<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15457

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPAGALTNFYAIDGFFHIFWRIYSRAAPESPASQLNSPGKPALRDTDELRNSLLVLRNIGCLVSPVANGADLWIFSTDPNFDALGPVSSNKGGEKEVIVVGNATLQSSVSGVNTAAEIKQRLLSDPGSSILNSTAPQNSLAPNSGAHTRFQDVATYSSLFEAFISAAARALILEFTQQQKVIPLGTRTLYSVLDDNGYQNGSLDPPRSRKLTSFLSTLEMAMTSKGELVVSLSTLSQPGLEQLYAGVGSDISDTYFNNDLWLAPSGILCRLIAIDRGRSHKSDIVSPGQVGILPTEFEIPPISNITRLEWKITVTEWLRKLGLNINDPEKELWVEVEVHASERPFHGAYSGSYGDQKASSPSIQILWPAKLCFVRSHSDGTMSVNPTEFFSSKAESPLQFVDRWLSEPFPKAQPFDKHKTSGDASELKKQQTKLSEPSPLKIDSSNMPESLARTVTMPDAQLASTVYPTPPGGLLAPSLGVGGVPEGHGTSTLDALSYPPTQNETIYNEPSGSTTLFRPNSDVLPAGLDAASSDLGVGSGLYDTVADEDFFGDMDGTNFDTKDITEADFNFFDEPEFAGLAGDFGTQNGPPEQHQEPTEPTPTIPATSHTMSKTEQGPSSNVHTTGNGFKSAKNLMVNPSTTSATQGLVSTETPGLDRAAPIDRPEEPPISPPLSPVQIKKILSPSVSAVPISQFFKPDVDRSSRSQNQYSAVTFQPKVWSSDKKYKMDGRFWFTPEREHIAPKLGTYPSDIPMIGFPDRGRKPRPKPVSTQTSPSALASDNFPESELRSPSTSSSTSADDGSITDIGSESSSPPVTCARPKRKRNYGDGDDSASSSLERHPLVSDVSNGDLNEHQLALLGIFVSDAVDWPLTGYFSKKQNDIFPAFSRREDMPQVVQLVVDQITQTSLHHTRDDLHRLEGADWDGMLSRSLFSDNDCLGHMSKLDLRTYATLEDVPNPRKDTPQVKPNAPGSICKIFSPHVKVHRGDRYLEVLPTAIGFWETFGLEPVQKEKNIIPFCIYPPNIAEAADAFMERMGLVYSVGNFGSHSRPSRSNGLVPWTLNAASDQDYTSLMHALNVTCEDLGSALSNLPASNENVVVYIVNPFVYDASLVDICSAFLRLFHKYVGDVDRQHTRNLNELVLQIVPLDFVASADSLVVPTQFDFLRLALEVYSRCPPKDRSSDWLGCAPPLVLADPVPKVVPFRLASESVAPLEEGKCLHVAYSQSVDQRWVTAAWTDNSGRYQTTLSYCLRERDSPVSRTISEIRAQIWETTQDIMDMSSSHWKLMIVKNEPVGAEEIEMWKSHLDHYNRNKAIKVELVILSVNIKPGLSLKLPSPPLQLSSLSQQQAHTAASMTTPGSTPRPVPSPDPSGPVGTPTAPSFTDHHPQSQPPQQHPPQPPVDSDQDTFLIDKSDETWGVTLSHRLNNSYSLTKYQPALASGYLFRRSGTSDTEGQAALSVNIIFTNSRRPIDHLLKDILRMYRELATLARARGIVHAQGNFSLPWHIMTAAKGQEVLSYTL
Length1524
PositionKinase
OrganismHelicocarpus griseus UAMH5409
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Helicocarpus.
Aromaticity0.08
Grand average of hydropathy-0.377
Instability index50.51
Isoelectric point5.33
Molecular weight166831.08
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15457
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     712.69|     264|     366|     138|     503|       1
---------------------------------------------------------------------------
  185-  344 (154.29/150.53)	.....................................................................................................................................................................................PLGTRTLYSVLDDNGY.........QNGSL..DPPRSRKLTSFL...STLEMAMTSKGELVVSLS.TLSQPGLEQLYA.........GVGSDISDTYFNNDLWLAPSGILCRL..................IAIDRGRSHksdivSPGQVGILPTE..FEIPPISN.ITRLEwkitvtewlrklglniNDPEKElwveveVHASE
