<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15469

Description CMGC/CDK/CDK8 protein kinase
SequenceMSLSNPPASAGGGPLTDAASARSAHASRPPAAAPGSNAAANMTNAAAHNANTHHPAHHQNLSLKRSVQAAFDDTFEPKRSPGCGYTCKVHIRDKYHIVGFISSGTYGRVYKAVGKNGQKGDFAIKKFKPDKEGEMIQYTGLSQSAIREIALCSELSHANVVQLVEIILEDKCIFMVFEYTEHDLLQIIHHHTQPQRHAIPAPMVKSILFQLLNGLLYLHSNWVLHRDLKPANILVTSSGAVRIGDLGLARLFYKPLNSLFSGDKVVVTIWYRAPELLLGSRHYTPAIDLWAVGCIFAELLSLRPIFKGEEAKMDSKKTVPFQRNQMLKIMEILGMPRKDDWPGLTSMPEYPQLQSLALSRGGSAQISKQPSLEAWYHTCLKSAGYASSPTPSGTPGKEGFDLLSRLLEYDPAKRLTAKEALEHPYFTTGSPVTANCFEGLEGKYPNRRVSQDDNDIRTSSLPGTKKSGLPDDSLVGRVAKRHKEM
Length485
PositionKinase
OrganismPolytolypa hystricis UAMH7299
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Polytolypa.
Aromaticity0.08
Grand average of hydropathy-0.332
Instability index45.29
Isoelectric point9.15
Molecular weight53286.35
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15469
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.06|      18|      22|       4|      25|       1
---------------------------------------------------------------------------
    4-   25 (30.47/24.76)	SNPPASAGGG....PLTDAAsarsAH
   27-   48 (30.59/15.72)	SRPPAAAPGSnaaaNMTNAA....AH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     188.37|      58|      85|     279|     336|       2
---------------------------------------------------------------------------
  279-  336 (101.44/56.88)	GSRHYT..PAIDLWAVGCIFAELLSLRPIFKGEEAK..MD.SKKTVPFQRNQMLKIMEILGMP
  362-  424 (86.93/47.84)	GSAQISkqPSLEAWYHTCLKSAGYASSPTPSGTPGKegFDlLSRLLEYDPAKRLTAKEALEHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.27|      11|      21|     244|     254|       4
---------------------------------------------------------------------------
  244-  254 (19.00/10.72)	GDLGLARLFYK
  262-  272 (20.27/11.81)	GDKVVVTIWYR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15469 with CDK8 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FEGLEGKYPNRRVSQDDNDIRTSSLPGTKKSGLPDDSLVGRVAKRHKEM
2) MSLSNPPASAGGGPLTDAASARSAHASRPPAAAPGSNAAANMTNAAAHNANTHHPAHHQNLSL
437
1
485
63










Molecular Recognition Features






MoRF SequenceStartStop




NANANA