<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15410

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMASGLAVDIAIESLLESEVEEISRDGQEKYVPQLSMSEKLAKLAHKIDFLSDVKGHEMDTDKEDDEKSLITFQPSLWPWDSVRENLRKSLTEVCVLSDVLNVVRDKKYLVLDPVSQNQANPKPTLSLITKKKGLCNAADILLQGAQRMEDAVKERADHTIRQLGSNAKDFHSELMMLRKRWRLKRTGTSITGDLTYRSAGSQFRNPGLFEVSKATRAEDKTEQSTPDNRALEVTVGSDLEGTAEIRVAIVESGKELQIASVRGLMSGCYDNMPTVIPSWQQKLESAQSNLFCKELFMQLSQGAYNTKENRPHFVMANEIRAEIFPGTDLCITYSCRKNSSEENSSKVAQKDRAPRAYSLEYSLHSLLRKQHLKTHSLPTPHPVTAHPMQGGSKRLRLAGASALTTVEVAPNLQSESLLETVLKISRHKVLQKRAVEVIDGLKSRLNDPCITCHWSSVGSDTNTSATLHITSPEVGHLARSSFQVHVGVGEIRVVSADGASVHLPTHPQDLEDFILSQVCNHRLTVANSLAQSLGWHVIHCSRHVGTGAKERQGHVGGLMIKSPNGNKVVAVRTGPASGVSVLVRRPQLPNGVAPELLGDMNWKSLGGHFMEVHWSKMPGRTFVQRIFLLLAIEMY
Length635
PositionHead
OrganismStylophora pistillata (Smooth cauliflower coral)
KingdomMetazoa
LineageEukaryota> Metazoa> Cnidaria> Anthozoa> Hexacorallia> Scleractinia> Astrocoeniina> Pocilloporidae> Stylophora.
Aromaticity0.05
Grand average of hydropathy-0.356
Instability index42.96
Isoelectric point8.53
Molecular weight70281.41
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15410
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.93|      24|     116|     320|     345|       3
---------------------------------------------------------------------------
  320-  345 (41.85/36.79)	RA.EIFPG.....TDLCITysCRKNS..SEENSS
  433-  464 (34.08/22.23)	RAvEVIDGlksrlNDPCIT..CHWSSvgSDTNTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     164.95|      51|     402|     153|     203|       4
---------------------------------------------------------------------------
  153-  203 (89.39/62.28)	KERADHT....IRQLGSNA.....KDFHSELMMLRKRWRLKR.TGTSITGDLTYRSAGSQF
  549-  609 (75.57/51.47)	KERQGHVgglmIKSPNGNKvvavrTGPASGVSVLVRRPQLPNgVAPELLGDMNWKSLGGHF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.08|      21|     115|     403|     427|       5
---------------------------------------------------------------------------
  403-  427 (26.31/28.76)	LTtveVAPNLqSESLLETVLKISRH
  523-  543 (40.77/27.26)	LT...VANSL.AQSLGWHVIHCSRH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15410 with Med17 domain of Kingdom Metazoa
Unable to open file!