<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15434

Description Uncharacterized protein
SequenceMIPHPSSHRPPRPVPPSRGPPSRPVVFPPPEGLPAIDPRLQQSTVIDLTEDEYGDVADIGRPAKRLRLDTGIDPPPLDHHQQFQQQHQHQANPQYRGQSAGGEAPESSINPLDLMNAFSSEQTARPPWSFRREMPRSVAGGTPDSAQWPRSVSLPPLPIRPWKYSPQERYRMGRMGSKDDMECMEVATKPYNIDVPSAAPRFADDKPADFSPWTGSHPEDVLSEQTAKQGFYDRVQVSSNESASAKPSLYPQFKHRSGLKVLSSVFAAALEKRQAHTRITDESKFKPPPRVTITDRRREEWLQSLADPSCPLRSLSRTIPHGIRGKVLLDQCLAKNVPIPRAMWLAKCVGANELRAFKRKGTSAAVASGLEAKWVRDWTVNVEQFIEGVIASFGDATWKFRISYAVRLSARLFLEHLLEQDHFVDWFLTSFDAASLENLPVWLLMVGVYWQSTVRYRRRGKRLAECLLEKLRLAIETDQNGNLSPLIRRLSRLVKTFALTHPSSFILPRTWSKYEGVLQSCLDLTLADDKAALEKIIDRNARVCRIKSDRAKSTGSPHQRLIQLLDSSSDLPTLSTECLNISLDYSVLITRIIEWSSTSFRYGLARIYTAVRLFRRWKKAGIDIDSHILAFLVQNHQKSGVRLLDVYHVISELVRSQSFSVGKYLQWLMARGVDSNVSSSEQRHIPGDIGLLGHLPSRRLPSHIWNLRNTLFSRAGFSVAAESDAIQQAKASIRRRLPNMFAESSPDGDAEMTDDVDLTSFTWTVRSELGQWLRDQVACHVTNNLKSAMDNDFANDIKSSALTPGEFFEVRYIMECLDDLSMLADVLKHASGSDDGTVLASAVDTLDYHFDSFNAIGATIDLFKSFVDAYTRMSKTELPIQDLISSLLNVGIRLPAEMSTVAVLRRDQVQRDRKLAMAASSPVSDHIADTLNTSNPTFTEELDQLLASGNSMDEATLARIFGTLSKRLESGSVGGRQCVNETARYFAQLRTFNAKYFDNLMIKWVIGILKSSPRPILSTILPPLIGVGCVTLHSFYVLAKALLHSESHRNAISDLAELRFNMIQLLDKKVSDENGSQGLVSYRFKIARQEYVKQYSGEALSLTQDLLEEVSKDGAESSLKQGGTDLVNATSIPLLCEIVVRQPGIVGADCADRLLEKFPACMNLTNQALSVLLGSRFENGLAAAEETIESINDFSLPFCLMKLRLLFASECDEDVKGRIYDFVFEAAKSNVQKGQSYWVDVVGTLHADAAQEIRQRAEEHLLSIVFSSDSVPPSPAFEPNTLPIPNVSALVYLRIVEDLSFSVPETGVPSLGPVLLEKMNLVLQKVAYLESSMSNANQDSDHSVTLRHSYAAQESAILFWFYIMLRLVSIHRSSFAPGALPKSDIADQTRLLISISCIALSRTLSSRDPSRPHLFPSTVPLPPTTFLQQTQPEPGTGVNTGTSTNLQVQALDVAATLLDPLPDDARHQCARFLRDRCPPFLHPQNDPRLLALLGPLGTDTQFSAPSQPQPQPQSQQLAPGTVGTPTPSPATPVTPATPTVAGAPAASQQQFYNASSFIPLDDPNSFAGKLRVQQRGRIVGPYPLRPWEMLEAAAPFVGVNDTAVSLGWFGARGVRG
Length1616
PositionKinase
OrganismHelicocarpus griseus UAMH5409
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Helicocarpus.
Aromaticity0.08
Grand average of hydropathy-0.253
Instability index51.48
Isoelectric point6.85
Molecular weight179153.66
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15434
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     448.50|     115|     218|      65|     213|       1
---------------------------------------------------------------------------
   77-  201 (189.24/119.09)	LDHHQQFQQQHQHQANPQYRgQSAGG......EAPESSINPLDLMNA...FSSEQTAR..........PPWSF.RREMPRSVAG...GTPDS.AQWPRSVSLPPLPIRPWKYsPQE.RYRMGRMgSKDDMECmevatKPYnIDvPSAAPR
  727-  779 (50.87/11.81)	......................................................QQAK..........A..SI.RRRLPNMFAE...SSPDGdAEMTDDVDLTSF...TWTV.....RSELGQW.LRDQVAC..................
 1394- 1488 (95.64/35.80)	.....................................SISCIALSRT...LSSRDPSRphlfpstvplPPTTFlQQTQPEPGTGvntGTSTN.LQ.VQALDVAATLLDPL...PDDaRHQCARF.LRD..RC.....PPF.LH.PQNDPR