  345-  628 (337.35/212.22)	RPFHGaysgsygdqkAS....SPSIQilwPAKLCFVRSHSDG...TMSVN.PTEFFSSKAESPLQfVDRWLSePFPKAQPFDK.HKTSGDASELKKQQTKLSEPSPLKIDS.SNMPESLARTVTMPdaqlASTVYP.......TP.PGGLLAPSLGV.............GGVPEGHGTST................ldalsypptQNETIynEPSGS...........................T.TLFRPNSDVLPAgldaassdlGVGSGLYDTVADEDFFGDMDGTNFDTkditeadfnffdepefagLAGDFGTQN.....GPPEQHQEPTEptPTIPATSHtMSKTE................QGPSSN......VHTTG
  629-  773 (104.55/29.35)	NGFKS..........AKnlmvNPSTT...SATQGLVSTETPGldrAAPIDrPEEPPISPPLSPVQ.IKKILS.PSVSAVPISQfFKPDVDRSSRSQNQYSAVTFQP.KVWS.SDKK..................YKmdgrfwfTP.EREHIAPKLGTypsdipmigfpdrGRKPRPKPVST.............................................................................................................................................................................................................
 1336- 1455 (116.51/44.06)	...................................................................................................KLPSP.PLQLSSlSQQQAHTAASMTTP....GSTPRP.......VPsPD....PS.G.........................PVGTPTAPSFTDHHPQ.....sqppQQHPP..QPPVDSDQDTFLidkSDETWGVTLSHRLNNSYSlTKYQPALASGYL.........FRRSGTSDT.............................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.75|      39|     778|      32|      74|       2
---------------------------------------------------------------------------
   32-   74 (54.78/38.83)	SPASQLNSPG.KPALRDTDELRNSLLvLRNIgcLVSPVANGaDL
  815-  854 (67.97/33.59)	SPPVTCARPKrKRNYGDGDDSASSSL.ERHP..LVSDVSNG.DL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.07|      18|      21|     904|     921|       3
---------------------------------------------------------------------------
  904-  921 (31.38/18.78)	DQITQTSLHHTRDDLHRL
  927-  944 (31.69/19.04)	DGMLSRSLFSDNDCLGHM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15457 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KAQPFDKHKTSGDASELKKQQTKLSEPSPLKIDSSNMPESLARTVTMPDAQLASTVYPT
2) PEFAGLAGDFGTQNGPPEQHQEPTEPTPTIPATSHTMSKTEQGPSSNVHTTGNGFKSAKNLMVNPSTTSATQGLVSTETPGLDRAAPIDRPEEPPISPPLSPVQIKKIL
3) PGGLLAPSLGVGGVPEGHGTSTLDALSYPPTQNETIYNEPSGSTTLFRPNSDVLPAGLDAASSDLGVGS
4) PKLGTYPSDIPMIGFPDRGRKPRPKPVSTQTSPSALASDNFPESELRSPSTSSSTSADDGSITDIGSESSSPPVTCARPKRKRNYGDGDDSASSSLERHPLVSDVSNG
5) PSPPLQLSSLSQQQAHTAASMTTPGSTPRPVPSPDPSGPVGTPTAPSFTDHHPQSQPPQQHPPQPPVDSDQDTFL
413
577
473
745
1338
471
685
541
852
1412










Molecular Recognition Features






MoRF SequenceStartStop




NANANA