<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15475

Description Polynucleotide kinase 3'-phosphatase
SequenceMHELLLFASVPAKQHDDLRQQLAGLTVMQPNHVLERHVLFKAYKKPDAMKSRPGGSQDVQPGELQKLNKMLGGVMYYLQAIGAVRPEDFGSKPASGTDATGAIDNAGNPTPAAHDGYSTAKQSWRLDFKDIPEAGARSAVTSRVVGSVEVPYGDIVATMDGWGFHYVSEYVVEGDMLVLDDTVLFLHRVLNFPPGQQGVGRPAESLPPLDQMVPLDSSGAYVLQSCITVGESGNPDLLKAASQRLLGLREHLRSVVKLEPADRLALDTRANLRFSQTFLRQVRIRMVNSRGTKRRGTEDDISPPPLKRKAEPTATSKAAVANFFTPASQKKPEQTTWRIIDNSCLIGKYTVDERKNAQDIRNGSKRRVVALDLDDTLIATKSGNKFARSPSDWKWWNGKVPDRLKELDAQGFLVVVISNQKMISLRKDQKGGRTESKSLSNFKQKVSAVMKALDIPLSVYAATESDKFRKPRTGMWMEILEDHDLDVEGALDLSGSVFVGDAAGRPNDHSCCDRDFATNIGIPFKTPEEFFFDQPPETIVRAFDPKTYIVTSSDEESQSPLTRLNDIELVIFCGSPSAGKSTFYWEYLQPMGYERVNQDILKTRQKCLKVAEEHLSAGKSVVVDNTNADTETRTHWILLAKSLDIPIRCVYFTTPPEVCKHNNVVRASNQVESLNPESRALLPGIAFGDFSRRFREPELSEGFRDITRVDFRFQGSDTAREAWGQYWI
Length728
PositionHead
OrganismPolytolypa hystricis UAMH7299
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Polytolypa.
Aromaticity0.08
Grand average of hydropathy-0.448
Instability index43.13
Isoelectric point7.21
Molecular weight81124.98
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
kinase activity	GO:0016301	IEA:UniProtKB-KW
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15475
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     213.72|      54|     188|     451|     505|       1
---------------------------------------------------------------------------
  370-  413 (41.18/22.06)	.ALDLDD.TLIATKSGNKFaRSPSDWKWWNgKVPDrlKELDAQGFL..............
  451-  505 (88.78/61.10)	KALDIPL.SVYAATESDKF.RKPRTGMWME.ILED..HDLDVEGALDLSGSVFvGDAAGR
  641-  693 (83.75/53.18)	KSLDIPIrCVYFTTPPEVC.KHNNVVRASN.QVE....SLNPESRALLPGIAF.GDFSRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.74|      14|      43|      45|      58|       2
---------------------------------------------------------------------------
   45-   58 (26.02/11.87)	KPDAMKSRPGGSQD
   85-   98 (25.72/11.65)	RPEDFGSKPASGTD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15475 with Med18 domain of Kingdom Fungi
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