<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15430

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGIIMDGTSVNGPGREVDRQLVDGTLSTTTSLAPHNNGNYSNGPSHTEDTTRLSNPSFDASLPPELVHISHGFFSLGHLINRAAQQCWNDLTDLIAELADPQSTAAHAAATPISTTNGKYTPSQSATENAQRKLRVLEFAQAKRADFIKILVLSQWSRRAADVSRLIDIQAFIRMRYDCYNGAIVSIGEMKRDLVRAQTANPDLAMALEVLSTGRVAAMQESSFVPPKPLTPKRMLKTLKKINKTIRTRLVLHDQIPSAFTNYLIHDGRVTFKVPTEFEVDLSIAQENYSSQFFFVDIRFLFSPSPPKPTGRLLDELDNRVNAILMHSGLTGCYNLLHNLVLSNKITILFHQAIELARGHWLDTLRVEVLHRTLVVQYWANRPGPKSWVEIGIKSGRRKDQTQDGSAIENPFLGLRWMRDNKEVESKYIKFDTELLSMEAVLRSVTALHISFLLESTYTRLSQGRLYASGALSVSLQMSTSEPGDCFFDVQLTKGRNLRVMIEPVSGAIVFRPTPVLLNRHDIDRSFERPILDDILFRISRLRSAAVIEEVESLADALGWEIVNSRDIKNEDLRRIFPPNILRAVLFFRKSWECNWGVAYTCSMDGDNWWVVELRAPSSDEGPVSPQSARMVTGRFGGLPERLHYGSFGRLDHALSGMLAIHANARYLSELHAVHHFPPVQELSLGPHLQVPSISIRFRSRSLPSWLQISPPIITNKNPAINDTVRLSFQGIDLSTQCAILLAHGSLSREIKDLALPAAHMDPTITFQPNGCGFAMRFLTRVGQPMIIQLLARLQQLERVISTLETLKQKSLKPLSVNLSKIKFAYAADEDAWASINFNYHEQALASDMNPITLLSKQTPLMLLRMSIDFHPQNPHRRIKDSLSATFNGLRPGAGAGIGLEAVLQLLVITLPVLKALERMTTESHGGHPTNSGLQITARSSKTFLIRYPSIRYRFCIHAGLRRDRVVWILREMTIAPDKVDRQPLENKLKEQIYGARGDGWQGLGNGAIAECEKVGDLLSTLHGVIADYISSETVGGSGSNTLGSRNGASGGDPGSGLGGNGGSSGGGGLGPEGRKAPQTQLSGRGVADNKARPMPGQTGMGIDMQGRLGGLGGSNIPTSASNGMLMGTQTQTQTDAKAVKQNPKIPHNNKNNNATGPMVSGNNGNGNSSGGNKDVDFIMID
Length1183
PositionTail
OrganismBlastomyces parvus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Blastomyces.
Aromaticity0.07
Grand average of hydropathy-0.247
Instability index40.10
Isoelectric point9.19
Molecular weight130025.91
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15430
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      69.98|      13|      52|     996|    1008|       1
---------------------------------------------------------------------------
  996- 1008 (27.01/12.34)	GARGDGWQGL.GNG
 1037- 1049 (22.66/ 9.18)	GGSGSNTLGS.RNG
 1050- 1063 (20.32/ 7.48)	ASGGDPGSGLgGNG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.70|      20|     104|      94|     138|       2
---------------------------------------------------------------------------
   38-   57 (38.05/50.66)	NGNYSNGPSHTEDTTR.LSNP
  118-  138 (30.66/12.90)	NGKYTPSQSATENAQRkLRVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     222.39|      71|     104|     378|     449|       3
---------------------------------------------------------------------------
  378-  449 (117.67/85.29)	QYWANRPGpKSWVEIGIKSGRRKD...QTQDGSAIENPFLGLRWMRD.NKEVESKY...IKFDTELLSMEAVLRSVTAL
  478-  555 (104.72/70.31)	QMSTSEPG.DCFFDVQLTKGRNLRvmiEPVSGAIVFRPTPVLLNRHDiDRSFERPIlddILFRISRLRSAAVIEEVESL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     132.46|      34|      54|     855|     888|       9
---------------------------------------------------------------------------
  855-  888 (59.89/32.95)	LLSKQTPLM..LLR.MSIDF...HPQNPHRRIKDSLSATF
  907-  945 (45.91/23.72)	LLVITLPVLkaLER.MTTEShggHPTNSGLQITARSSKTF
  961-  984 (26.66/11.01)	GLRRDRVVW..ILReMTI.....APDKVDRQ.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     168.51|      51|     470|     624|     681|      10
---------------------------------------------------------------------------
  624-  681 (81.59/68.72)	PVSPQSARMV..TGRFGGLperlhyGSFGRLDHALSGMLaIHANARYLSELHAVHHFPPV
 1095- 1147 (86.92/54.48)	PMPGQTGMGIdmQGRLGGL......GGSNIPTSASNGML.MGTQTQTQTDAKAVKQNPKI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15430 with Med14 domain of Kingdom Fungi
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