<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15416

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMASTEVSADSGTKINLSMLVDFLLQKTYHDLTVLSELLPRKSDIERKIEIVQFASKTRQQFVRLLALVKWAASADRVDKCQAISTILDKQSMLFVDTADMLARMSRETLVKARLPTFCLPAAVDVLTGGTYPRLPTCIRDKIVPPDPITTVEKTKTLQRLNQVIQHRLVTSKLPPEMGQMIIADGRVKFRVEHEFEVMLTLMGDDSSIPWRVLSIDFLVQDMETGDGKSLVHALQTQYIHQLVQSRLFAEENPLVDLYKCLHSFCLSLQLQVLHFQAKQLMAERWGDNIRIEEYAIGKTLVVSYWRNKSPVQQGQKTGHKITICEDSIDDPTSLCVQHSPALPFEFNQDCISKVIPGDLYIEKLLTHTIKAQSNVKLKGLLQMLMQDSSLKSKVTLDDFCPSLVIQVMPKPTPAETLIVTVGNRNGIFQVSLGSGEDNAVCTELENTLNTNLDQFLTVLRDARCQLYVKRYMKSTVDLPVTVSSSLPVVNLADHKLSQLSKHKLFIQFRRHPSYCLVVEVLCNEDSEEAATKYHLLKVKPTFGDEVNEASASTDSSNGDQKPQRVEVKKEGIKSQDRTRQSCDGARNAIAETKQKRRALFLTAGHMVTLNAQKLTDYAGTPLEGFLSSREDGEGRKRKLDSSGEEPHGNKKLKTLKDVLEEGRNNSTYDPTMGHVIAICHARMPFVQLREELSRHKIIDQGLTSEAGVGFAIRLSNLPLSRDCDASLVPAPQPSVLDCVLRLPDESQGTCLLEMIMDNCPLEGLSTSEKGPTRHVLFEYKIQEGKARNASNNKGGEGDSDWAKLVVGKLLNDWYSVCKLYRHAVELDTFLKDSQSHFRHMCRVYSYNYKQLTLQYDPDKQSLVTFEWSVEQSQFVLTFGYCGSSLSANPHSYTARHLQQEFNTHQNLPYIVQILHETFRPLSALAKLSNKPVLGIHVYRPLTAWRKFTVLPQSSTHVLLVYRNSNATEIRFQAKNLVAIRDASYSVVDPSKGRGLPPTPNLKVFLQMYVDDVAKTGGITSRNASTTDDEAPPSPINMETDAPVIEAQFTSPQPVPGTANLTASPMIPRTSPQAPAASVNVPSPFSASPNVHSPGNIYGVGSPAAQLSAFLQPSPAAPQSLAQSPAGSLGLPVLSPATSHQFVTPSLGGSSPALSHSIPVTSPGSWPMSPQFTGSGQGSKYRPSPTPQPMPSGTGLKQPTTPPRPLTARTWAATVPTILSHKALIKLCTPVPVPCSVRHGPPAMVSPLERFLCCMQLKRYLTRIIQDELASKLSLLRNELTNGLAFKTNQPTTNLQYFLSIDPSYTALRLNVKPPPGQESSWKDELSTLERFFETRVACPPYKTSALTAFARLLCAPANILRDCIKIMKLELVRGSSVESLPRYLGLKSHYTHCH
Length1394
PositionTail
OrganismStylophora pistillata (Smooth cauliflower coral)
KingdomMetazoa
LineageEukaryota> Metazoa> Cnidaria> Anthozoa> Hexacorallia> Scleractinia> Astrocoeniina> Pocilloporidae> Stylophora.
Aromaticity0.07
Grand average of hydropathy-0.271
Instability index48.92
Isoelectric point8.72
Molecular weight154543.63
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15416
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     325.55|      62|      62|    1045|    1106|       1
---------------------------------------------------------------------------
  900-  976 (54.68/23.58)	..EF..NTHQNLPYIVQI..............lheT....FRPLsaLAKLSNK.PVLGIHVY..R..PltawrkFTVLPQssthvllVYRNSNATEIRFQAKNL
  986- 1043 (29.79/ 9.37)	VVDP..SKGRGLPPTPNLkvflqmyvddvaktggiT.....SRN..ASTTDDEAPPSPINME..TdaP......V.............................
 1045- 1106 (106.26/53.03)	EAQF..TSPQPVPGTANL.................T....ASPM..IPRTSPQAPAASVNVP..S..P......FSASPN.......VHSPGNIYGVGSPAAQL
 1113- 1152 (39.68/15.01)	.........................................SPA..APQSLAQSPAGSLGLPvlS..P.......ATSHQ.......FVTPS..LGGSSPA...
 1156- 1198 (32.24/10.77)	..SIpvTSPGSWPMSPQF.................TgsgqGSKY..RPSPTPQPMPSGTGLK..Q..P....................................
 1199- 1246 (62.90/28.27)	......TTP.PRPLTAR..................T....WAAT..VPTILSHKALIKLCTP..V..P......VPCSVR........HGPPAMV...SP....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     379.13|     102|     133|     164|     273|       2
---------------------------------------------------------------------------
  164-  273 (160.90/110.79)	IQHRLVTS....KLPPEMGQ...........MIIADGRVKFRVEH....EFEVMLTLMGDDSSIPwRVLSIDFLVQdmetgdgKSLVHALQTQ...YIHQLVQSRLFAEENPLVDLYKCLHSFCLSLQLQVL
  296-  408 (137.90/78.42)	IGKTLVVSywrnKSPVQQGQktghkiticedSI..DDPTSLCVQH....SPALPFEFNQDCIS...KVIPGDLYIE.......KLLTHTIKAQsnvKLKGLLQ..MLMQDSSLKSKV.TLDDFCPSLVIQVM
  458-  521 (80.33/42.59)	................................VLRDARCQLYVKRymksTVDLPVTV...SSSLP.....................VVNLADH...KLSQLSKHKLFIQ.......FRRHPSYC..LVVEVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.35|      15|     138|     621|     636|       3
---------------------------------------------------------------------------
  621-  636 (24.02/17.43)	PLEGfLSSREDGEGRK
  760-  774 (29.34/16.27)	PLEG.LSTSEKGPTRH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15416 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ATSHQFVTPSLGGSSPALSHSIPVTSPGSWPMSPQFTGSGQGSKYRPSPTPQPMPSGTGLKQPTTPPRPLTARTW
2) GGITSRNASTTDDEAPPSPINMETDAPVIEAQFTSPQPVPGTANLTASPMIPRTSPQAPAASVNVPSPFSASPNVHSPGNIYG
3) SPAAQLSAFLQPSPAAPQSLAQSPAGSLGLPVLS
4) TPLEGFLSSREDGEGRKRKLDSSGEEPHGNKKLKTLKDVLEEGRNNS
5) VNEASASTDSSNGDQKPQRVEVKKEGIKSQDRTRQSCDGARNA
1136
1016
1101
620
546
1210
1098
1134
666
588










Molecular Recognition Features






MoRF SequenceStartStop




NANANA