<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15501

Description Mediator of RNA polymerase II transcription subunit 8
SequenceMASLKVSPDELRALDQARQRFMQLSNSIGSLKMDVHNANPLPSLASLHATEDIIFKDLTSLHDLIDQNSDLFQRLSVHPSTNFPGRTHENVLMQLIRKKLEPDVEELVEQGRVRGATVSAGPDGENPNGASSNGATNNAGGSAPPFNPSNNMIAAARTESINAEQLSELLNMWSEIRSWLTKRVVMYATQEAQELFTAAEKEAGEESARTGLQHSLDWDSEDEDADEETDQSARRHKPEVFVDPERVLSFCFKLDPEMPANFDFESRRPKTKTNALPRR
Length279
PositionHead
OrganismCeratocystis fimbriata CBS 114723
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Microascales> Ceratocystidaceae> Ceratocystis.
Aromaticity0.05
Grand average of hydropathy-0.686
Instability index47.82
Isoelectric point4.94
Molecular weight31096.14
Publications
PubMed=23931120
PubMed=24563841

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364144
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP15501
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.89|      16|      18|     115|     132|       1
---------------------------------------------------------------------------
  115-  132 (24.86/19.92)	GATVSAGpdGENPNGASS
  134-  149 (32.03/18.16)	GATNNAG..GSAPPFNPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.75|      15|      19|     200|     214|       2
---------------------------------------------------------------------------
  200-  214 (24.52/13.99)	EKEAGEESARTGLQH
  222-  236 (25.23/14.57)	DEDADEETDQSARRH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15501 with Med8 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EAQELFTAAEKEAGEESARTGLQHSLDWDSEDEDADEETDQSARRHKPE
2) ELVEQGRVRGATVSAGPDGENPNGASSNGATNNAGGSAPPFNPSNNMIAAARTES
191
106
239
160










Molecular Recognition Features






MoRF SequenceStartStop




NANANA