<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15432

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEFPAGALTSFHTIDGFVNLYWRLYISSTLSAPSSQSTTAENTILKCSNELKNCMLTLRSLGCLVSPVSNVFGLWVFSTSSNFDVLGPVYPEQGNLGNNAIVVGSTVFRNVASGVITAAECLKRLAFEPQASLLTTSAMQKQMSDNAFFTAIQRLTSYMSFYEAFISAVAAAIILHLTQQQKAIPLGNRVLFTSLDHNGNGSTTSVPSLGSQSTACLSMLETELTSKGRLLVSFKPISQYSIEQFASCHQSGSNVSIVSGDEKVWLAPNCTLCKFISMEDSETIGPVSKSTANENQPNFRKGQIQRARWKVAVVDCLQKFGLKVDNPDGESWVEVEVRRTPGRNSYNLPLQGDGIKSDASAPRRILWPARLCFKRITSPRQDVTDAIKYFSVEKDDPLQFAEHWINDASSRSQSLEGASGHEPEKQQKDSEKSPIKSEITDMPESLARTINYPDVQVANAVYPTPPGGILGSTIGVLVASEGPTSSTPNAFNSYQQNQNEIGYNENGTASAVFRSDNELVLPTVTPATDLGIGSGLYDTAGDEDLFGELDGENFDSKGITEADFNFFDDPDFADGNASFESNSGSQNILQGNFDSLPPPVPNTSGTSRVGTQQAGLLETPAPTAEAANHEGVTERVGVSPNVGVPEDDKSKMEIDQTSEVSTNVRRQPMSPPLSPVEIRKILFTDSSLATNYFNLPKSGPSNVTDVQHKHKHNHFEPVPFQRDIWSSDKKYTMDGRFWFMPERTKPVASYKLGAYPAAIPTIGLPSRGKKTGFGAMHGRSPGTPEDVVAENIEPSEIRSSDTSSDDSSQNSDSDYQSDSSSSPTWYTGTKRKRGIGEDGESTISSLEKPAPIPDVNDEGLGGDVSALLAIILYDSGSDLLPGYLSSQEDRINPVLAWREDTIQVAQLVVDQITQSSLQHCRNKIQRSGEDEWSSVLQYNPLDGEVMGEMARLDLKTYATLEEPQNTPPPRKDQAPPLRGPAGSIFKLCPPHVRVHRGNKFLEILPPAIGFWETFGLEPLRGEKDIMPFCLHPHGIAEAADAFLERLGLVYSSCNFGKHSRPSNLNGLIPWNANPSGERNYASIMHMLKLTCESLGSALSNLPSSNENIVIYIINPFPFETAIADISSAFLRLFNKYVGDTSRQSFRNLNELGLQIVPLPFVASSESLVVPTQTDYLRLALEVYSRCPPKDGSSDYLGSAPALTIAEPIPRIIPLKLSPDPVSPLEEIRCLHVAYSQSLDQRWVTAAWTDNAGQYQVNLSYCLFEGDLSARRPMSEIREDIWDATREIIEMSQSYWRVVLAKDGPVDPDEAEAWKSLVDTYNQRKTTQVEFTLVSIDTEPGLFFKLPTAQLQLSALGQQQQQQQQTASASGSGTTPVSTPRPSIPSPDPSSAAAAAATPPTDTQPVHSHLYSNPSLESDTDTILIDKSDETWALTLSHRPNTSLTRIPSLSPSLSPSSPPTYRPSLASGYLLRRSGTSDTDGLASLGVNIIRCPPRRIVDIVLKDVLRSYRDLATLARAKGIAHVQGDIKCLPWHIATAVKGQEVLSRIM
Length1549
PositionKinase
OrganismPolytolypa hystricis UAMH7299
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Polytolypa.
Aromaticity0.07
Grand average of hydropathy-0.360
Instability index53.15
Isoelectric point5.09
Molecular weight169034.30
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15432
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.35|      28|      40|     976|    1015|       1
---------------------------------------------------------------------------
  976- 1004 (49.93/57.94)	PLRGPAGsIFKLC.PPHVRVHRGNKFLEIL
 1018- 1046 (49.41/25.19)	PLRGEKD.IMPFClHPHGIAEAADAFLERL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.96|      36|      40|    1081|    1118|       2
---------------------------------------------------------------------------
 1081- 1118 (55.67/37.94)	ASIMH.MLKLTCESLGSAlSNLPSSNEN.IVIYIInPFPF
 1123- 1160 (54.29/28.91)	ADISSaFLRLFNKYVGDT.SRQSFRNLNeLGLQIV.PLPF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.57|      22|      70|     313|     334|       3
---------------------------------------------------------------------------
  313-  334 (40.58/28.20)	VVDCLQKFGLKVDNPD..GESWVE
  383-  406 (34.98/23.17)	VTDAIKYFSVEKDDPLqfAEHWIN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     206.44|      50|      70|     669|     728|       4
---------------------------------------------------------------------------
  669-  718 (86.75/41.51)	MSPPLSPVEIRKILFT..DSSLA..TNYFNLPKSGPSNVTDVQHKHKHNHFEPV
  740-  787 (78.71/49.60)	MPERTKPVASYKLGAY..PAAIP..T..IGLPSRGKKTGFGAMHGRSPGTPEDV
  790-  832 (40.98/15.40)	..ENIEPSEIRSSDTSsdDSSQNsdSDYQSDSSSSPTWYTGTKRK.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     240.26|      67|      72|     490|     561|       6
---------------------------------------------------------------------------
  461-  490 (35.86/14.91)	.............................VY.......PT.PPGGILG............STIGVLVASEGPTSSTPNA
  491-  562 (106.43/77.38)	FNSYQQNQNeigynENGTASAVFRSDNELVL.......PTVTPATDLGIGSGLYDTAGDEDLFGELDGENFDSKGITEA
  564-  634 (97.97/60.13)	FNFFDDPDF.....ADGNASFESNSGSQNILqgnfdslPPPVPNTS.GTSRVGTQQAGLLETPAP.TAEAANHEGVTE.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     251.17|      78|      81|    1306|    1385|       7
---------------------------------------------------------------------------
 1304- 1383 (126.31/77.11)	PV.DPDEAEAWKSLVDTYNQRKTTQVeFTLVSI..DTEPGLFFKL.PTAQLQLSALGQQQQQQQQTASASGSGTTPvSTPRPSI
 1384- 1465 (124.86/68.87)	PSpDPSSAAAAAATPPTDTQPVHSHL.YSNPSLesDTDTILIDKSdETWALTLSHRPNTSLTRIPSLSPSLSPSSP.PTYRPSL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15432 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DPDFADGNASFESNSGSQNILQGNFDSLPPPVPNTSGTSRVGTQQAGLLETPAPTAEAANHEGVTERVGVSPNVGVPEDDKSKMEIDQTSEVSTNVRRQPMSPPLSPVE
2) SALGQQQQQQQQTASASGSGTTPVSTPRPSIPSPDPSSAAAAAATPPTDTQPVHSHLYSN
3) SRGKKTGFGAMHGRSPGTPEDVVAENIEPSEIRSSDTSSDDSSQNSDSDYQSDSSSSPTWYTGTKRKRG
4) SSRSQSLEGASGHEPEKQQKDSEKSPIKSEITDMPESLAR
5) STIGVLVASEGPTSSTPNAFNSYQQNQNEIGYNENGTA
569
1353
766
409
472
677
1412
834
448
509










Molecular Recognition Features






MoRF SequenceStartStop




NANANA