<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15472

Description Uncharacterized protein
SequenceMTPHSSTAIPQLPLPRAVPSRTSGRPSASQPDPTLTSHVPHNAVVIDLSDNNYGTSGGDRPAKRLKLDAGVDMLDPGRMSAGVDLQPSINPSDLRRQFPSDASGGRQTWSTREGTIRTGQGGSMQDGNSEGEAQWSRPASLPPFPIRPWKYKPPKRHTAGVTHSKPIISADAVKTTPFRFQTPSDAPRVIAEKHADFYPWVGSHPEDVLTEQTSKQGFYDRVQVSQNESNTARPSLFAQFKHRAGLKLLSAVFTTALEKRQASSQVTASSTFRPPPRVTLTDNKREAWLRDLANASVPLRRLSRTIPHGIRGKVLLDQCLSKSIPIGRAIWLAKCVGANEIRAFKRKGTSAAVASGLEAKWVKDWTMNVQQFVEGVLGNCGEPDWKAKMSYALRLAARLFGEHLLDQDVFLEWFLTSLDTSSLNTLPAWLLMAGVYWESLVRYRKRGRRLAETLLEKLRQAQSFNHNNILHPITSRLSVLIKRFVQTRPSCFVLPQTWSKYQPVLFSCLNPGDQEEQLILAKLSDRNERVQRSKDVEKTAQKSPTQCLIRLLDSFCSSNDFSALSSECLKLPIDQSALIGKIMEWASTSFRAGLCRTYVAVRLLRRWKRCGVDIDSDILSFLAENHRGKGLRKMDIFHVISELIRSQSFSVGRYLQWLMARGVVHSKVLVGQTNGSTDVELLCHIPLCRLPEHVWNLRNTLLARTGYSVSGETRHTQLIKSFLKRRLPEIFSEDGGSEDHDMTDDINFATLSWTVKSHIGQWLRDHVASHIKSCLKSAMDNDFACDIKISRLTPDEFFEIRHVLECLSDLSMLADVLKHASRSDDAIVLASAADTLNYHFDSFNAIGATRDLFKSFTEAYVRVSKTDPPNTDLITSLLDVVIKVPDEIATLAVLRRDLVQLDRKLGIAASSPVSDHMADGLNTANPTFTEELNQLLASGNTMDEQTMARIFETLSKRLGSERTDLKLGTNEIARYLAQLRTFNTKTFDSLMVKWMVHFLKSAPRPSLVLILPPLIGVGCVTFQAFSSLVKAVVSSGSQREMIPDRLRLYLDMLRLLDTKEAADGPFLDLVLYRFKIARREYLSQCPFDVLSLVQDILVELSGSTATLAESDHGYALKDLILPLLREQIVSHQDIDSRDGVDKVLTKYPTCADVIHQALFSLLGLQAEGALAVVDDTMQLINDLSLPLCLAQLRLHFNTVSDDETKTKVLDLLFKTAESGVQSGNSHWRDVLGVLQADAAQHVRRRAESQILSMLLPPALQHSAADESSETTNPSRTSLVYLRIVEDLAYSIADGGASGFGASLVEKMNMLLQRVVLLSNETKNSDNPGVNGDAASGLAPAPQEQAIALWFYVLLRIVAIHHSTLSSTATSKSDLVDRTRLLITICCIALSPIFSKTQRFRFPSTIPLPPSKFQLDRSITAANLQVQALDVAATLVDSLPDEARQQCVRFLRERCPPFLQPQNDPRLLFLLGPLTDTPPPSSTPSQLPAPQNSQIAAGAANLAAPLPSHSFPASNSNNMTPTAAEDSNSLMSKLRFQQRGRIIGPYPMRAWEMLEESAPIVGVNDTALNLGYFGARQTRG
Length1579
PositionKinase
OrganismPolytolypa hystricis UAMH7299
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Polytolypa.
Aromaticity0.07
Grand average of hydropathy-0.211
Instability index43.59
Isoelectric point8.75
Molecular weight175046.06
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15472
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.19|      14|      16|     304|     319|       1
---------------------------------------------------------------------------
  304-  319 (18.86/24.10)	RTIPHGiRGkVLLDQC
  322-  335 (27.33/20.30)	KSIPIG.RA.IWLAKC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.82|      15|      17|    1487|    1501|       2
---------------------------------------------------------------------------
 1487- 1501 (25.96/17.30)	PAPQNSQIAAGAANL
 1504- 1518 (28.86/20.28)	PLPSHSFPASNSNNM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.42|      13|      17|    1229|    1241|       3
---------------------------------------------------------------------------
 1229- 1241 (21.90/12.70)	DVLGVLQADAAQH
 1249- 1261 (23.52/14.23)	QILSMLLPPALQH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     292.76|      98|     473|     416|     762|       4
---------------------------------------------------------------------------
   16-  118 (156.83/38.03)	RAVPSRTSG..RPSA.SQPDPTLTSHV.PHNA....VVIDLSDNN...YGTSGGDRPAKRLKLDAGVDMLDpgRMSAGVDLQpSINPSDLRrqFPSDASG..GR.QTW...STREGTIRT
