<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15417

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMAAPRPLKRPRLGQPDVYPQDSKQREDELTEENVKKGFSYQPLPFSSGTNEYGSAKDIMSNVPLSKFAQSFNAILVEKQKQNTFTSQDGSKRKVQPVKDNFVPVHITARSRPFISSWFQDLAGNKPLTVLAKKVPIFNKKEEIFNSLCEYSIPMLRAAWFIKISSAYNTGINESKGKKRIMADPAQEWTHALTKFLKDQLSKIADFYQGHFAGITSSQHQQRMTPEVEQALKQWNYTVRLSHWLYEESLLDRQEFLQWLLDLLDKSKNADDLLLKYLIPLLLRYVDQIVLSQTLARVLAQVCSKKLSTLYSAAEQMQSEQQNQGTSSSNRTSTSSVPSPVLSITPESGSSLTPMNPQSLPVLSQYKTCPQHHALVLSLSSVLQTIAMCCPSALIWNSIPCGGSSNGLASSASNSTAANTDAAANKPAVLGSPLDRLPIAPSSMPLPSPGSTQTSLNSELLSVLLASEEEIKTRSKAVESHWSPDKYQDKSSVLAVKRVLNTLEILDRYNFNRADSTSSIDSLYSKIFADSIKTGGQASATDEAIALLLFEWAVSKYRVGKFRALAVAKILQRRQTEILEERESSQEQGEEGTSSNAVTTATSTVPPFQKVLMNFLDNYAPVVDGGYQHNKTHPSFAQLTLLFGELIRNEVFSHNSYMYTLISRGDLQPTPPVSIPSPPRPVIQSIEHPPEADPMGIEECVQEGDAQGGIDIHGLTCQEDLGGKDSSSDSELKMSQQLLDQELLVHQNRLIQLLDQGDNEIFADQEAPILTADLSAVASNTKLEPSLANPSSLTADQRDNSLMDSTCTLPKKSQHAQYAQHFPIPAENVTAHESNQRLILLYGVGKARSQAIATTKEVMKALCNMLNDLGKVDDAGLCTDQGQNSEYLVLKRERDEKRAVLYSKFSNLTCFDQYLAVAKCNNILRDQKTKQPKMFGLVMPTPTLSQLEFLYDLFELSGDVHGLLDFVAYLLMPSEEDISTAQLPQVKTVVGTLPTKSVVVVAMLRKYHACLMLLPEHTTRIFRGLLAAVENIAYPGICSSPERCILALLFDLYSSCAHLRSKYADIFSTAFTKIKQAVCSSTTPSACTEPYEPKFMAEYFQNPRTKRLDGIWEYLLNHEKPCDVYSFVCNAMMNVCNCQNSERLYDIGVLCAEVTAHHGRLSSEWLGVLRALCCSSNSSSGFVDLLLEVDVGDLSIHESVATFTALLIARSCFSLEDVIYHVALPSLLAALPSGVENQEAEPGARLTCHLLLRLLDESTDVMSHDHSSALKFPFKSSHDHHLLSAAHDSIRIGPVLAVLKAMLKLSEAGKAGDSGTTSTSDTTRDDSFRSLFSNRLDDFMDSTSSTGDIFPPPLASSRSAMETSNISVFAGFALQVICRQEWVRERCLQDPQILCSPEHLLDPAISPNQARKLLHLICYPAGVPSSIGGLIANSNDMETIHEAASRILQNLDQWSLRKSWLELQLMIKQVSKEETGPLLDAVATSAMSVFVQRHDTTPLATAHSNQKSVVVKGPEWLVAPLISKLSNSVQGRLLKAAGEVLDTKQWWKEHSAKSSVPTLVHTQPFLSLVLACLKGQEDQRDGLLASIQRQLTHLLVSSVEERCPTDLKSKEVLQEALHLRISLLGAMFDTIQRSSQLSSDWATLLFQLVSSGTITADSLPSKKELLTNVLDMVSVLISVRVIDQCTGYGVSANQCCVQLRFRELLTNVLDMVSVLISVVSNTESPHGQSAEESRKAAFTLFKKLKRELAGKSPIDIMQQCKQLLPLPSLSHNVFTVSPVKDTPANPGQTAEKAPTGGPSTSQGLQITGKQRISAWELMEGYKNPSPLSWAWFGAVRIERKPLRYEQDFRRLLHHTHPRRRPLSYFLSPAPDREDEQDEEEDRTELDAAAGDKTSQPSTPQTPADNKGQIPLITASVAPGLNVPTALNVPQSLPANQMAMSDGGKIRKPLKRTKRATKPPGQGAMQKKYLLQQQQQQQQPQQQQQQQQQYFQNQSAGMMLPSQNPQQQQQQQAFFQQGPQQRGLQVQPGMQPQQQQRLTNPSPLTDLRSMLTSHPSQNPMPHQAPRPNASVTQQLLQQMMRKQQQKQQQQKQPQQQQQPQQQQQQQQQQQHALQFLTQNSLIKQQLQMGQTQMSQQQQQQQQPLTNQQLRHLPPNNQLQASQAAGQIHTNQQYTFTQPQRPAALGRTQVTTRPNLVSTSSTPTTMALPSSLAGMVTQQQPFNSAAFQGLTVSPALTRPIQPQQQQLVQQQQQQQQQQQRQQQQQQIQQQQQVQQQPQFSLTGQRAIQPQPQSQATMQHQLPVSSGHAQMNPISQIQPTFQNQYQQQSTVNRQQQQRLFAFTQAQQQQQQQQQQQQQHQQQQQHQQSRVPTELMMRLQRQLSAGPELSMASAQFTPTADLTLQRQLSAPSEVGLQRQDITQFTRQLSTPAPQDLTQQAQQQQYTGNPQYQTPQF
Length2451
PositionKinase
OrganismStylophora pistillata (Smooth cauliflower coral)
KingdomMetazoa
LineageEukaryota> Metazoa> Cnidaria> Anthozoa> Hexacorallia> Scleractinia> Astrocoeniina> Pocilloporidae> Stylophora.
