<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15490

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPAGALTNFRAIDGFFHIFWRIYSRVAPESPESQFDSLESPALRNSNEIRGSLLALRNIGCLVSQLANRSDLWIFSTNPNFDALGQVSRKQKPGEDLIVAGNITFLNAASGVNTAPEIKRRLLSDPESSIFYQAPTQNKLTPSFSENSQLQGLATYSAFYEAFISATSTALTLHFTKQQKVIPLGTRTLYSSLHENGYQSGEDDSPCARESISFLSTLDINMTSKGRLVISLSTLPQPGLEQLHHDSESDITATCLNDDLWLAPSGILCRLTSIDEGLIGTTPHGSELPTGNINANKREWKRTVTEWLKLFGLYLNDPETEFWVGVEVNTLDRPFCDTFPKSTLNHQTASPFIQILWPAKLCFTRSRSKMTVPINPTEFFSGQAESPLQFAERWVSEPFPISQPFDKHKTSDDSSELEKQQLKRSELSPLRLDRSDIPESLARAINLREAHLASAVYPTPPGGALTQNIGVGIVSEGLGTSTIDALNYPPAQSESIYNEASGLSTYFRGNSELLPTGLDAASSELGIGSGLYDTAADEDFFGDMDVANFDTKGITEADFNFFDEPDFAGLTGDLDMQTGELETLQQHAESNLATPYNSHTAMSIAEPDLSNAGQSHPPTTSNGDASTKHSAVTSLIETAAEGQISGGTADLGQIIPTDGPRRRPISPPLSPVQIKKILSPDVSSLLKSKSLKSEISKPRPVQNQYSPVIFQPKLWSSDKKYRMDGRFWFTPGRGLITSNLGSYPSDIPTIGFPEKGRKARPKPPPIHISPSPLVSDNAPETELQSPSASSSDSSDDGSNTDRGSNASSPHITSFHSKRKRDYEGGGNSTPSSLERITQASDVDNGRLNEHQLMLLGGFLSEVVDWPLTGYFSRKQNDVFPVFTRKEDLLQAAQLVVDQITQSSLRHIRDDLHKPEWADWDDVLSRSLFNNSDCLGHMSKLDLRTYATLEDGPNSRKDMPSIRPNIAGSICKICSPHIKVHRGNSYLEVLPPATGFWETFGLEPLQGEKNIIPFCIYPPNVTEAADAFMERLGLVYSSGNFGSHSRPNKANGLVPWSLNAASDQDYASLMHALNVSCENLGSALSNISATDENVVIYIINPFVYDAAIVDICSAFLRLFHKYIGDVDRQHTRRLNELVLQIIPLEFVASPDSLVVPTQMEYLRLALEVYSRCPPKDRSSDWLGCAPPLVLADPVPKVVPFRLASEPVAPLEEAKCLHVAYSQSVDQRWVTAAWTDNSGRHQTTLSYCLRERDSPVSRPISEIRAQIWETSKDIMDMSSSHWRLMVVKDEPIGSEEVGMWKSLLDQYNRNKAIKVELGIVCVNTKPGLSLKLPSSPLQLSALSQQSTQNGPSTTTPGSTPRPVPSPDPSGPAATPPTANTPMFTDQQQPPPQQTPQPSPDPDQDTILIDKSDETWGVTLSHRLNNSYSLTKYQPALASGYLFRRSGTSDMDGQAVMAVNLIYTNSRRPIDHLLKDILRMYRELATLARARGIVHVQGNSSLPWHIMTAVKGQEVLCYTL
Length1519
PositionKinase
OrganismEmmonsia crescens
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Emmonsia.
Aromaticity0.08
Grand average of hydropathy-0.392
Instability index54.70
Isoelectric point5.33
Molecular weight167168.62
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15490
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     371.61|      93|     364|     218|     310|       1
---------------------------------------------------------------------------
  218-  310 (159.45/95.99)	STLDINMTSKGRLVISLSTLPQPGLEQLHHDSESDITATCLNDDLWLAPSGILCRLTSIDEGLIGTTPHGSELPTGNINANKREWKRTVTEWL
  328-  401 (115.70/67.34)	..............VEVNTLDRPFCDTFPKSTLNHQTASPFIQILW..PAK.LCFTRSRSKMTVPINP..TEFFSGQAESPLQFAERWVSEPF
  405-  471 (96.46/54.75)	QPFDKHKTSDDSSELEKQQLKRSELSPLRLD.RSDIPES.......LA.RAINLREAHL.ASAVYPTPPGGAL.TQNI...............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.69|      24|      40|    1140|    1168|       2
---------------------------------------------------------------------------
 1140- 1168 (35.14/37.43)	LQIIPLEFVASPDSLVVPtqmeyLRLALE
 1183- 1206 (44.55/31.46)	LGCAPPLVLADPVPKVVP.....FRLASE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      91.76|      27|      29|     520|     547|       3
---------------------------------------------------------------------------
  493-  514 (17.86/ 6.14)	...AQSEsiYNEASGLstY.......FR.........GNSE
