<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15442

Description Polynucleotide kinase 3'-phosphatase
SequenceMHELLVFASIPAKQHHDLLQQLSGLTAMQPTRTLERHLIFKAYRKPGFIKTRPGGSQDVQAPEVQRLNKLLNGGLYYTQVVGRVRERDFGSGPSSSSSGQDIAMQGSGDGGTTHPEASSSNKSNHDDGAATATTTTAGTGGAYVMANQTWRLEFKDTPDAGTRSAVTSRFVGSAKLGSGDVLPEMNAWGYNYVSEYVVEGHTFILDDTVLFLHRVLTFPSSPSSGGTATAEAPTPAENLPPLDKMVPLDMSGTYVLQASITVQDSGNPDMLKANSQRLLGLKEHLKSVVKLEPADRLSLDTRTHVRPSHLNKPLARYMMTGTKRSSPNGDISPPPLKRKALDPATSKSASNFFTPLSQKKPESVTWRVVDNSCIIAKYHPEEAAAAVKSGSKRRIAAFDLDSTLIATQSGKRFAANANDWKWWNSVVPGKVKELNDKGYLIVVLSNQKAISLKKEVKGGRVDSKSLSIFKQKVAAVMRSLDVPFSLYAATEYDQFRKPRMGMWREVVDDYDLDAEGMLDLEGSIFVGDAAGREGDHSCVDRDFAANVGIPFKTPEEFFLDEPPKLASRAFDPKTYILDTAEDEQKIAFAKKNDIELVIFCGSPGSGKSTYYWRYLKPLDYERVNQDILKSRPKCLKVAKEFLTAGKSVAVDNTNANPETRAHWVQLAKELNVPIRCINITTPPQICRHNDAVRANNTKIESINPESRTMLPGIAFGDFARRFREPTLSEGFQDIIQVEFKFQGPPAVKEVWGQYWV
Length756
PositionHead
OrganismHelicocarpus griseus UAMH5409
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Helicocarpus.
Aromaticity0.08
Grand average of hydropathy-0.443
Instability index35.93
Isoelectric point8.83
Molecular weight83353.45
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
kinase activity	GO:0016301	IEA:UniProtKB-KW
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15442
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     175.07|      43|      70|      73|     116|       1
---------------------------------------------------------------------------
   73-  116 (75.32/35.80)	GGLY.YTQVVGRVRERDF.GSG............PSSSSSGQDI..AMQGSGDgGTTHPE
  140-  184 (55.02/22.26)	GGAYvMANQTWRLEFKDTpDAG............TRSAVTSRFVgsAKLGSGD...VLPE
  189-  231 (44.72/17.08)	GYNY.VSEYV..VEGHTF.ILDdtvlflhrvltfPSSPSSG.............GTATAE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.79|      31|     187|     422|     552|       3
---------------------------------------------------------------------------
  339-  371 (50.02/80.34)	KALDPATSKSASNFFTPLsqKKPESVTWR.VVDN
  478-  509 (53.77/72.10)	RSLDVPFSLYAATEYDQF..RKPRMGMWReVVDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.94|      23|     355|     267|     314|       5
---------------------------------------------------------------------------
  243-  265 (37.05/37.79)	DKMVPLDMSGTYVLQASITVQDS
  286-  308 (37.89/18.98)	KSVVKLEPADRLSLDTRTHVRPS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15442 with Med18 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ERDFGSGPSSSSSGQDIAMQGSGDGGTTHPEASSSNKSNHDDGAATATTTTAG
2) SHLNKPLARYMMTGTKRSSPNGDISPPPLKRKALDPA
86
308
138
344










Molecular Recognition Features






MoRF SequenceStartStop




NANANA