<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15435

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMAESFSLPLRAVGQKATEPDPLPIRIAQINAQRGSFRNVTEQSLQEEIDAQRAAGVDAQEVAEAESEEVKPSDRLEQLFKSRAEIVEFAMQAHAEANYALDFVSLLVSKHTPRQAEISMSPYLKQRAPLGSLGIDIVKIPEKTEAVIKDIDDLSRGWKLENFDAAANKLLQSASRLEETVAAETKYWAEVLDIKDKGWKICRLPRERQTLGVQFGFMEATPTFRDRGLAALRRGNEGDLLLDRGLNTSSPRSLRVRVQQDDEIVGVSNLIRLEVGPDESFESRIRLARDALYEEELFHEINREARSLLHHGIESKQNLIQFQASDSQQILVDLVGLEDGVIDLEQQGHAEDALAETVAQSLRILLSHAHRQKYRRRTQIPPPVTAKRRPNPEYSLLQPAVCYLQHKSALQWLESFLDSITKTLQLAGLNCKYNIAPMVSINLPQISTTASSDPDAPPFIEKLVGTFVSPLESVTTGTFPSPTSTFKIRLTTTITPQTFGTEFELATNTPSIPRSNSISKPTRIGLRDDLKQLLLHLFTTDLVFLVPHLAGGTGLSSSHYFSRADMNQDEEDDFSDEIPASKPHHLTPWIPTSPENGELTAFAHALRRSKRLAVDLQVNRLAVRCQWLGGLDAPTGTEGDAENADGRAKEKESDKAESQGIIEYSWYADGTRQGADTIMRDGEKSLKEVLQIMSGDEEKGAI
Length701
PositionHead
OrganismHelicocarpus griseus UAMH5409
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Helicocarpus.
Aromaticity0.06
Grand average of hydropathy-0.441
Instability index49.77
Isoelectric point5.23
Molecular weight77981.87
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15435
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.32|      16|      16|     277|     292|       1
---------------------------------------------------------------------------
  277-  292 (26.88/16.04)	DESFESRIRLARDALY
  294-  309 (27.44/16.51)	EELFHEINREARSLLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.39|      12|     212|     410|     422|       2
---------------------------------------------------------------------------
  410-  422 (18.53/12.86)	QWLESfLDSITKT
  625-  636 (24.86/12.55)	QWLGG.LDAPTGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.62|      14|      16|     474|     487|       4
---------------------------------------------------------------------------
  474-  487 (25.81/14.21)	TTGTFPSPTST.FKI
  490-  504 (20.81/10.26)	TTTITPQTFGTeFEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.10|      13|      16|      28|      42|       5
---------------------------------------------------------------------------
   28-   42 (18.11/18.41)	QINAQRGSfrNVTEQ
   47-   59 (22.00/13.58)	EIDAQRAA..GVDAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.82|      10|      16|     159|     168|       7
---------------------------------------------------------------------------
  159-  168 (17.01/12.60)	LENFDAAANK
  176-  185 (15.82/11.16)	LEETVAAETK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.04|       8|      40|     149|     158|       8
---------------------------------------------------------------------------
  149-  158 (13.37/13.12)	DIDDlsRGWK
  192-  199 (17.67/ 9.72)	DIKD..KGWK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15435 with Med17 domain of Kingdom Fungi
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