<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15405

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTASTPMLHGSDLDECCTNVFALTDLCGLKWRKYVFSVTCQANPLEDPVLKSFSAALSHDILCAWRRCPLTGCQSGGDPKSISGAKELWVFWFGDDPNLQGIVSAELKESCHGCWEDGLPHEPRSLLFKALHNLLERCLLSRKFVRLGKWFTKPCESSAVENASSHLSFSFSFFIHGESSVCTAVEIQQQQKIRHLTLEDIAVAGTKQEGLSVLLGPYGLSGFLTGQTSHMEEMVSAKLVEEWKKFYPLDYSSDWSEPASLCQDKGVPVAVMVVVEETQMWYPSMYVVVPYEKNAIVDGSVLPKTDAVTCSGPTSLTPPASPLDPNSTDVVTGPGNLPPASNLSSVGVIDKKKLTQSLVQEVWQEITVTKPAANKNISLSNISKSAPTFMKTDSSGDTTTPTGQWDFEEPFKRTSCSCTSSSNISRPKAPAQVRSSFGITRPIPSPSYPLPSPQQQQQQQQPTQQNQGNTKLKKEKKKPLVPFHHRQSLDKERPEVLKSPVGAMTKGLPTSNVSTSVTQKRHPEVAFPQNSRKYQTTSLVNTTGISGPKSHAISVKPEDKCLQPPASLLKVNSSIVSSKGIANNQAEMLMKVESNNFEDFVGYKDSTASEDTVNKCYSLPSEGGFIVPLLPSNPLDCRPLGELMVSKEVSTLSPLETTMWESSRRPSIDGGIDCVPSPAKRRRESSTGRSRSDSTGGGRLKGRRNSSQPSPATTPLSDPFTPQPEELDMELIPPPMKSPTQVKPPLNKPRRRSSATGGDSPSLPLPGELSKPPSRVKNRRQSSRKKQQEEKEHLSKEIEEIKPCPIVNEKGTFPSFSSSDDEHEPIARLPTNLMTEQDLAVTVNDLDQLFDTDEEDDECGQSKAKIDFGSNQVASFDPIMNINTPHTIMSTVGVTNQDLARMFPTPPSQETVTHSPPCSVGNDYISPGSVKTIMHNTVLSPESHLMHLPGVDVEREKQHSPMELGPVFEIPKCQEFPVSYSFETVVSLPGYQELPSVMQYSPSWLQASQKTWTFPEIKLESTAEVLSCDITVGAPSPAVRFSSTHPASVNSDVKHLTSAAMSPASPASSVSSFSMPMQFPKTFHGSGLVAKPLFQTPLPEANSLSKVLNMSDSSANYFSDKCYDSVSLCSCLTSPEGVQAKGTINKGRDSDYCVCGFGALEAVKFTAGTGLFPDDIHSTSAENVKTLKKVNNVPQSAIEVKKEGLVAHCVRRRASSAPVSSQVPFCLLEEIVSQCSSPFSCYNLKLQLMFKGHHGIVKHVSGAWSQNKGAENGILQKVPHPTAVGALNFLRQLMQDALQKSTSRKTWEQPNGTVVQGPLSWKQLHHLATKGNEETPHAQPIPSVTVGYGGDWMSLSPIALHFWEKLLLEPYSCQRDVAYIVVAPENELVLNNVKLFFKEFSAVYETCRLGQHVAITKVLRDGILRIGQKSLKLAKEPVDDWFSHQGCSSDAAKLKLYAQVFKHQLGPYLASLNLDRHLLESEKGEKSDEKGPSKFGSDVGVDSAPKPGSTSSGTPNSEQTPSVFGEDESEQNSEDPPTVVVYIVNPFSNSSREESFPSYVGLLRCIADILPDLTESNKKNVVFQVVPIQQILQVDTLNGSRDATLTFVTQLKCLAFSVFSRCRKSLQLNINAKSLTGFGPAARHEALLRQREVENAKVYAAPYVLCQPIPMPPSDSADENATSLQALTQNASVLYCGYCLSHDDNYLLAVCTDSVGELIESCVITVEPCLRPDGRPRKTPARTKALIKLWEFCQGVVATSLVPWRLVISKLGRIGPEELKDWKEILSRTSVVAGDQKFNDTCKACFSLKQKNRPAILGTSLTSLEPEPSISLYMARALPKVNVLFEGNSSTRVSVGAVPKPDVSRTYIAVMPVASLKCTMGNQSSSKMHALPETTTETVVTDTDILLAGVDDDENDQDPLRHLFPLLNSSPPHLSSPGHMLPSPLDSSPIEGTSLLTRPATLTASPGVSVPSPFQPISRLSPFQPLHSTPSPSTANVATLEVQEDGDDKLSVPYAQGYIISTVQTGKMPGTFWASSSHSETCDPVILKASLHIHNPDLMEGMNGFVTAWHPLATKSHCHVLRSILQTYDALSWLTVDPVNRDRRSCLPVHLYMLCQLHETLSLLLENQSS
Length2130
PositionMiddle
OrganismStylophora pistillata (Smooth cauliflower coral)
KingdomMetazoa
LineageEukaryota> Metazoa> Cnidaria> Anthozoa> Hexacorallia> Scleractinia> Astrocoeniina> Pocilloporidae> Stylophora.
