<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15450

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGIIMDDVRSGIGRAPLENGTQTYHDRMLDASLPENAETNSHLRKNGVNETAFSDYGNPSTAMPSTLAPLPPELVHISEGFFPFAQLINRAVQQCWNDLTELITELADVKLASVNGTSPSAQLNTAMNGKARSENAQKRLRLLEMLQMRRAEFIKLLVLSQWGRRATDVSKLIDLQAFIRMRYDMYNGATLYVGEMKRDLIRAQMGNPDLRTAFEVITTGRLGSMQHLGFISPGKLTSQKMLKTIRSIDKLIKSRLILHDSVPLAFANYTVRNGRVTFVVQAEFEIDLSIAHEDPRSQFFFVDLRFLFQPAPSVTDGRLFDELDHRVNTALMDRGLPGCFVLLHNLALTNKITILFKQAIQLARGQWINSLRVELLRRTLVVQYWANKPGPKSWVEIGINSGFRVQDSMIPNTSFLSLRWVRDNKEVDAQGINFDLQNLSMESLLRSVISLHISHTLRSAYAKLCETRLYGDGTLHIGLQMSSIEPADCCLEMQLTMGRRLKMTLESFTGAAVYQTVPLLLNRQDTEYNMDRSPLEEVTSRIYRLRSAAVMEEFDAHIKCLGWKTVNPRGVRTEDLRRAFPPRVIRFMVVRCVDWRRDWVAAQTSGPDGDNLWAIHLREIGDVAKHDGQPRYTGHFALQSVYMLTDRFPAAIQGSIRSSTARLEYSLSGMICILANARYLSALGLLQQVSGSGKLVLDDLLGVPSLSFRFRSRSLPVGLQIAPLPADGKAPCIKETILLSFKGIDPRSRYVTVIARGQLASPIKNISHLAAKMEPLVAFPPKSREFVMLFSAPAGEPIILPLLYRLQKLEHVLFMAQLLDPKDFRLQSISLSRLRFIYSTEEYSRGDIKFNYRKRTLKSDIECSELLSTTTPLSSLRMSIDFHPRNPQRLIKDSLTAALNGPTLGTSFSNVMALLTATLPLLRSLKDISTGELFKSRVLVTPRSAKVYYLRYPPYRNRFQIGLSHRRGRMVWILRDVPAASARVSQARETLGSDLRQNIYSSKGDGWVGLETGAIADAEKVGNLLLALDGIMKRHLVTLPSSGSAGHRMRPAGGTEIRPPRTTTNESQKDHFDPKAARVNSPGQERSTEKPSMGLRTTDIHRSNIPPKSPATNKKPEVIMID
Length1123
PositionTail
OrganismPolytolypa hystricis UAMH7299
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Polytolypa.
Aromaticity0.07
Grand average of hydropathy-0.214
Instability index48.35
Isoelectric point9.74
Molecular weight126092.21
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	ARBA:ARBA00003669
ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15450
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.00|      30|     210|     212|     257|       1
---------------------------------------------------------------------------
  223-  255 (41.81/58.13)	LGSMQHLGfiSPGKLTSQKMLkTIRSIDKLIKS
  684-  713 (48.19/28.27)	LGLLQQVS..GSGKLVLDDLL.GVPSLSFRFRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     606.12|     211|     396|     363|     625|       2
---------------------------------------------------------------------------
  363-  625 (305.02/351.33)	LARGQW......INSL..RVELL......RRTLVVQYWANKPGPkswveIGINSGFRVQDsmIPNTSFLSlrWVRDNKEVDAQGINFD.LQNL.SMESLLRSVISLHI.SHTLRSAYAklCeTRLYGDGTLHIGLQMS.SIEPADC......CLEMQLTmGRRLKmtlESFTG..AAVYQTVPLLlnrqdteynmdrspleevtsriYRLRSAAVMEEFDAHIkclgwkTVNPRGVRTEDLRraFPPRVIRFMV......VRCVdW.RRDWVAAQ...................TSGPDGdnlWaIHLrEIGDVA
  755- 1017 (301.10/216.77)	IARGQLaspiknISHLaaKMEPLvafppkSREFVMLFSAPAGEP.....IILPLLYRLQK..LEHVLFMA..QLLDPKDFRLQSISLSrLRFIySTEEYSRGDIKFNYrKRTLKSDIE..C.SELLSTTTPLSSLRMSiDFHPRNPqrlikdSLTAALN.GPTLG...TSFSNvmALLTATLPLL......................RSLKDISTGELFKSRV......LVTPRSAKVYYLR..YPPYRNRFQIglshrrGRMV.WiLRDVPAASarvsqaretlgsdlrqniySSKGDG...W.VGL.ETGAIA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.05|      16|     144|     154|     169|       4
---------------------------------------------------------------------------
  154-  169 (27.34/22.85)	FIKLLVLSQWGRRATD
  170-  185 (26.71/22.12)	VSKLIDLQAFIRMRYD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15450 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) TYHDRMLDASLPENAETNSHLRKNGVNETAFSDYGNPSTAMPS
2) VTLPSSGSAGHRMRPAGGTEIRPPRTTTNESQKDHFDPKAARVNSPGQERSTEKPSMGLRTTDIHRSNIPPKSPATNKKPEVIMID
24
1038
66
1123










Molecular Recognition Features






MoRF SequenceStartStop




NANANA