<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15410
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MASGLAVDIAIESLLESEVEEISRDGQEKYVPQLSMSEKLAKLAHKIDFLSDVKGHEMDTDKEDDEKSLITFQPSLWPWDSVRENLRKSLTEVCVLSDVLNVVRDKKYLVLDPVSQNQANPKPTLSLITKKKGLCNAADILLQGAQRMEDAVKERADHTIRQLGSNAKDFHSELMMLRKRWRLKRTGTSITGDLTYRSAGSQFRNPGLFEVSKATRAEDKTEQSTPDNRALEVTVGSDLEGTAEIRVAIVESGKELQIASVRGLMSGCYDNMPTVIPSWQQKLESAQSNLFCKELFMQLSQGAYNTKENRPHFVMANEIRAEIFPGTDLCITYSCRKNSSEENSSKVAQKDRAPRAYSLEYSLHSLLRKQHLKTHSLPTPHPVTAHPMQGGSKRLRLAGASALTTVEVAPNLQSESLLETVLKISRHKVLQKRAVEVIDGLKSRLNDPCITCHWSSVGSDTNTSATLHITSPEVGHLARSSFQVHVGVGEIRVVSADGASVHLPTHPQDLEDFILSQVCNHRLTVANSLAQSLGWHVIHCSRHVGTGAKERQGHVGGLMIKSPNGNKVVAVRTGPASGVSVLVRRPQLPNGVAPELLGDMNWKSLGGHFMEVHWSKMPGRTFVQRIFLLLAIEMY |
Length | 635 |
Position | Head |
Organism | Stylophora pistillata (Smooth cauliflower coral) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Cnidaria> Anthozoa> Hexacorallia> Scleractinia>
Astrocoeniina> Pocilloporidae> Stylophora.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.356 |
Instability index | 42.96 |
Isoelectric point | 8.53 |
Molecular weight | 70281.41 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP15410
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 75.93| 24| 116| 320| 345| 3
---------------------------------------------------------------------------
320- 345 (41.85/36.79) RA.EIFPG.....TDLCITysCRKNS..SEENSS
433- 464 (34.08/22.23) RAvEVIDGlksrlNDPCIT..CHWSSvgSDTNTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 164.95| 51| 402| 153| 203| 4
---------------------------------------------------------------------------
153- 203 (89.39/62.28) KERADHT....IRQLGSNA.....KDFHSELMMLRKRWRLKR.TGTSITGDLTYRSAGSQF
549- 609 (75.57/51.47) KERQGHVgglmIKSPNGNKvvavrTGPASGVSVLVRRPQLPNgVAPELLGDMNWKSLGGHF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 67.08| 21| 115| 403| 427| 5
---------------------------------------------------------------------------
403- 427 (26.31/28.76) LTtveVAPNLqSESLLETVLKISRH
523- 543 (40.77/27.26) LT...VANSL.AQSLGWHVIHCSRH
---------------------------------------------------------------------------
|