<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15429

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPMIMEDGIDVDDLFGDPASLELGLDAAAPSIKGLPQRIDELRSSGCCQKIAWSKLGAIAYISQDGQKVFLRYLHCRPDDGKWALSDEAPINQVTEIHGGHTIAHLLWNEAGTELAIVDSSGRISIVAILTAVNTVNPARQPSLDPDDDWAQPVGLLWMNVNRSLFAFHKATRTNDRWSFPAYRRRPLGLLHPANKSGLVLVTKSGHIKLIYQNPDLKWQEISAELKTIGYLDGTLTHAAMAPAEGGGISIATHSKCGKICFYRVLVKWDPPEWDQVPKPGVPNIVFPKPSFQVLYTKTETLDTVFHPPGHEMDNLSGFSQANWAIYNLTHLEIITASQVLPDTQTAAGPCILAVASVPAQNQLGQTPPSGPSSVVIRWQLDTMIQTLHSSFDDVASKKAASNPKSRVVFKRQEDIYFDRYVLSIDYAEAGSVLAVTYDDSSISFFDARSMKPINENEDVNVVTSMPNAGFTFPIDASGLHIAFSPSGCLAVVLDGEWQLHFRHMEHSFGMEDGMYNNGKFTCAIAALALGYVRACGSDTSPDDILTIIVRQLNPDAQRAFVTEVYSILFMSVDFTEQDKLMNNQSIQKGLSMQAVLGFRSRYQPRALTSAVPWAILNIRHIMMLFLTFSHYLKNGRDSTPYEPEVVRMLLGNTKWILDLAKYIVDELFEIADTIPADRTSFSLPNKTYESLPLVLILSSVPRSFLRHIFRYLNRFPATFKAATNLSGESYQLYASINAAITTSTIPLDTCEKFLAHADSLIARSYQAAGYGNADRNTPERELLITCTVPPVLQPAVMGILTETMPLVVRREVDRMTLATGDYSWLGVGGDKRTEVFKRRYDVDVLKRKVLSGGGGGGGGLVGRELPKRRCVRCCEVSEDVALPRSISTYRWIGKIGVLRSCVCGGSFAMEGGERPG
Length917
PositionTail
OrganismHelicocarpus griseus UAMH5409
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Helicocarpus.
Aromaticity0.09
Grand average of hydropathy-0.094
Instability index43.88
Isoelectric point6.19
Molecular weight101195.60
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15429
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.10|      31|      53|     191|     222|       1
---------------------------------------------------------------------------
  191-  222 (51.48/40.21)	LHPANKSGLVLVTKS..GHI....KLIYQNPDlKWQEI
  241-  277 (47.62/32.04)	MAPAEGGGISIATHSkcGKIcfyrVLVKWDPP.EWDQV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.60|      25|      53|     471|     500|       2
---------------------------------------------------------------------------
  471-  500 (36.95/39.34)	FTFPIDAsgLHIAF........SPSGCLAVVLDgewQL
  521-  553 (35.65/20.84)	FTCAIAA..LALGYvracgsdtSPDDILTIIVR...QL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     154.87|      40|      48|     678|     723|       3
---------------------------------------------------------------------------
  603-  636 (44.83/27.55)	...........YQPRALT...SAVP....WAILniRHIMMLFLTFSHYLKNG
  678-  723 (57.66/58.73)	DrtSFSLpnktYESLPLVLILSSVP....RSFL..RHIFRYLNRFPATFKAA
  729-  769 (52.38/35.92)	E..SYQL....YASINAAITTSTIPldtcEKFL..AHADSLIAR...SYQAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.09|      31|      53|      37|      67|       8
---------------------------------------------------------------------------
   37-   67 (53.43/36.98)	QRIDELRSSGCCQKIAWSKLGA.IAYISQDGQ
   92-  123 (47.66/32.20)	NQVTEIHGGHTIAHLLWNEAGTeLAIVDSSGR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15429 with Med16 domain of Kingdom Fungi
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