 1496- 1588 (112.74/52.70)	LGTDTQFSAPSQPQPQPQSQ.QLAPGtvgtptPSPATPVTPATPTVAgapAASQQQFY..........NASSFiPLDDPNSFAG...KL.RV.QQRGRIVG..PYPLRPWE.......................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.38|      12|      15|     319|     332|       2
---------------------------------------------------------------------------
  319-  332 (17.12/13.19)	IPhgIRGKVLLDQC
  337-  348 (24.27/11.45)	VP..IPRAMWLAKC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     163.02|      54|     256|     243|     316|       3
---------------------------------------------------------------------------
  261-  316 (84.01/94.07)	VLSSVFAAAL.EKRQAHTRITDES....KFKpPPRVTITDRRREEWLQsLADPSCPLRSLS
  517-  575 (79.01/44.05)	VLQSCLDLTLaDDKAALEKIIDRNarvcRIK.SDRAKSTGSPHQRLIQ.LLDSSSDLPTLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.34|      31|     220|     398|     454|       4
---------------------------------------------------------------------------
  424-  454 (59.52/78.73)	VDWFLTSFDA...ASLENLPVW.....LLMVGVYW...QSTV
  860-  901 (37.82/10.49)	IDLFKSFVDAytrMSKTELPIQdlissLLNVGIRLpaeMSTV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.39|      15|      15|     220|     234|       6
---------------------------------------------------------------------------
  220-  234 (26.03/16.34)	DVLSEQ..TAKQGFYDR
  236-  252 (21.36/11.98)	QVSSNEsaSAKPSLYPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.46|      40|     256|     917|     961|       9
---------------------------------------------------------------------------
  917-  961 (57.95/53.62)	MAASSPVSDHIADtlnTSNPTFTEELDQLLASgnSMDEATLARIF
 1181- 1220 (69.51/47.44)	LAAAEETIESIND...FSLPFCLMKLRLLFAS..ECDEDVKGRIY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     170.69|      53|     101|    1224|    1283|      14
---------------------------------------------------------------------------
 1224- 1283 (77.50/69.46)	FEAAKSNVQKGQSYWVDVVgtlHADAAQEirqRAEEHLLSIVFSSDSVPPSpAFEPNTLP
 1329- 1381 (93.19/60.28)	LESSMSNANQDSDHSVTLR...HSYAAQE...SAILFWFYIMLRLVSIHRS.SFAPGALP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15434 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DVPSAAPRFADDKPADFSPWTGSHPEDVLSEQTAKQGFYDRVQVS
2) MIPHPSSHRPPRPVPPSRGPPSRPVVFPPPEGLPAIDPRLQQSTVIDLTEDEYGDVADIGRPAKRLRLDTGIDPPPLDHHQQFQQQHQHQANPQYRGQSAGGEAPESSINPLDLMNAFSSEQTARPPWSFRREMPRSVAGGTPDSAQWPRSVS
3) QNDPRLLALLGPLGTDTQFSAPSQPQPQPQSQQLAPGTVGTPTPSPATPVTPATPTVAGAPA
4) RPHLFPSTVPLPPTTFLQQTQPEPGTGVNTGTSTN
194
1
1484
1411
238
153
1545
1445










Molecular Recognition Features






MoRF SequenceStartStop




1) LPIRPWKYS
2) TEDEYGDVADIGRPAKRLRL
157
49
165
68