Description | Mediator of RNA polymerase II transcription subunit 11 |
Sequence | MEPQEPDHVFTPADRIRQLNDIDKDVTKLLNAAGVAISSLTNPSSITARQPYNDLPKIDGALEAHQAAFKAASSQYFALLSSIDVRLRRQVYALEEASIIKPESAETAGGGTTTTTATASSGGVNPLDTSWLNSRKDTVGKDKEADLWAEASKFATQLEKVKGAYRNESGGVDKNGTSEENMEVD |
Length | 185 |
Position | Head |
Organism | Emmonsia crescens |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Emmonsia. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.564 |
Instability index | 27.98 |
Isoelectric point | 4.86 |
Molecular weight | 19872.67 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364147 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP15492 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 63.26| 17| 46| 121| 137| 1 --------------------------------------------------------------------------- 121- 137 (32.42/21.40) SGGVNPLDTSWLNSRKD 169- 185 (30.84/20.06) SGGVDKNGTSEENMEVD --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) ITARQPY 2) KDKEADLWAEASKFATQLEKVKGAYRNE 3) LNSRKDTV | 46 141 132 | 52 168 139 |
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