Aromaticity0.06
Grand average of hydropathy-0.477
Instability index58.06
Isoelectric point7.42
Molecular weight272864.77
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15417
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     310.59|      23|      23|    1970|    1992|       1
---------------------------------------------------------------------------
 1967- 1987 (40.70/12.51)	YL.........lQ...........QQQQQQQPQQQQQQQQQ
 1988- 2011 (34.28/ 9.26)	YF.QN....QsaG...........MMLPSQNP.QQQQQQQA
 2012- 2035 (29.58/ 6.89)	FF.QQ....G.pQ...........QRGLQVQPGMQPQQQQR
 2077- 2100 (36.35/10.31)	MM.RK....Q.qQ...........KQQQQKQPQQQQQPQQQ
 2113- 2140 (29.86/ 7.02)	FLtQNslikQ..Q...........LQMGQTQMSQQQQQQQQ
 2223- 2254 (30.39/ 7.30)	AF.QG........ltvspaltrpiQPQQQQLVQQQQQQQQQ
 2255- 2276 (38.63/11.47)	Q..QR....Q..Q...........QQQQIQQQQQVQQQPQF
 2335- 2357 (39.40/11.86)	LF.AF....T..Q...........AQQQQQQQQQQQQQHQQ
 2418- 2439 (31.39/ 7.80)	QF.TR....Q..L...........ST.PAPQDLTQQAQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     134.48|      32|      36|    1662|    1693|       2
---------------------------------------------------------------------------
 1622- 1657 (25.29/12.95)	..LLGAMFDTIqrsSQLSSdwATLLFQLVSSGtITADS
 1662- 1693 (56.18/39.33)	KELLTNVLDMV...SVLIS..VRVIDQCTGYG.VSANQ
 1701- 1731 (53.01/36.62)	RELLTNVLDMV...SVLIS..V.VSNTESPHG.QSAEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     126.00|      24|     256|    1895|    1918|       3
---------------------------------------------------------------------------
 1777- 1796 (27.28/12.18)	P.VKD....TPA.NPGQ....TAEKAPtgG
 1797- 1824 (29.91/14.16)	PSTSQglqiTGKQRISAWELMEGYKNP..S
 1871- 1894 (25.73/11.02)	REDEQ....DEEEDRTELDAAAGDKTS..Q
 1895- 1918 (43.08/24.05)	PSTPQ....TPADNKGQIPLITASVAP..G
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.20|      17|      23|    2367|    2386|       4
---------------------------------------------------------------------------
 2367- 2385 (27.83/17.45)	PT.ELmmRLQRQLSAGPELS
 2393- 2410 (28.37/10.79)	PTaDL..TLQRQLSAPSEVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.55|      18|      23|    2280|    2297|       5
---------------------------------------------------------------------------
 2280- 2297 (33.59/14.54)	GQRAIQPQPQSQATMQHQ
 2303- 2320 (33.96/14.79)	GHAQMNPISQIQPTFQNQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     106.25|      23|      23|    2143|    2165|       6
---------------------------------------------------------------------------
 2143- 2165 (40.94/21.70)	TNQQLRHLPPNNQLQASQAAGQI
 2167- 2187 (35.43/17.55)	TNQQYTFTQP..QRPAALGRTQV
 2194- 2213 (29.87/13.36)	VST..SSTPTTMALPSS.LAGMV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15417 with Med12 domain of Kingdom Metazoa
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