Aromaticity0.06
Grand average of hydropathy-0.346
Instability index57.26
Isoelectric point6.24
Molecular weight232598.30
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15405
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     116.24|      25|      28|    1926|    1950|       1
---------------------------------------------------------------------------
  750-  773 (33.43/ 9.85)	RRRSSATGGD.SPSLPLPGELSKPP.
 1926- 1950 (47.82/17.21)	LLNSSPPHLS.SPGHMLPSPLDSSPI
 1955- 1977 (34.99/10.64)	LL.TRPATLTaSPGVSVPSPF..QPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     546.82|     198|     677|     248|     454|       2
---------------------------------------------------------------------------
  248-  360 (145.13/61.56)	.........................................................................................................................................................................................................................................................................................................................................................................................PLDYSsdWSEPASLCQD.....KGVPVAVMVV....VEETQ.MW.YPSmyVVVP.....YEKNAIV...D..GSVLPKTDAVTCSGPTS..LTPPASPLDPNSTDV..VTGPGNLP..PASNLSSVGVIDKKKLTQSLVQ
  363-  453 (106.85/43.41)	WQEITVTKPAANKNISLSniSKSAPTFMKTDSSGDTTTPTGQWDFEEPFKRTSCSCTSSSNIS.RPK.........APAQVR..SSFGITR.................PIPSPSYPLPSP.............................................................................................................................................................................................................................................................................................................................................................................................................
  475-  602 (143.04/53.14)	............................................................EKK.KPL.........VPFHHR..QSLDKER.................P.....EVLKSP..................................................................................................................................................................................................................................................................................vgamtKGLPTS.NVS....TSVTQ.KR.HPE..VAFPqnsrkYQTTSLV...NttGISGPKSHAISVK.PEDkcLQPPASLLKVNSS.I..VSSKG.....IANNQAEMLMKVESNNFEDFVG
  603-  719 (79.66/23.97)	YKDSTASEDTVNKCYSLP..SEGGFIVPLLPSNPLDCRPLGELMVSKEVSTLSPLETTMWESSrRPSidggidcvpSPAKRRreSSTGRSRsdstgggrlkgrrnssqPSPATT.PLSDP.............................................................................................................................................................................................................................................................................................................................................................................................................
  977- 1075 (72.14/22.81)	........................................................................................................................ftpqpeeldmelipppmksptqvkpplnkprrrssatggdspslplpgelskppsrvknrrqssrkkqqeekehlskeieeikpcpivnekgtfpsfsssddehepiarlptnlmteqdlavtvndldqlfdtdeeddecgqskakidfgsnqvasfdpimnintphtimstvgvtnqdlarmfptppsqetvthsppcsvgndyispgsvktimhntvlspeshlmhlpgvdverekqhspmelgpvfeipkcqefPVSYS..FETVVSLPGY.....QELP.SVMQYspswLQASQkTWtFPE....IK.....LESTAEVlscD..ITVGAPSPAVRFSS......THPAS...VNS.DVkhLTSAAMSPasPASSVSSFSM............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.66|      28|      32|    1279|    1310|       3
---------------------------------------------------------------------------
 1281- 1310 (41.77/34.93)	PTAV.GALNFlRQLMQDAlQKSTSRKTWEQP
 1312- 1340 (47.89/23.65)	GTVVqGPLSW.KQLHHLA.TKGNEETPHAQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.94|      21|      32|      31|      56|       4
---------------------------------------------------------------------------
   31-   56 (28.80/30.59)	WRKYVFSvTCQANPleDPvlKSFSAA
   65-   85 (44.15/25.74)	WRRCPLT.GCQSGG..DP..KSISGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.53|      26|      33|    1640|    1667|       6
---------------------------------------------------------------------------
 1640- 1665 (44.07/36.30)	P..AARHEALLRQREVENAKVYAAPYVL
 1673- 1700 (41.46/25.00)	PsdSADENATSLQALTQNASVLYCGYCL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.08|      16|      33|     906|     927|       7
---------------------------------------------------------------------------
  906-  923 (27.07/13.02)	PPSQetVTHSPPCSVGND
  941-  956 (29.01/11.75)	PESH..LMHLPGVDVERE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.19|      21|      33|    1712|    1732|       8
---------------------------------------------------------------------------
 1712- 1732 (37.40/21.63)	TDSVGELIESCVITVEPCLRP
 1743- 1763 (36.79/21.15)	TKALIKLWEFCQGVVATSLVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.87|      16|      33|     807|     822|       9
---------------------------------------------------------------------------
  807-  822 (27.71/16.57)	VNEKGTFPSFSSSDDE
  843-  858 (25.16/14.29)	VNDLDQLFDTDEEDDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.60|      17|      23|    1121|    1143|      10
---------------------------------------------------------------------------
 1121- 1138 (29.39/30.55)	KCYDSvSLCSC.LTSPEGV
 1146- 1163 (28.22/10.94)	KGRDS.DYCVCgFGALEAV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.69|      19|      24|    1222|    1240|      13
---------------------------------------------------------------------------
 1222- 1240 (34.30/20.12)	QVPFCLLEEIVSQCSSPFS
 1247- 1265 (35.38/21.00)	QLMFKGHHGIVKHVSGAWS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.33|      24|      26|    1484|    1507|      14
---------------------------------------------------------------------------
 1484- 1507 (42.83/21.45)	GEKSDEKGPSKFGSDVGVDSAPKP
 1513- 1536 (43.51/21.91)	GTPNSEQTPSVFGEDESEQNSEDP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15405 with Med13 domain of Kingdom Metazoa
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