<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15476

Description Uncharacterized protein
SequenceMIPHPSSHRPPSRPAPPSRRPSAPSVLYAAPDPPPAIDSRSQQNAVIDLTDSDCGDMADVGRPAKRLRLDTGNEHPSPSLDHHHHNQYQQQQYQNQNQNQPNPQHHGSSTASEAPESSMNPLDLMSASSTEQAVRPPWSFRSDIPRSGAGGPPEPSQWPQSGSLPPLPIRPWKYGPQERYLASTTKPKDGMECGEVKTIPYRIDIPSVAPRFADKKPADFAPWTGSHPEDVLSEQTAKQGFYDRVQVSSNESASARSSLYSQLKHRSGLKLLSSVFTAALEKRQAQCTVTAASTFRPPPRVTLTDIKREAWLRDLANPSVPLRRLSRTIPHGIRGKVLLDQCLGKSIPICRAIWLAKCVGANELRAFKRKGTSAGVASGLETKWVRDWTISVQQFIEGVIASFGDASWRLKISYSIRLSARLFLEHLIEQDHFLDWFLTSLDNASLEHLPVWLLMVGVYWQNIVRYRKRGRRLAECLLEKLRLAAETDQNGHLNPLTQRLSRLIKTFSLTHPSSFILPRFWAKYENVLSSCLDMNIPDDRASFERLRARNTRVCRLNNGRAKPARSPHQRLIQLLDSSSDVSTICTECLNISRDYNMLATKVIEWASTSFRYGPARTYTAVRIFRRWKKTGIDMDFHLLSFLMQDHQRSGVRLLDVYHVICELVRSQSFSVAKYLQWLMARGLVSNGSGFQQNHILGVIELLGHLPSGRLPSHIWNLRNTLLSRTGFSVALEGDIIQRIKASVRRRLPNVFPKLPADRDAEMTDDVNLASLSWTVRSEIGNWIRDQVASHVKDSLKSAMDPDFASEVKTSALTPQEFFEVRYILECLGDLSMLADVLKYASGSDSVTVLASAVDTLNYHLDSFTAIGATSDLFKSFTGAYARIGKTELSVQDLIASLLDVAIKLPAELPTVAILRRDQLQRDRKLAMAASSPVSDHIVDTLNTANPTFTEELDQLLASGNSMDEVTMARIFDSLRKRLQAGSINGKQCAHETARYFAQLRPFNAKFFDNLMIKWVISVLKSSPRPNLSAILPPLIGVGCVTLHSFYVLAKALLHSDAHRNTIPDLAELRFNMIRLLDGRLSNGNGSQDLVAYRFKIARQEYMRQFSGEALGLMQDLLAEVSEGGTDSPPKQFNSDLLNTTVTPLLCEIIVRHPATVGVGCADRLLEKFPACMNLTNQALGCLLVSQVQIGLVAAEETIESINDFSLPFCLMRLRLLFGFECDGDVKKRIYDAVFEAAKSNVHKGQSYWVDVVGTLHADAAKEIRQRAEEQLLSLVLSSNSLPTSPTSESNVPSGCNVSALVCLRIVEDLSFSVPETGIPSLGPMLVEKMNMILHKVTVLENSIMNSNTSQDNDQSSAIRQSHATQEYVITFWFSIILRLVSIHRSTFAPGTLSKSDLGDQTRLLISISCIALSKTLSPKIPPSQPHPFLSTVPLAPVTLPQESQPQHLLQGTNTSISTNLQTQALDVAATLLDSIPGDARHQCARFLRDRCPPFLHPQNDPRLLFLLGPLAADTQPSSSSSTSQSSQQQPVAPTPPQATPGTPATPATPTATVSVSVGAGAPSSSSQQFQSGNIYNTASFIPFDDPNSLVGKLRVQQRGRIVGPYPLRPWEMLEESAPVIGVNDTAVNLGLFGARRVRGDVM
Length1642
PositionKinase
OrganismEmmonsia crescens
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Emmonsia.
Aromaticity0.07
Grand average of hydropathy-0.241
Instability index50.29
Isoelectric point8.83
Molecular weight181633.02
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15476
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      86.89|      24|      89|     838|     871|       1
---------------------------------------------------------------------------
  840-  863 (40.54/22.84)	ASGS..DSVTVLASAVDTLNYHLDSF
  938-  955 (21.38/ 6.36)	........VDTLNTANPTFTEELDQL
  957-  979 (24.97/ 6.03)	ASGNsmDEVT.MARIFDSLRKRLQ..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     172.76|      55|     182|     304|     407|       3
---------------------------------------------------------------------------
  339-  407 (75.91/139.91)	LDQCLGKSIPICRAIWlakcvgaNELRAfkRKGTSAGVASGlETKWVRdwtiSVQQFIEGVIASFGDAS
  528-  582 (96.85/52.55)	LSSCLDMNIPDDRASF.......ERLRA..RNTRVCRLNNG.RAKPAR....SPHQRLIQLLDSSSDVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     262.04|      83|     181|    1272|    1364|       4
---------------------------------------------------------------------------
 1272- 1364 (124.52/109.06)	LSLVLSSNSLPTSPTSESNVPSGCNVSalvCLRIVEDlsfSVPetgiPSLGPMLVEKMNMILHKVTVLENSIMNSNTSQDNDQSS.AIRQSHAT
 1456- 1539 (137.51/93.73)	ISTNLQTQALDVAATLLDSIPGDARHQ...CARFLRD...RCP....PFLHPQNDPRLLFLLGPLAADTQPSSSSSTSQSSQQQPvAPTPPQAT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.76|      24|     182|    1416|    1445|       5
---------------------------------------------------------------------------
   10-   33 (48.38/19.67)	PPSRPAP.PSRRPSAPSVLYAAPDP
 1421- 1445 (43.38/20.82)	PPSQPHPfLSTVPLAPVTLPQESQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     197.08|      64|     143|      53|     130|      12
---------------------------------------------------------------------------
   53-  117 (87.64/71.75)	.............................DCGDM......ADVGRPAKRLrLD.........TGNeHPSPSLDhhhhNQYQQQQYQNQNQNQ......................PNPQHHG.SSTASEAPES
  118-  161 (31.77/25.72)	SMNPL.......................................................................................dlmsassteqavrppwsfrsdiPRSGAGG.PPEPSQWPQS
  163-  266 (77.68/46.91)	SLPPLpirpwkygpqerylasttkpkdgmECGEVktipyrIDIPSVAPRF.ADkkpadfapwTGS.HPEDVLS....EQTAKQGFYDRVQVS......................SNESASArSSLYSQLKHR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15476 with Med12 domain of Kingdom Fungi
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