<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15484

Description Mediator of RNA polymerase II transcription subunit 10
SequenceMAPVTLNGIDNDLKDVIQHLFEIQSAVHGYLGPETQQELVRKIKSLTHSLSTLSEHSRPDPSASPSETTLRINDPDPPLQSVQLPPEIIDYVDAARNPDIYTREFVELVQRGNQDLKGKAEAFASFRDILAREMASAMPECKGEVERVLRATGGSASGAAYAPDGGLDGVMSGGRPGNGDNNENGGGS
Length188
PositionMiddle
OrganismEmmonsia crescens
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Emmonsia.
Aromaticity0.04
Grand average of hydropathy-0.528
Instability index42.17
Isoelectric point4.74
Molecular weight20096.02
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
kinase activity	GO:0016301	IEA:UniProtKB-KW
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15484
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.86|      12|      14|      49|      61|       1
---------------------------------------------------------------------------
   49-   61 (18.10/12.36)	SLSTLSEHSrPDP
   66-   77 (22.76/11.20)	SETTLRIND.PDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.60|      17|      19|     148|     166|       2
---------------------------------------------------------------------------
  148-  166 (25.21/18.33)	VLraTGGSASGAAYAPDGG
  170-  186 (30.39/16.10)	VM..SGGRPGNGDNNENGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.86|      11|      18|      18|      28|       3
---------------------------------------------------------------------------
   18-   28 (19.94/16.44)	QHLF.EIQSAVH
   37-   48 (13.93/ 9.75)	QELVrKIKSLTH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.91|      19|      27|      99|     121|       4
---------------------------------------------------------------------------
   99-  121 (26.33/27.68)	DIYTREFVELVqrgnQDLKGKAE
  128-  146 (33.57/22.42)	DILAREMASAM....PECKGEVE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15484 with Med10 domain of Kingdom Fungi
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