<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15464

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGIIMDGTSSIGQGRDIDRQHVEGALSKSSLPPHNNSNYSNGSSHAKNATEPSDTSLDGSLPPELVHISQGFFPLGQLINRAAQQCWNDLTDLIAELAEPQATGSNAASHASPMATANGKYTSGQSADMVQKKTRILEFAQAKRADLIKILVLSQWSRRAADVSRLIDIQAFIRMRYDCYNGAILSIGEMKRDLIRAQTANPDLAMALEVLSTGKVAAMQERSFVPPKPLTPKAMLKTLKKINKAIRTRLVLHDEIPNAFTNYSVHDGRVTFEVPTEFEVDLSIAQEDRSSQFFFVDIRFLFSPSPPKPSGRLLDELDSRVNASLMRSGLTGCYNLLHNLVLSNKITVLFHQAIELARGHWLDNLRVEVLHRTLVVQYWINRPGPKSWIEIGIKSGRRKDEISQHGSIPGSPLLGLRWMRDGKEVDSKAVKFDLELLSMEAILRSVTALHISYLLQSTYSRLLQGRLYATAALTIGLQTSTTEPGNCFLDAQLTKGRELRVIIEPVSGAIIFRPTPLLLNRHDIDRSAERPTIDDILLRISRLRSAAVVEEVESLADAVGWETVNSRDIRAEDLRRIFPANILRSVLFFRRFWECNWGVAYTCSMDGDNWWVVELRPTQRLDAPSSRKGPVAPQYARMVTGRFGGLPGRLNYGSFGQLDHALSGMLAINANARYLSELHGIHHFPPTHKLALGTYLQVPSVFIRFRSSSLPPALQVSPLVTTSKTSAIKDTVRLSFKGIDASSQCAILIAHGHLSREIKDIAFLTGHSDSTITFQPKGRAFAMRFLTPVGRPMIIQLLARLQQLERIIDVLETLSQSRLKPLTVTLSHVRFAYAANEDARASINFNYHEHALTSDIDTITLLSKQTPLMHLRTSIDFHPQNPHRRIKESLTATLNGSHSGAAPGLETVLRLLVITLPVLKALDHICIDPATGRPGNSRLQVTARSSKVFHLRYPSIRYRFCIQITLRRDRVIWALKDMTVASEKVGQEALEQKLVESIYTTRGDGWQGLDNGAIANAEGVEGLLSTLHAVVTDYISSEAAAGRLNRGNAAGGAGAVAGGNAGAGSDGRKPPSQNPAAAKKDADNKPKSKPSQPGMGAGPGACRAGGLAPPKGTTAAAAVTKLGNDGSIPLNPEAIMMKQKQKAAKGGAQQGKNGKGNNNGARPAGPGPAGGNGNGNGGGNAGGAGGGNGNGKGKDVDFIMID
Length1203
PositionTail
OrganismHelicocarpus griseus UAMH5409
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Helicocarpus.
Aromaticity0.06
Grand average of hydropathy-0.241
Instability index40.21
Isoelectric point9.60
Molecular weight130653.69
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP15464
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      78.24|      15|      29|    1147|    1161|       1
---------------------------------------------------------------------------
 1053- 1068 (19.75/ 6.53)	GaGAVAGGNAGAGSDG
 1147- 1161 (28.34/12.85)	G.GAQQGKNGKGNNNG
 1178- 1192 (30.15/14.19)	G.GGNAGGAGGGNGNG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.77|      22|      47|     299|     323|       3
---------------------------------------------------------------------------
  297-  318 (39.99/23.89)	VD.......................IRFLFSPSPPKPSGRLLDEL
  322-  366 (22.78/17.99)	VNaslmrsgltgcynllhnlvlsnkITVLFHQAIELARGHWLDNL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.37|      13|      47|     137|     150|       4
---------------------------------------------------------------------------
  137-  150 (17.61/15.14)	ILEFAQAKRaDLIK
  185-  197 (22.76/14.70)	ILSIGEMKR.DLIR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.96|       8|      66|    1098|    1107|       7
---------------------------------------------------------------------------
 1098- 1107 (13.04/11.03)	AGPGAcrAGG
 1165- 1172 (18.92/ 7.80)	AGPGP..AGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      97.05|      32|      66|     796|     827|       8
---------------------------------------------------------------------------
  796-  821 (33.11/20.83)	......................................IQLLAR...LQQLERI.ID.VLETLSQSRLK
  822-  888 (33.27/20.97)	PLTVTLshvrfayaanedarasinfnyhehaltsdidtITLLSKqtpLMHLRTS.ID.FHPQNPHRRIK
  890-  941 (30.67/18.67)	SLTATL.............ngshsgaapgletvlrllvIT.LPV...LKALDHIcIDpATGRPGNSRLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     158.73|      50|      78|     655|     706|      10
---------------------------------------------------------------------------
  655-  706 (78.73/63.09)	SFGQLDhALSGMLAINANARYLSELHGIhHFPPTHKLALGTYLQVPSVF.IRF
  736-  786 (80.00/53.47)	SFKGID.ASSQCAILIAHGHLSREIKDI.AFLTGHSDSTITFQPKGRAFaMRF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15464 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GIIMDGTSSIGQGRDIDRQHVEGALSKSSLPPHNNSNYSNGSSHAKNATEPSDTSLDGSL
2) RGNAAGGAGAVAGGNAGAGSDGRKPPSQNPAAAKKDADNKPKSKPSQPGMGAGPGACRAGGLAPPKGTTAAAAVTKLGNDGSIPLNPEAIMMKQKQKAAKGGAQQGKNGKGNNNGARPAGPGPAGGNGNGNGGGNAGGAGGGNGNGKGKDVDFIM
3
1047
62
1201










Molecular Recognition Features






MoRF SequenceStartStop




1) AIMMKQKQKAAKGGAQQ
2) ARPAGPGPAGGN
3) GGNAGGAGGGNGNGKGKDVDFIMID
1135
1162
1179
1151
1173
1203