Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MDTQLLTPLTSLETRLNNLLMSIISSPTAAGAPAAALALLEADDALSSALDTLHTHQANYVKILRLRAEALSLEERVRDIVREVESVGNEIDAACQRETGASEDSESSEEDSEGEEDTQMGGVGDGSSGRGKGSRRNEVDYKLLVNFARRISRYNSEAAADAGAGSPTKTPPGEEQSQLQQKGVNEGGANGEAVERAGSGVGANGQQAKGVGVAALSQETVSWLNETANWSRDISRMPFPSEERIRMGVMGQLLAASSEGLDVEKEIERMIHASQGGGGAGVPASENVTGMDEVVGVGEDMSASGRGHDHVGGGGVGRADVGVPAGRPKPKPVLDLDLYDPDEDE |
Length | 345 |
Position | Middle |
Organism | Helicocarpus griseus UAMH5409 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Helicocarpus. |
Aromaticity | 0.02 |
Grand average of hydropathy | -0.510 |
Instability index | 48.00 |
Isoelectric point | 4.51 |
Molecular weight | 35991.00 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP15453 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 5| 178.61| 36| 38| 155| 190| 1 --------------------------------------------------------------------------- 98- 123 (25.45/ 7.01) ..ETG..ASED......SESSEEDSEGEEDTQM..GGV......... 124- 150 (28.71/ 8.71) ..........G......DGSSGR.GKGSRRNEVDYKLL...VNFARR 155- 190 (58.27/24.14) NSEAA..ADAG......AGSPTKTPPGEEQSQLQQKGV...NEGGAN 192- 229 (29.22/ 8.98) ..EAVerAGSG......VGANGQQAKGVGVAALSQETVswlNET.AN 240- 280 (36.96/13.02) PSEER..IRMGvmgqllAASSEGLDVEKEIERMIHASQ...GGGGA. --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 56.86| 17| 38| 2| 18| 5 --------------------------------------------------------------------------- 2- 18 (28.20/20.58) DTQLLTPLTSLETRLNN 43- 59 (28.66/21.03) DDALSSALDTLHTHQAN --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) DYKLLVNFAR 2) VGVPAGRPKPKPVLDLDLYDPDEDE | 140 321 | 149 345 |
© 2021 Shailesh Lab
Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab