<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15481

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPMIMEDSIDVDDLFGDPTSLELGLEGTASTIKGLPQRLDELRLSGCSQKVAWSKLGAITYVSQDGQKVLLRYLHCRPDDGKWTLSEEAPINQVADVHGGHTIAHLLWNESGSELAIVDSCGRISIATILSTLNTINFARQSSMDPDDDWAQPVGLMWLNANRPLFGFHKATRTNDRWNYPAYRRRPLGPLHPVNKPGLALVTKSGHIKLIYQNPDMRWAEVSTELNPVGYLDGLLTHAAMAPAEGSGISIATHSACGKICFYRVQVKWDPPEWDQTPKPGGGPSNVFPTPSFQVLHTKTEILSTVFHPPVHDVDNITGFSPANGAIYNLTHLEIITAPQVLPGTQSATGPCILAVASMPAQNQHGQPPPSGPSSVLVRWQLDTMAQALHPSFDDVVSKKTASNPKSKIAFRRLDDIYFDRFVISIDYTEAGSVLAITHDDSSISFFEARSMRPINENEDVNIVTSMPNAGFTFPIDASGSLHIAFSPSGCLAVVFDGEWQLHLRYMEHSFGMEDGMYDNGKFTCAIAALALGYVRACGTDTSADDILTVVVRQLNPDAQRSFVTEVYSILFTSVDFTEQDKLVNNQSIQKGLSMQAVLGFRSRFQPRAPSSAVPWIILNIRQIMMLVLTFSHYLKSGRDSTHSEPEVLRMILGNVKWILDLAKYLVDDLLEIADTLPADRNSFSLSSKTYESPSLILILSSVPRSFLRHIFRYLSRFPFTFKAANNLSGESYQLFASINNAIEQSSLKTDVCEKMLAHIDSLVTRSYQAAGFGNAERNAPEREMLITCSIPPVLQSAVTSILTETMPLIVRPEVDRMALALYDYSWLGIGDDKRTELFKRTHDVDILKRNVGRLLDPTVAKRRCVRCCEISEDVSFPRSVSMYRWIVKIGVLRTCVCGGSFAMENVEGLDRVPFPVYR
Length919
PositionTail
OrganismEmmonsia crescens
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Emmonsia.
Aromaticity0.08
Grand average of hydropathy-0.108
Instability index49.56
Isoelectric point5.91
Molecular weight101928.21
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15481
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     350.96|     112|     432|      45|     251|       1
---------------------------------------------------------------------------
   45-  168 (181.36/165.74)	SG.CSQKVAwsklgAITYVSQDGQ.......KVLLRY........LHCRPDD..GKWTLSEeaPINQVA.....DVHGGHTIAHLLWNESGSELAIVDSCGRISiATiLSTLNTINFAR.QSSMDPDDDWAQPVGLMwlnANRPLFGF
  252-  283 (21.68/48.14)	.........................................................................................................AT.HSACGKICFYRvQVKWDP.PEWDQ........TPKPGGG.
  349-  472 (147.92/52.94)	TGpCILAVA.....SMPAQNQHGQpppsgpsSVLVRWqldtmaqaLHPSFDDvvSKKTASN..PKSKIAfrrldDIYFDRFVISIDYTEAGSVLAITHDDSSIS............FFE.ARSMRPINE.NEDVNIV...TSMPNAGF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     276.55|      92|     163|     559|     659|       2
---------------------------------------------------------------------------
  559-  659 (139.11/110.21)	AQRSFVTEVYSiLFTSVDFT.EQDKLvNNQSIQKGLSMQAVLGFRSrFQPRAPSSA...VPWiilniRQiMMLVLTFSHYLKSGRDSTHSE.......PEVLRMILG..NVKWI
  724-  828 (137.43/83.64)	AANNLSGESYQ.LFASINNAiEQSSL.KTDVCEKMLAHIDSLVTRS.YQAAGFGNAernAPE.....RE.MLITCSIPPVLQSAVTSILTEtmplivrPEVDRMALAlyDYSWL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.78|      26|     192|     660|     720|       3
---------------------------------------------------------------------------
  226-  251 (46.19/16.46)	LNPVGYL.DGLLTHAAMAPAEGSGISI
  660-  686 (39.59/89.27)	LDLAKYLvDDLLEIADTLPADRNSFSL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15481 with Med16 domain of Kingdom Fungi
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