<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15446

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSHAPPPSSVHAGPPASPSSPAVDRAKPHQLYQPNHPKDQTPHTPTSPPLMSVSAQNYASSFSTTGTSPAQTFQPASLSSPPSSVAMSTQVSQQPTVTSTTSFPTPASSAGGHFTSNQTMDDAEGISKNGATDEQKDGELCTGKEVGLDVMDIDTSEHRRTDHDRQKCDIGTIPDGNTMDLDRAVSSTQEEKLNLKALRQDIGTAFHLCKSSYTASGPNPSLDLVSLYGLGPVASSVARTDPVTGEKINRLRKSYEGKIKGLGLAGRNKPVKAEPGATGGLKYLTLWPEEEWQNQKVYGKDIKVAEPDSSFFRQQLKAMKMEPGPLPNHEIWEDALGHEKTSKVMVANDASLAKAAGTVPGAIRQPVHTNGTPSMISTPTTEYTRPKRTGKKRSYNDSSFVGYGEGFPDDELDLDSGRYSNSEEGGRGPGKKKRKKDHISGVSPALTERSGSYGVGMFGVGAR
Length463
PositionHead
OrganismBlastomyces parvus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Blastomyces.
Aromaticity0.05
Grand average of hydropathy-0.762
Instability index44.83
Isoelectric point7.23
Molecular weight49392.23
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15446
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.34|      23|      23|      62|      84|       2
---------------------------------------------------------------------------
   62-   84 (42.23/21.48)	FSTTGTSPAQTFQPASLSSPPSS
   87-  109 (37.11/17.94)	MSTQVSQQPTVTSTTSFPTPASS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.06|      15|      30|       7|      21|       3
---------------------------------------------------------------------------
    7-   21 (30.04/14.42)	PSSVHAGPPASPSSP
   34-   48 (30.02/14.41)	PNHPKDQTPHTPTSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     163.49|      38|      88|     274|     311|       4
---------------------------------------------------------------------------
  274-  311 (67.63/34.23)	EPGATGGLKYLTLWP.....EEEWQNQKVYGKDIKVAEPDSSF
  314-  350 (33.92/14.19)	.....QQLKAMKMEPgplpnHEIWEDALGHEKTSKVMVANDA.
  365-  400 (61.94/30.85)	QPVHTNGTPSMISTP.....TTEYTRPKRTGK..KRSYNDSSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     149.29|      48|     223|     174|     231|       6
---------------------------------------------------------------------------
  174-  231 (66.67/60.22)	PDgNTMDLDRAVSSTQEEklnlkALRqdiGTAFHLCKSSYtASGPNPSLDLVS.LYGLG
  408-  456 (82.62/46.36)	PD.DELDLDSGRYSNSEE.....GGR...GPGKKKRKKDH.ISGVSPALTERSgSYGVG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15446 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ELDLDSGRYSNSEEGGRGPGKKKRKKDHISGVSPALTE
2) KAAGTVPGAIRQPVHTNGTPSMISTPTTEYTRPKRTGKKRSYNDSSFVG
3) MSHAPPPSSVHAGPPASPSSPAVDRAKPHQLYQPNHPKDQTPHTPTSPPLMSVSAQNYASSFSTTGTSPAQTFQPASLSSPPSSVAMSTQVSQQPTVTSTTSFPTPASSAGGHFTSNQTMDDAEGISKNGATDEQKDGELCTGKEVGLDVMDIDTSEHRRTDHDRQKCDIGTIPDGNTMDLDRAVSSTQEEKLN
411
354
1
448
402
194










Molecular Recognition Features






MoRF SequenceStartStop




1) KKKRKKDHIS
431
440