<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15441

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMVEESFTLPLRPPTRRPSNPDSLATRIAQINAQRGSFRNVTEEGLQTEIDTLQAAGLTGDEEEEPESCDTKSPDRLEQLYKSRMEIIQFAAQAHAEATYALDFVSLLLSKHTPRQAEISMSPILKQKAPLGSLDVDVIKQPEQSESSKKDIDTVSRGWKLENFDCAANKILKSATRLEEEVAAETKYWAEVLSIKEKGWKISRLPRERQTLGVHFGLLEATPIFRDRGLAALRRANGGDLLLDQGLHVNRPRAMRVRVQENGHTVGSSPVKGLPSQPENLVESRIRHARDSLYEEELFHELNREARALLQHGIETKHNLVQFKASDTQQILIDLVDLNNPDLDVYEMSKSRAEDNLAESLATSLRILLSYAHRQNLRRRTQIPPPLKAGKRPTPEFPLLGPIVCFLQHRSEFQWMRSFLDDLRGTLKSAGLSFWYTASPASSINQSNPPSRSTPPPQPPSPIESLVSTFIGPMESFISGTFLSETSGFRLRISTHVAPNGYGTEFELFTNLPCMPGTNTTAPQRFGLRSELQDYMLYLFTIDLVYLIPPLSGNVNSPVAQTTHTHSHFRADTDDDEEDDIEDTASQPLFHLSSLSTITTYLAAWEPTFAKYGELTAYCPSRRRTKKLRVDLRRDRLVLRSGWVGGSECEGDEEGVDRVGRGGAGMVTDGKGAIAYVWRPGTGEEEEEEESKVKIDDGSEGEKSLQSVVLLMGAKDV
Length716
PositionHead
OrganismPolytolypa hystricis UAMH7299
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Polytolypa.
Aromaticity0.07
Grand average of hydropathy-0.524
Instability index59.40
Isoelectric point5.48
Molecular weight79991.04
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15441
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.96|      23|      38|     642|     664|       1
---------------------------------------------------------------------------
  642-  664 (42.36/23.95)	W.VGGSECEGDEEGVDRVGRGGAG
  677-  700 (39.60/21.94)	WrPGTGEEEEEEESKVKIDDGSEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.62|      16|     103|     501|     530|       2
---------------------------------------------------------------------------
  501-  516 (31.34/38.58)	YGTEFELFTNLPCMPG
  537-  552 (28.28/ 7.39)	YLFTIDLVYLIPPLSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     262.80|      64|     373|       9|      75|       3
---------------------------------------------------------------------------
    9-   72 (109.40/67.36)	PLR..PPTRRPSNPDSL.ATRIAQINA.QRGSFRNVTEEGLQTEIDTLQAAGLTGDEEEEPESCDTKS
  385-  446 (106.62/65.34)	PLK...AGKRPTPEFPL.LGPIVCFLQ.HRSEFQWM.RSFLDDLRGTLKSAGLSFWYTASPASSINQS
  449-  494 (46.78/21.88)	PSRstPPPQPPSPIESLvSTFIGPMESfISGTFLSET.SGFRLRIST.....................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.86|      22|      24|     208|     229|       6
---------------------------------------------------------------------------
  208-  229 (37.75/22.18)	RQTLGVHFGLLEATPIFRDRGL
  233-  254 (38.11/22.46)	RRANGGDLLLDQGLHVNRPRAM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      56.06|      12|      38|     271|     282|       7
---------------------------------------------------------------------------
  271-  282 (19.48/10.69)	KGLPSQPENLVE
  299-  310 (17.61/ 8.97)	HELNREARALLQ
  311-  321 (18.97/10.23)	HGIETK.HNLVQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15441 with Med17 domain of Kingdom Fungi
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