<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15460

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSHVPSSSSFQAGTPPSPSSPPADSAKTHQLHQQHRAKDQTPHTPTSPPLMSVGAQNYASSFSTTQTSPAQTLHSAPLSSPPSSVAMSTQVSQQPTVTSTTSFPTPASSVGGHFTGNNTMDEPEGTAKNVSADSRKDGGSFTSKESGSDFMDVDVSGHRRTDHDRQKGGFRGNLDENAMDLDYRAASSTQEEQLSLSALQQDIGTAFHLCKSSYTTSGPNPSLDLVSLYGLGPVAASVARTDPVTGEKINRLRKSYEGKIKGLCLAGRNKPVKAEPGAPGGLKYLTLWPEEEWQNQKVYGKEIKVAEPESSFLKQQLKAMKLEPGTLPNHEFWEDALGHEKPSKVAPGTGTDAKTVGTLPGQVRRPNQANGAYPSVSTPVAENTRPKRTGKKRSYNDSSFVGYGEGFPDDDGDIDSGIYSNSEEGGRGQGKKKRKKDHISGVSPTLTERGGSYGVGMFGVGAR
Length463
PositionHead
OrganismHelicocarpus griseus UAMH5409
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Helicocarpus.
Aromaticity0.06
Grand average of hydropathy-0.817
Instability index46.97
Isoelectric point8.28
Molecular weight49209.58
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15460
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     138.80|      26|      26|      65|      90|       1
---------------------------------------------------------------------------
   14-   30 (26.24/10.46)	..TPP........SP.SSPPADS.....A...KTHQ
   32-   63 (33.58/15.75)	HQQHRAkdQTPHT.PTSPPLMSVgaqnyA...SSFS
   65-   90 (47.43/25.71)	TQTSPA..QTLHSAPLSSPPSSV.....A...MSTQ
   92-  118 (31.55/14.28)	SQQPTV..TSTTSFP..TPASSV.....GghfTGNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      87.40|      19|      21|     308|     326|       2
---------------------------------------------------------------------------
  289-  307 (27.57/12.25)	PEEEWQNQKV...YGKEIKVAE
  308-  326 (31.16/14.59)	PESSFLKQQL...KAMKLEPGT
  328-  349 (28.66/12.96)	PNHEFWEDALgheKPSKVAPGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     149.58|      38|      39|     382|     419|       3
---------------------------------------------------------------------------
  361-  386 (37.87/15.37)	...GQVRRPNQAN....G.AYP....SVSTPVAENTRP
  387-  424 (64.81/30.77)	KRTGKKRSYNDSSFVGYGEGFPDDDGDIDSGIYSNSEE
  427-  458 (46.89/20.53)	RGQGKKKRKKD.HISGVSPTLTERGGSYGVGMF.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.22|      18|      27|     135|     161|       4
---------------------------------------------------------------------------
  135-  154 (24.03/33.12)	RKDGGsFTSKESgSDFMDVD
  165-  182 (33.19/13.96)	RQKGG.FRGNLD.ENAMDLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      86.51|      24|      39|     211|     236|       5
---------------------------------------------------------------------------
  188-  208 (19.31/ 7.08)	......STQEEQLSLSALqQDIG.TAFH
  211-  236 (36.50/27.15)	KSSYttSGPNPSLDLVSL.YGLG.PVAA
  253-  274 (30.70/16.43)	RKSY..EGKIKGL...CL.AGRNkPVKA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15460 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DGDIDSGIYSNSEEGGRGQGKKKRKKDHISGVSPTLTERGGSYGVGMFG
2) MSHVPSSSSFQAGTPPSPSSPPADSAKTHQLHQQHRAKDQTPHTPTSPPLMSVGAQNYASSFSTTQTSPAQTLHSAPLSSPPSSVAMSTQVSQQPTVTSTTSFPTPASSVGGHFTGNNTMDEPEGTAKNVSADSRKDGGSFTSKESGSDFMDVDVSGHRRTDHDRQKGGFRGNLDENAMDLDYRAASSTQEEQLSLSA
3) PNHEFWEDALGHEKPSKVAPGTGTDAKTVGTLPGQVRRPNQANGAYPSVSTPVAENTRPKRTGKKRSYNDSSFVGYGEGF
411
1
328
459
198
407










Molecular Recognition Features






MoRF SequenceStartStop




1) KKKRKKDHIS
431
440