<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15454

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPMMMEDAIDVDDLFVDPTLELGLANVASTVKGLAQRLDELRLLGCCQKVTWSKLGVIAYISQDGHKVLLRYLHCRPDDGQWALSDESVLDAVAETHGGRTLVHLCWNESGSDLAVVDSTGRISTFSSPIALNVFTISRPASEDAEDDGGGPVGLVWLNLNRPMHAFHKGTKANGRWAYVPYRRRPLGPLHPLNKSGLVSVTRSGHIRLLYQNPDSKWAQISIEIRSLGFSDDILTHAALWPTDGGFLMATHSSCARICLYRVQVKWDPAQWEPHKPGAPPNPFPTPSFHLYHMKTETPSGIFQPAGHAVDNLDDFLHSNTTPYSLTHLEIIAPSPDTPGGSPKPYILAIFSLPVNPSAGQSHNSSPPSVIVRWQLDIMKQTLHPSFDDVVSKKANVQLKPKSVLRRQDDINLDRSVVAIEHIDAGNILAISYEDGSIASFDADSMTSLNGVEDVNNVTSMAQAGFSFPLDTPGHYISFSPNSCLAAVLDGDGQLRLRYMGHSFGAEDGLYDDGKFSSAMAALALAYARACCNESASDDVLALVMQQLTPDIQKSFINEVYRALPVNVDFTVEQDKLMNNQYIQKCLSMQSALGFKSRIQQRSLAAVVPWVTLNLRQISILFAYFFHFNKSGREAEAQEPEILRMIHGNVKWALDLAKYLVDDLFEMADNLQNLPTDPNSFSQSARNFESLSVMLILSSVPRSFLKYICRGIRGLVFGFKGAANLSAESFRIYSSIYNLIEESPLKVDVYEKLLANVDSAVKHAYQGAGFGGGDRAAPERELIITSNIPPVLQSAVVTILTKTMPLFRSEVDRMALCLQDYTWLGLGDDKRTELFKRHNEVDILKRVVIGLDFPDRATQPKRRCVRCCEVSEDVALPKTISVLRMVAKVQVLRSCICGGMWAVENVDKLPSQVFPG
Length916
PositionTail
OrganismPolytolypa hystricis UAMH7299
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Polytolypa.
Aromaticity0.08
Grand average of hydropathy-0.109
Instability index49.09
Isoelectric point5.94
Molecular weight101221.46
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15454
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.24|      19|      20|     149|     168|       1
---------------------------------------------------------------------------
  149-  168 (32.50/19.94)	GGGPVGlVWLNL...NRPMHAFH
  170-  191 (28.75/13.24)	GTKANG.RWAYVpyrRRPLGPLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     340.92|     116|     426|      17|     139|       2
---------------------------------------------------------------------------
   17-  139 (184.71/149.50)	DPTLEL.GLANVaSTVKGLAQRLDELRLLGCCQKVTWSKLGVIAYI.SQDGhKVLLRYL.HC.RPDDGQWalSDESVLDAVAEthgGRTLVHLCWNESGSD..LAVV..DSTGRI.STFSSPI..ALNV...FTISR
  444-  574 (156.20/105.00)	DSMTSLnGVEDV.NNVTSMAQAGFSFPLDTPGHYISFSPNSCLAAVlDGDG.QLRLRYMgHSfGAEDGLY..DDGKFSSAMAA..lALAYARACCNESASDdvLALVmqQLTPDIqKSFINEVyrALPVnvdFTVEQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      98.55|      20|      21|     323|     342|       5
---------------------------------------------------------------------------
  283-  302 (35.22/20.08)	PFPTPSFHL.YHMKTETPSGI
  323-  342 (35.41/20.23)	PYSLTHLEI.IAPSPDTPGGS
  345-  365 (27.92/14.39)	PYILAIFSLpVNPSAGQSHNS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15454 with Med16 domain of Kingdom Fungi
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