<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15485

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGIIMDGTSAIGLGRENDRQHVDSILSTTTSLAPHNNGNYSNGSFHAKDATHLPNSSFDDSLPPELVHISHGFFSLGHLINRASQQCWNDLTDLIAELADPQTTALNATSHAAAAPITTTNGKYTPSQSAAENAQRKLRILEFAQAKRADFIKILVLSQWSRRAADVSRLIDIQAFIRMRYDCYNGAILSIGEMKRDLIRAQTANPDLAMALEILSTGKVAAMQERSFVPPTPLTPKMMLKTLKKINKTIRTRLVLHDQIPSAFKNYFVHDGRVTFKVPTEFEVDLSIAQESHSSQFFFVDIRFLFSPSPPKPTGRLLDELDNRVNAMLMRSGLTGCYNLLHNLVLSNKITILFHQAIELARGHWLDTLRVEVLHRTLVVQYWINRPGPKSWIEIGVKSGRRKDEIQDGSTTESPFLGLRWMRDNKEVESRNIKFDPELLSMEAILRSVTALHISFLLQSTYARLSQGRLYASGALSVSLQTSMSEPGDCFFDVQLTKGRNLRVMIEPVSGAIIFRPTPLLLNRHDIDRSFERPIIDDMLFRISRLRSAAVIEEVESLADALMWETVNSRDIKGEDLRRIFPPNILRSVLFFRKSWECNWGVAYTCSMDGDNWWVVELRAPSNDKGPFSPQSARMVTGRFGGLPERLNYGSFGQLDHALSGMLAIHANARYLSELHGIHHFPPMRNLCLGPHLQVPSVFIRFRSGSLPAALQISPSIATNKNSAIRDTVRLSFRGIDPSSQCAILLAHGHLSREINDLGLLVVHLDPTITFQPNGCGFAMRFLTPVGQPMIIQLLARLQQLERIISTLETLKQKSLKPLSVSLSRIKFSYATDEDAVASINFNYHEQAIASDIDSLTLLSKQTPLMLLRMSIDFHPQNPHRRIKESLTTTLNGLRPGAGAGAGLEAVLQLLVITLPILKGLDRISTDLHTSGRPGNYGLQIIARSSKIFHLRYPSIRYRFCIHAGLRRDRVVWILKDMTTASDKTGRESLENKLKEQIYNVHGDGWQGLDTGAIADCENIGNLLSTLHGIVAEYISSETGCGLGSNNMGSRNGSSGGGAGGSSGGGGSGPEGQKALQTYPAGRGAADNKPKPKPGQAGMGMGMQGRPGGLGGTKGPTAANNGMAMATQAETQTQSDTKAATQNTKSAQYNNNNNNATRTMANGNGNSNGRDVDFIMID
Length1179
PositionTail
OrganismEmmonsia crescens
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Emmonsia.
Aromaticity0.07
Grand average of hydropathy-0.250
Instability index41.74
Isoelectric point9.22
Molecular weight129860.75
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	ARBA:ARBA00003669
ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15485
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.74|      28|      47|    1062|    1090|       1
---------------------------------------------------------------------------
 1062- 1089 (53.05/29.15)	GSSGG.GGS.GPEG.........QKALQTYPAGRGAADN
 1106- 1144 (34.69/13.05)	GRPGGlGGTkGPTAanngmamatQAETQTQSDTKAATQN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     147.35|      47|      47|     496|     542|       2
---------------------------------------------------------------------------
  496-  542 (80.00/61.73)	QLTKGRNLRVM..IEPVSGAIIFRP.TPLLLNRHDIDRSFERPIIDDMLF
  543-  592 (67.34/50.56)	RISRLRSAAVIeeVESLADALMWETvNSRDIKGEDLRRIFPPNILRSVLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     137.83|      25|      46|     303|     327|       3
---------------------------------------------------------------------------
  227-  252 (25.18/11.26)	.RSFVPPTPltPKMMLKTLKKINKTIR
  253-  276 (35.48/18.83)	TRLVLHDQI..PSAFKNYFVH.DGRVT
  303-  327 (41.91/23.55)	IRFLFSPSP..PKPTGRLLDELDNRVN
  351-  373 (35.25/18.66)	ITILFHQAI..ELARGHWLDTL..RVE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.00|      23|      55|     857|     879|       4
---------------------------------------------------------------------------
  857-  879 (42.62/26.06)	LTLLSKQTPLM..LLRMSIDFH....PQN
  909-  937 (30.38/16.59)	LQLLVITLPILkgLDRISTDLHtsgrPGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.82|      46|      55|     629|     683|       5
---------------------------------------------------------------------------
  635-  683 (74.48/68.14)	RMVTGRFGGLPE.RLNYGSfGQLDHAL..SGMLAIHANA..RYLSEL..HGIHhfP
  687-  739 (63.34/34.16)	NLCLGPHLQVPSvFIRFRS.GSLPAALqiSPSIATNKNSaiRDTVRLsfRGID..P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.68|      11|     151|     894|     904|       6
---------------------------------------------------------------------------
  894-  904 (22.38/11.13)	GLRPG.AGAGAG
 1050- 1061 (18.31/ 7.74)	GSRNGsSGGGAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.06|      18|     341|     461|     481|      10
---------------------------------------------------------------------------
  461-  481 (25.81/21.90)	STYARLSQGRLyasGALSVSL
  807-  824 (30.25/16.83)	STLETLKQKSL...KPLSVSL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15485 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GLGSNNMGSRNGSSGGGAGGSSGGGGSGPEGQKALQTYPAGRGAADNKPKPKPGQAGMGMGMQGRPGGLGGTKGPTAANNGMAMATQAETQTQSDTKAATQNTKSAQYNNNNNNATRTMANGNGNSNGRDVDFIMID
1043
1179










Molecular Recognition Features






MoRF SequenceStartStop




1) RDVDFIMID
1171
1179