<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15473

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMEDLKSVKNSTAQWRTLLRRCLSQRTDASEFSGFVKLMLNRYFIPAKRLIDIILVSRSVTNVPWDPLIPLYVDTLHRLGCVKTENILESLLAHSTVSQKRVPAQNGSATTTPVSTLMTDYCIIHNATIAATSGHAPKTIADAANTFAALAKWILTLLSWNSTHRPESDPAGSLTNSPDTLAVFESLGILFAALVGTEKSVNALSASRSKAWRNKLGQALAEYIPLCAGVSIPLRDRLEVLRKDFNLYGHDGEKSLEDTMMENVNISALQFESHVLDGSIINSRAGPYIYVNALLFGRPLVDDSMVVNYLNNRYGGDRMTLIEDLITAAFDVLSNGMYRNESNRTMFIFRSFLVNKLPPFFAEMCASSIDPIPMELCITRALSRIDPNAFPSFSEMFTMQGNSILSDVRQEFLFACALHKLIPEASIERLLGENPMQTLPVGGQLRREDLVSQINNNPERAEQLINELESMEGNAGAIARAITEVMHSLCSRKETMTLKNICNSLSRRPLSLDVMLLFISPSTILQPLCALLDAWKWGEEQGESQPVYDEFGSILLLVLAFKHKYVLSHHDLGISNSDSFVLRLLQHGSSSQRLEDLDEKQKNNLGAWIAALFIAEGISDESMSSCSPQEFYFLVATLFSQSLAACETGKLEFETLKGGFELMALTWLGHHIWESESDLTTALKVLLALVKPSSISGEAQEIHRTVLLITAKSLEDQLKGVRTRHPSRNDIKPILEALEPYHSFQRRSTARYGEVESWAANPAGGGIVASIRNTFSSFVFWSTSPEISMTPPSYTHRQIVAGIRLVGAVRVLRGIIDELKLQAETGSGDLALDIAATLICAPLAESFAVDRAAFHPIDPSKDAVPRCPILTLRDALNLERDSIPKLMNSDTLRAELIVRLNRRVDALTAVPQMSQEVSNIDVSNIMQDINLEEGGMGMSSQGHNQGGETSNQVDQGADNTGDLNEMLDAAVAAAAGGDGAGNGQEMGMSGMGGIGMGMGNGMDTSIDDVLNGADMGVGNPEFLDLDMEGMF
Length1030
PositionTail
OrganismEmmonsia crescens
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Emmonsia.
Aromaticity0.06
Grand average of hydropathy-0.055
Instability index42.17
Isoelectric point5.08
Molecular weight112786.40
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15473
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     141.40|      34|      55|     933|     967|       1
---------------------------------------------------------------------------
  915-  933 (18.23/ 6.30)	.............EVS.N.IDV.SN.IMQDIN.LEEG
  934-  968 (58.88/44.25)	GMGMSSqGHNQGGETS.NQVDQGAD.NTGDLNEMLDA
  969-  985 (22.07/ 9.70)	AVAAAA................GGD.GAGNGQEM...
  992- 1023 (42.23/25.89)	GIGM...GMGNGMDTSiDDVLNGADmGVGN.PEFLD.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.64|      35|      61|     414|     449|       2
---------------------------------------------------------------------------
  414-  449 (55.80/37.65)	ACALHKLIPEAsIERLLGENPMQTLP.VGGQLRREDL
  474-  509 (54.84/32.62)	AGAIARAITEV.MHSLCSRKETMTLKnICNSLSRRPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     145.77|      45|     340|     255|     299|       7
---------------------------------------------------------------------------
  255-  299 (75.97/42.79)	LEDTMMENVN..ISALQFESHVLDGSIINSRAGPYIYVNALLFGRPL
  596-  642 (69.80/38.79)	LDEKQKNNLGawIAALFIAEGISDESMSSCSPQEFYFLVATLFSQSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.92|      28|     813|      45|      98|      10
---------------------------------------------------------------------------
   71-   98 (48.01/65.33)	YVDTLHRLGCVKTENILESLLAHSTVSQ
  564-  591 (48.92/18.47)	YVLSHHDLGISNSDSFVLRLLQHGSSSQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15473 with Med5 domain of Kingdom Fungi
Unable to open file!