  520-  547 (47.00/32.91)	LDAASSE..LGIGSGL..YdTAADEDFF.........GDMD
  551-  577 (26.89/12.94)	FDTK......GI........TEADFNFFdepdfagltGDLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.28|      12|      36|    1356|    1367|       4
---------------------------------------------------------------------------
 1356- 1367 (26.27/13.17)	PGSTPRPVPSPD
 1391- 1402 (27.01/13.80)	PQQTPQPSPDPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.13|      15|      36|     663|     683|       5
---------------------------------------------------------------------------
  663-  677 (27.98/ 6.07)	RRRPISPPLSPVQIK
  699-  713 (28.15/10.51)	KPRPVQNQYSPVIFQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.53|      21|     621|     190|     214|       6
---------------------------------------------------------------------------
  192-  214 (30.61/26.79)	YSSLhENGYQSgEDDSPCARESI
  947-  967 (39.92/17.97)	YATL.EDGPNS.RKDMPSIRPNI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.08|      14|      38|    1029|    1044|       7
---------------------------------------------------------------------------
 1029- 1044 (21.12/24.42)	FMERLGLvySSGNFGS
 1070- 1083 (25.96/19.86)	LMHALNV..SCENLGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.12|      12|      15|     771|     782|       8
---------------------------------------------------------------------------
  771-  782 (22.22/11.49)	SPSPLVSDNAPE
  787-  798 (20.90/10.29)	SPSASSSDSSDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.17|      24|      30|     587|     616|       9
---------------------------------------------------------------------------
  587-  616 (33.26/35.22)	QQHAESNLATPynsHTAM.SIAE...........PDLsnaGQ
  620-  655 (27.91/13.87)	PTTSNGDASTK...HSAVtSLIEtaaegqisggtADL...GQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     287.92|      93|    1205|      41|     145|      16
---------------------------------------------------------------------------
   41-  145 (145.25/107.87)	ESPALRNSNEIRGSLLAL.RNIGCLVS...QLANRSDLWIFSTNPNF..DALGQVSRKQKPGEDLivaGNITflnaasgVNTAPEIKRRLLSDP.ESSIFYQAPTQNklTPS
 1253- 1352 (142.66/82.68)	DSPVSRPISEIRAQIWETsKDIMDMSSshwRLMVVKDEPIGSEEVGMwkSLLDQYNRNKAIKVEL...GIVC.......VNTKPGLSLKLPSSPlQLSALSQQSTQN..GPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.61|      28|      31|     864|     891|      17
---------------------------------------------------------------------------
  864-  891 (49.67/29.81)	VVDWPLTGYFSRKQNDVF.PVFTRKEDLL
  897-  925 (45.94/27.01)	VVDQITQSSLRHIRDDLHkPEWADWDDVL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15490 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LPSSPLQLSALSQQSTQNGPSTTTPGSTPRPVPSPDPSGPAATPPTANTPMFTDQQQPPPQQTPQPSPDPDQDTILIDKS
2) LTGDLDMQTGELETLQQHAESNLATPYNSHTAMSIAEPDLSNAGQSHPPTTSNGDASTKHSAVTSLIETA
3) NLGSYPSDIPTIGFPEKGRKARPKPPPIHISPSPLVSDNAPETELQSPSASSSDSSDDGSNTDRGSNASSPHITSFHSKRKRDYEGGGNSTPSSLERITQASDVDNGRL
1332
572
741
1411
641
849










Molecular Recognition Features






MoRF SequenceStartStop




NANANA