<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15487

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMEESFPLPLRPFIQKSAAEPDSLPIRIAQINAQRGSFRNVTEQSLQEEIDAQRALEAAGGEAEEKGEVESEEVKPTDRLEQLFKSRAEIIDFAAQAHAEANYALDLVSLLVSKYTPRQAEVSMSPYLKQRAPLGSLGIDVIKTPEKTEAAQKEIVDLSRGWKLENFDAAANKLLQSASRLEEEVAAETKYWAGILDIKEKGWKVCRLPRERQTLGVQYGFLEATPTFRDRGLAALRRGAGGDLILDRGLQTSKPRSLRVRVQHDDQIIGVSKLIPLELAAGEDAIESRIRLARDALYEEELFHEINREARTLLQHGIESKQNLIQFQANDNQQILIDLVGLDEGISDSDQQGHEEDALAETVAQSLRLLLSHAHRQKYRRRTQIPPPVTAKRRPNPEYSLLQPTVSYLQHKSAIRWLRSFLDTITRTLQLAGLKCKYDIAPLISVKLPLSPKTTAPAPAPSSEPDSPPFVERLVDSFLTPLESIVTGTFLSPTSSFKIRIITTINPNALGTEFEIATNISSGPRTRTSSSRFGLRDDLQQLLLYLFTTDLVYLIPHLARDTDIQSSPPPVTSGQKQEQEPTEETGFNTPTPSHPSHLTPWTPTSPENGELTAFSPAQRRSKKLTIDLRPDRLAIQCQWLGGSEPDVEAEIDFERAVGGGVTGGVEVKGAPSGIMMYSWGDGGGGVDEERTLRDVIGLISQENLC
Length704
PositionHead
OrganismEmmonsia crescens
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Emmonsia.
Aromaticity0.06
Grand average of hydropathy-0.443
Instability index55.64
Isoelectric point5.29
Molecular weight78042.13
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364140

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15487
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     294.19|      93|     174|     380|     487|       1
---------------------------------------------------------------------------
  380-  487 (143.77/104.22)	RRTQI...PPPVTAKRR....PNPEYSLLQPTVSYLQHKSAirWlrsfldtiTRTLQLAGLKCKYDIAPLISVKL..PLSPKTTAPAPA..PSSEPDsppfVERLVDsFLTPLESIVTG
  559-  662 (150.42/79.11)	RDTDIqssPPPVTSGQKqeqePTEETGFNTPTPSHPSHLTP..W........TPTSPENGELTAFSPAQRRSKKLtiDLRPDRLAIQCQwlGGSEPD....VEAEID.FERAVGGGVTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.94|      14|      38|     232|     247|       3
---------------------------------------------------------------------------
  232-  245 (22.66/11.77)	LAALRRGAGGDLIL
  273-  286 (21.29/ 6.64)	LIPLELAAGEDAIE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.47|      24|     231|      84|     109|       5
---------------------------------------------------------------------------
   84-  109 (34.91/27.18)	KSRAEIIDFaaQAHAEANYALDLVSL
  318-  341 (40.56/25.49)	ESKQNLIQF..QANDNQQILIDLVGL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15487 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EAEIDFERAVGGGVTGGVEVKGAPSGIMMYSWGDGGG
2) EIDAQRALEAAGGEAEEKGEVESEEVKPTD
3) TDIQSSPPPVTSGQKQEQEPTEETGFNTPTPSHPSHLTPWTPTSPENGELTAFSPA
647
48
561
683
77
616










Molecular Recognition Features






MoRF SequenceStartStop




1) FPLPLRPFI
2) LPIRIAQI
5
23
13
30