  483-  597 (135.93/377.63)	RFVQTRPSCfvLPQTwSKYQPVLFSCLnPGDQeeqlILAKLSDRNervQRSKDVEKTAQKSPTQCLIRLLD..SFCSSNDFS.ALSSECLK..LPIDQSAliGKiMEWastSFRAGLCRT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.70|      14|      16|     814|     827|       5
---------------------------------------------------------------------------
  814-  827 (23.67/16.67)	ADVLKHASRSDDAI
  833-  846 (26.03/19.20)	ADTLNYHFDSFNAI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.88|      13|      18|     189|     201|       6
---------------------------------------------------------------------------
  189-  201 (25.41/16.84)	VIAEK..HADFYPWV
  208-  222 (18.47/10.22)	VLTEQtsKQGFYDRV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.30|      32|      71|     951|     985|       7
---------------------------------------------------------------------------
  951-  985 (48.82/37.79)	FETLSKRL...GSERtdlKLGTNEIARYLAQLRTFNTK
 1025- 1059 (49.48/30.33)	FSSLVKAVvssGSQR...EMIPDRLRLYLDMLRLLDTK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     165.80|      52|     398|     350|     406|       8
---------------------------------------------------------------------------
  350-  406 (76.42/64.41)	SAAVASGLeAKWVKDwtmNVQQFVEGVLGNCGEPDWKAKMSYAlRLAARLFGE..HLLD
  752-  805 (89.38/55.95)	SWTVKSHI.GQWLRD...HVASHIKSCLKSAMDNDFACDIKIS.RLTPDEFFEirHVLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.66|      17|     458|     998|    1014|       9
---------------------------------------------------------------------------
  998- 1014 (30.59/15.06)	FLKSAPRPSLVLILPPL
 1457- 1473 (32.07/16.15)	FLQPQNDPRLLFLLGPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     271.92|      70|     458|     680|     750|      14
---------------------------------------------------------------------------
  681-  750 (119.06/79.83)	LLCHIPLCR..LPEHVWNL.RNTLLARTGYSVS.GETRHTQLIKSF.LKRRLPEI...FSEDGGSEDHDMTDDINFAT
 1082- 1141 (66.02/39.63)	......LSQ..CPFDVLSLvQDILVELSGSTATlAESDHGYALKDL.I...LPLL...REQIVSHQDIDSRDGVD...
 1143- 1215 (86.85/51.92)	VLTKYPTCAdvIHQALFSL.L.GLQAEGALAVV.DDT..MQLINDLsLPLCLAQLrlhFNTVSDDETKTKVLDLLFKT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.33|      15|      16|     617|     631|      16
---------------------------------------------------------------------------
  617-  631 (25.17/14.09)	DILSFLAENHRGKGL
  635-  649 (25.16/14.08)	DIFHVISELIRSQSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.15|      10|     400|     473|     482|      17
---------------------------------------------------------------------------
  473-  482 (17.09/10.46)	ITSRLSVLIK
  874-  883 (17.06/10.42)	ITSLLDVVIK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15472 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MTPHSSTAIPQLPLPRAVPSRTSGRPSASQPDPTLTSHVPHNAVVIDLSDNNYGTSGGDRPAKRLKLDAGVDMLDPGRMSAGVDLQPSINPSDLRRQFPSDASGGRQTWSTREGTIRTGQGGSMQDGNSEGEAQWSRPASLPPFPIRPWKYKPPKRHTAGVTHSKPII
1
168










Molecular Recognition Features






MoRF SequenceStartStop




1) PIRPWKYKPPKRHTA
145
159