<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15441
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MVEESFTLPLRPPTRRPSNPDSLATRIAQINAQRGSFRNVTEEGLQTEIDTLQAAGLTGDEEEEPESCDTKSPDRLEQLYKSRMEIIQFAAQAHAEATYALDFVSLLLSKHTPRQAEISMSPILKQKAPLGSLDVDVIKQPEQSESSKKDIDTVSRGWKLENFDCAANKILKSATRLEEEVAAETKYWAEVLSIKEKGWKISRLPRERQTLGVHFGLLEATPIFRDRGLAALRRANGGDLLLDQGLHVNRPRAMRVRVQENGHTVGSSPVKGLPSQPENLVESRIRHARDSLYEEELFHELNREARALLQHGIETKHNLVQFKASDTQQILIDLVDLNNPDLDVYEMSKSRAEDNLAESLATSLRILLSYAHRQNLRRRTQIPPPLKAGKRPTPEFPLLGPIVCFLQHRSEFQWMRSFLDDLRGTLKSAGLSFWYTASPASSINQSNPPSRSTPPPQPPSPIESLVSTFIGPMESFISGTFLSETSGFRLRISTHVAPNGYGTEFELFTNLPCMPGTNTTAPQRFGLRSELQDYMLYLFTIDLVYLIPPLSGNVNSPVAQTTHTHSHFRADTDDDEEDDIEDTASQPLFHLSSLSTITTYLAAWEPTFAKYGELTAYCPSRRRTKKLRVDLRRDRLVLRSGWVGGSECEGDEEGVDRVGRGGAGMVTDGKGAIAYVWRPGTGEEEEEEESKVKIDDGSEGEKSLQSVVLLMGAKDV |
Length | 716 |
Position | Head |
Organism | Polytolypa hystricis UAMH7299 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Eurotiomycetidae> Onygenales> Ajellomycetaceae> Polytolypa.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.524 |
Instability index | 59.40 |
Isoelectric point | 5.48 |
Molecular weight | 79991.04 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
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GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
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GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP15441
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 81.96| 23| 38| 642| 664| 1
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642- 664 (42.36/23.95) W.VGGSECEGDEEGVDRVGRGGAG
677- 700 (39.60/21.94) WrPGTGEEEEEEESKVKIDDGSEG
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 59.62| 16| 103| 501| 530| 2
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501- 516 (31.34/38.58) YGTEFELFTNLPCMPG
537- 552 (28.28/ 7.39) YLFTIDLVYLIPPLSG
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 262.80| 64| 373| 9| 75| 3
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9- 72 (109.40/67.36) PLR..PPTRRPSNPDSL.ATRIAQINA.QRGSFRNVTEEGLQTEIDTLQAAGLTGDEEEEPESCDTKS
385- 446 (106.62/65.34) PLK...AGKRPTPEFPL.LGPIVCFLQ.HRSEFQWM.RSFLDDLRGTLKSAGLSFWYTASPASSINQS
449- 494 (46.78/21.88) PSRstPPPQPPSPIESLvSTFIGPMESfISGTFLSET.SGFRLRIST.....................
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 75.86| 22| 24| 208| 229| 6
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208- 229 (37.75/22.18) RQTLGVHFGLLEATPIFRDRGL
233- 254 (38.11/22.46) RRANGGDLLLDQGLHVNRPRAM
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 56.06| 12| 38| 271| 282| 7
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271- 282 (19.48/10.69) KGLPSQPENLVE
299- 310 (17.61/ 8.97) HELNREARALLQ
311- 321 (18.97/10.23) HGIETK.HNLVQ
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