVARRKTEREAQASMDSDSKHGSQHNLQLTHQMHHQQGTSQTQQLQPQQSHSQSSHQMLGLSAQSPLNNAIPRPGLNSNNAMYPTPPDGIQGQTIGLLTLAEDALSSPANASSTVAIAGSSTTAMDLWTSGPSMPIGGFNGSAVGSDAKMLGDSSGGGIEIADVHLNFFDDKTLDSTDGVSGAFSPIQSTSRRLSHSGQMQPPPLPNQTQSQLQNSNLSCSNLDSGSHLPTPSMPPPPDFVSIKKQSPDSETPVFTKPELRHARSMGDTMRQNVSQGRPRSVSFLQSTGNRLKRGASPFGPDAVYKRLRAVVPQAALPLHSASVRKGNVFDKVSFDSSLPAVNSKYAEGGIFSVDRKPVKRSLSFDTSAPPTTGYLRTHGKHRKVSKPYPFVAAPNAPPATCHNNNNSLVLHVTKAMENSSLTNSPTRLGGMEEELQSDADDVSDASDMDDTSMSSDELTSPIKINGPRRPGDELSARGTPGRDSEDTECNSAMEPGNLSRIPSPGWIMSRFLAESEPLPLYPQLSGEDLVAIAQVVTEQASTGILKIYTDAQKGLEPASTQNLRRKSSLLARQAVQTLIKVFPKSFRSPAQLSLKSLADTQDLASLQQAQAQAHVQANAQANSQQQRGALRPGSQARETERPPLLFTIMPSHLEMRRAESRLSILPTAVAFWESLGLGPCKGTKDIRAVCLFPGYSGLSDDVRCFLDRLKILYESLKLGSFETLTSNPGIEDGLVVYDAGWNSATTFATAFPNISPSLAERSSAICDALEASTEVGKNFVVFFVYWPSNPATIIEACHTFYRLHEAYRLSLEATGKFPNNELVLQLIPVDTISAPLSVVTPQPSDLSRLCIETYDRCSIFNQPMPAPSILLDEPVQRSSIEFKTSAPSESILHENSSIHVAYAKSLDNRWISIAWTDSRGLQQQTASYCLIRKGVRGQGMQWNDIAQDIWQATIELMAVWKVCWRVVISKCGAMDPSEVEYWTQLAQNETRASFYLVLLAVDTSPALQLLPKAVQLSASVQSATYATPAGTPQASTPEVASTPRATADGPSTTPTPSTVDVTSDPDGDGVLIDVAEQTWGIVLSHRLNNSMMPARQNLAMASGYLVKRGGMRCEDPPAVLEVNLVWLDGVARGVDPMLREMLKQFRGLGTLARARGVTEQWDVRPWHIAAAEKGVRTLYALL
Length1564
PositionKinase
OrganismCeratocystis fimbriata CBS 114723
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Microascales> Ceratocystidaceae> Ceratocystis.
Aromaticity0.06
Grand average of hydropathy-0.341
Instability index54.96
Isoelectric point6.33
Molecular weight169627.26
Publications
PubMed=23931120
PubMed=24563841

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15506
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|    1066.79|     265|     574|     298|     574|       1
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  122-  270 (112.51/57.42)	....................................................................................................................................................................................................................QQQQQQQQQQQQ.QQaqdlSNAKSSDSpSLAISAfeAHPLFITALQGTLNTAFAWH...........V....GAIPLNDRTLLIPSDKSSIYDSQASSTaTAtiqAYLTTA...GAllvS......ISVTVHEG.LRL.LDKAMTYN.................HS.....IADcaVVLAPF.........GYPGRLrSPDG.GIDAL
  298-  574 (447.23/289.18)	LRVRGIP.PSVIDNAPWVDIQ.................................................LGPSEPSDPKGLGRQGYMV..QWPLKL...CIRRRMVCLPPQPLEDEENDYDALNIAKSWFQEAPTRAE....KV...ARRKTER...............................EAQASMDSDSKHGSQhnlqlthqmhhQQGTSQTQQLQP.QQ....SHSQSSHQ.MLGLSA..QSPLNNAIPRPGLNSNNAMYPTPPDGIQGQTI....GLLTLAEDALSSPANASSTVAIAGSST.TA...MDLWTS...GP...S......MPIGGFNG.SAVGSDAKMLGD.................SSGGGIEIAD..VHLNFFdDKTLDSTDGVSGAF.SPIQ.STSRR
  605-  872 (257.13/148.88)	DSGSHLPtPSMPPPPDFVSIKkqspdsetpvftkpelrharsmgdtmrqnvsqgrprsvsflqstgnrlkRGAS.PFGPDAVYKRLRAVvpQAALPLhsaSVRK.............GNVFDKVSFDSSLPAVNSKYAEggifSV...DRKPVKR...................................SLSFDTSAPPT.................TGYLRT.HG....KHRKVSKP.YPFVAA....P..NAPPATCHNNNNSLVLHVTKAMENSSLtnspTRLGGMEEELQSDADDVSDASDMDDTS.MS...SDELTS................PI.KING.PRRPGDE..LSA.................RGTPGRDSED..TECN............................
  876- 1143 (249.92/144.69)	..........................................................................EPGNLSRIPSPG......WIMS.......RFLAESEPLPLYPQLSGEDLVAIAQVVTEQASTGIL....KIytdAQKGLEPastqnlrrkssllarqavqtlikvfpksfrsPAQLSLKS.....................LADTQDLASlQQ....AQAQ.AHV.QANAQA..NSQQQRGALRPG..SQARETERPP............LLFTIMPSHLEM.RRAESRLSIL...P.TA...VAFWESlglGP...CkgtkdiRAVCLFPGySGLSDDVRCFLDrlkilyeslklgsfetlTSNPGIE..D..GLVVY..DAGWNSATTFATAF.PNISpSLAER
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15506 with Med13 domain of Kingdom Fungi
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