<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15418

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMASNEDWRTPAFRQKVISQIEEAVKRSGNPNVMMKNPSDMENQVFLKAKTRVEYLAYVARLLVYIRDIRPTAPGQQQAQAATMNQPGMSRGLQFPSSQLNKPQAVSTIGAQSTLQQVVPLGQVQQSPMAPQQVFYNKSGITQEQILAQHLQHQQQQTPQQHQLTSQSMMTPQAMSVNSQNQGGHHQISQSQSYVPPNQGASPMPVQQQSVHQVPQSKHPVQGRMPHVPSPAAGQNISSNSMRAPTPSSSLTSQATIAPSPAPFVPSPATHPSPSPQHYIPASPAAPTSVPTPSTMNVQSPASVPNPASVGPPAASPAQLNPAEEQAYLDKLNELKPYVEPLTKMINKLNRASGEKEHSSLYKLKHLYDILTNPAKRLPLQALENSGNVLKKLIPITTPPAPPTPSGNATSSASTTSVVTTTSQAVPVVPSAPIQTIYKPLFDAVTKHAKSPMLGHTLKRTFTPLLQAMEGPPILPIPPPAKRVKVTGEIPKKCTVPHVLQGELARLCSRFQVRSGASSGAVQSNTLLECSINDLNLPAVPPIEISVPQNYPYSSPECKTANYNANPFLQKVQRQLSSKLKCMPEMYSVTSVLNAWESSIRQACLAEVAVN
Length610
PositionTail
OrganismStylophora pistillata (Smooth cauliflower coral)
KingdomMetazoa
LineageEukaryota> Metazoa> Cnidaria> Anthozoa> Hexacorallia> Scleractinia> Astrocoeniina> Pocilloporidae> Stylophora.
Aromaticity0.04
Grand average of hydropathy-0.442
Instability index76.81
Isoelectric point9.66
Molecular weight65875.44
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15418
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      99.41|      21|      23|     249|     269|       1
---------------------------------------------------------------------------
  249-  269 (39.69/14.64)	SLTSQATIAPSP.APF.VPSPAT
  272-  294 (32.65/10.62)	SPSPQHYIPASPaAPTsVPTPST
  296-  313 (27.07/ 7.43)	NVQSPASV.PNP.ASV.GP.PA.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     116.07|      26|      51|     320|     345|       2
---------------------------------------------------------------------------
  320-  345 (43.84/30.86)	NPAEE...QAYLDKLNELKPYVEPLTKMI
  349-  371 (35.40/23.46)	NRASG...EKEHSSLYKLKHLYDIL...T
  372-  399 (36.82/24.70)	NPAKRlplQALENSGNVLKKLI.PITTPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      98.91|      22|      22|     150|     171|       3
---------------------------------------------------------------------------
  150-  171 (43.59/16.94)	LQHQQQQTPQQHQLT.SQSMMTP
  174-  196 (30.94/10.05)	MSVNSQNQGGHHQISqSQSYVPP
  226-  244 (24.38/ 6.47)	..HVPSPAAGQN.IS.SNSMRAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      83.47|      22|      22|      79|     100|       4
---------------------------------------------------------------------------
   73-   93 (31.62/17.05)	.PGQQQA......QAATMNQPGMSRGLQ
   94-  115 (33.38/18.47)	FPSSQLN......KPQAVSTIGAQSTLQ
  118-  142 (18.47/ 6.51)	VPLGQVQqspmapQQVFYNKSGITQ...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.11|      27|     113|     426|     471|       5
---------------------------------------------------------------------------
  426-  466 (40.36/48.75)	PVVPSAPiqtiykplfdavtkHAKS.PMLGHTLKRTFTP.LLQ
  472-  500 (41.75/15.97)	PILPIPP..............PAKRvKVTGEIPKKCTVPhVLQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15418 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KKLIPITTPPAPPTPSGNATSSASTTSVVTTT
2) PGQQQAQAATMNQPGMSRGLQFPSSQLNKPQAVS
3) QILAQHLQHQQQQTPQQHQLTSQSMMTPQAMSVNSQNQGGHHQISQSQSYVPPNQGASPMPVQQQSVHQVPQSKHPVQGRMPHVPSPAAGQNISSNSMRAPTPSSSLTSQATIAPSPAPFVPSPATHPSPSPQHYIPASPAAPTSVPTPSTMNVQSPASVPNPASVGPPAASPAQLNPAEEQAYLDKLNE
390
73
144
421
106
333










Molecular Recognition Features






MoRF SequenceStartStop




NANANA