<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15437

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSNAVPQVFPSFQAGPSPLSPTSPPTEGVAKPSNPTHQPPDDRYSPHTPTSPPLMSLSSQNYASNFSATQVSPPQTASQSATIFSSPPSSTTMSTQTSQQPTLATTNSFPTPASSVSGQFAHVAPAEETDGAVKDASSRQSNDNNAEDLMDIDASSHRRTDHDRQRDDAGGTAALDENPMDVDHEMTSPARDGGLDPASLQEDIGTAFHVCKSSYTASGPNPSWDLVSLYGLGPVAASVARTDPVTGEKINRLRKSYEGKIKGLGLAGRNKPVKNEVAAPGTLRHMTLWPEEEWHNQKVYGKEIKVAESDSSFYKLLTRAMKMEPGRVPNHEFWEDALGHEKPLKHIDALKKPGGATPGPVRPTTQANGAAPVSTPTHNRESGRPKRTGKKRSYNDSSFVGYGEGFPDDGDDLDGGLYSNSEEGGRGSGKKKRKKDHISGVSPPLERGGSYGVGMFGVGAR
Length461
PositionHead
OrganismPolytolypa hystricis UAMH7299
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Polytolypa.
Aromaticity0.06
Grand average of hydropathy-0.835
Instability index54.69
Isoelectric point6.28
Molecular weight49070.33
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15437
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      85.61|      16|      26|      10|      25|       1
---------------------------------------------------------------------------
   10-   25 (34.19/13.39)	PSFQAGP....SPLSPT..SPP
   35-   53 (28.09/ 9.88)	PTHQP.PddrySPHTPT..SPP
   57-   74 (23.33/ 7.13)	LSSQNYA....SNFSATqvSPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     142.57|      41|      85|     272|     314|       2
---------------------------------------------------------------------------
  272-  314 (72.03/47.44)	PVKNEVAAPGTLRHMTLWPEEEWHNQKVYGKeiKVAESDSSF..Y
  360-  402 (70.54/40.93)	PVRPTTQANGAAPVSTPTHNRESGRPKRTGK..KRSYNDSSFvgY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.52|      14|      17|     135|     148|       3
---------------------------------------------------------------------------
  135-  148 (25.63/16.31)	DASS..RQSNDNNAED
  153-  168 (20.89/12.01)	DASShrRTDHDRQRDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.95|      14|      23|     184|     197|       4
---------------------------------------------------------------------------
  184-  197 (26.77/14.90)	HEMTSPARDGGLDP
  209-  222 (26.18/14.41)	HVCKSSYTASGPNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.11|      15|      20|      75|      94|       5
---------------------------------------------------------------------------
   75-   90 (24.24/25.62)	QTaSQSATI.....FSSPPSS
   96-  115 (23.86/ 8.00)	QT.SQQPTLattnsFPTPASS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15437 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GDDLDGGLYSNSEEGGRGSGKKKRKKDHISGVSPPLERGGSYGVGMFGV
2) MSNAVPQVFPSFQAGPSPLSPTSPPTEGVAKPSNPTHQPPDDRYSPHTPTSPPLMSLSSQNYASNFSATQVSPPQTASQSATIFSSPPSSTTMSTQTSQQPTLATTNSFPTPASSVSGQFAHVAPAEETDGAVKDASSRQSNDNNAEDLMDIDASSHRRTDHDRQRDDAGGTAALDENPMDVDHEMTSPARDGGLDPASLQED
3) PGRVPNHEFWEDALGHEKPLKHIDALKKPGGATPGPVRPTTQANGAAPVSTPTHNRESGRPKRTGKKRSYNDSSFVGYGEGF
410
1
325
458
203
406










Molecular Recognition Features






MoRF SequenceStartStop




1) KKKRKKDHISGVS
2) LDGGLY
430
413
442
418