<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15404

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSAQLGREKSRSLKSAVLSGSFDRKMRAETLNARENARLEKQQRDIDLFKNNTEKVHTAEKNKVQSRMQSLRKTVLSRTQSNESSSSSTASSKMDGECVRFPRLPNSTDTNSKLSIEICTENIRTAPELHLVSEVNGQILTHLPSIMDTNSPGGRRRTLVKENNDSLNIFAGRRRSRTQSHGVVEDLKLPSNRIALKSTVQDCYGTPLASRRGLKALKELVNSYEEELGLKGKEFDGTKIHAFGSLNFYLEHSKFNDLLNSIRSKCKSCASWPDPAKAIRASLERQQQIENLAPVKNYISECLDKFQNAMKDKSIKVVAQRLEAITRKVGLKFIESGRECFINSDMFYVEVRMAADGTVSEVKVAHTGDPESCPELTRVLREGDYDEFLCHLQGLCDLYQLSRDTFQKPKILAALKAVETDINTIAAFYGTDVTSTEAITQCPVGFVTPRQGGRRMRLCYFASPYELVDVNRPGQDRYFTREEPPPRDFGYQVYVSLEQSQNTSLPISPLITEPVGYSILGLDPSIKYQVLNDNNSEEFQASFVLEFCKPLPAAVEIVQKIHEVIDKTGSFAHSSTVPIDSLIIREWLKDRGVSSTDHGNNYYASLPQHYHVYHVTENQSTAEELVQPSGMEPDSEDYLFELRSSEPFTLTVTFEHPCTSSMASIDFFVSEDDMVKATLTTVPGKPLFCSNDYISRVTQRCLSIPAAMRCIIRKAQSVKLEELPVKASEELLLPVGGGQPSTKLASLSLPPSAALFGATVGTPSNPNTPVFLGTSPSFSGFTLETPSPTLSAFTFSSISPTFSFNTTDITAATADSVTTTAVKQPEKKPEAAKTPTLPNLKITLKRKRADEYVIQNFQVPEEVPKSAEKTPVGQTASKSKETPDAESMDGDNFPFDLAAVSAANFTMGTTFPDVTAGLDGSVVVAAGTSAAGQHVGLTGADSLAAASGLGIVPTEIEGLSATADLFDIGAAGADATDLEGILQNLSGASHLPPGIVSGAAALDFDTGLGTGVTGLDVSDPGFDIDAALDASAAVDPSIAGTAGAFDVDSSLDFDLDNITGVGGLPPEVAGAAELLAVSGLGGSDGSVDIDMPGTSHSKI
Length1099
PositionMiddle
OrganismStylophora pistillata (Smooth cauliflower coral)
KingdomMetazoa
LineageEukaryota> Metazoa> Cnidaria> Anthozoa> Hexacorallia> Scleractinia> Astrocoeniina> Pocilloporidae> Stylophora.
Aromaticity0.06
Grand average of hydropathy-0.280
Instability index45.58
Isoelectric point5.14
Molecular weight118589.90
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364059

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15404
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      76.73|      22|      34|     814|     835|       1
---------------------------------------------------------------------------
  814-  832 (25.93/12.31)	................ADSVTTTAVKQPEKKPEAA
  833-  867 (28.13/13.93)	KTPtlpnlkitlkrkrADEYVIQNFQVPEEVPKSA
  869-  884 (22.67/ 9.90)	KTP................VGQTASKSKE.TPD..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.43|      13|      16|     917|     932|       2
---------------------------------------------------------------------------
  917-  932 (16.76/14.75)	GLDGSVVVAAgtsAAG
  936-  948 (21.67/10.38)	GLTGADSLAA...ASG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.21|      13|      16|    1019|    1031|       3
---------------------------------------------------------------------------
  992- 1011 (16.66/ 6.80)	PPGivsgaaaLDFDTGLGTG
 1019- 1031 (24.55/13.96)	DPG.......FDIDAALDAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.52|      35|      36|     734|     768|       4
---------------------------------------------------------------------------
  734-  768 (63.96/33.33)	PV.GGGQPSTKLASLSLP.P..SAALFGATVGTPSNPNT
  769-  807 (51.57/25.50)	PVfLGTSPSFSGFTLETPsPtlSAFTFSSISPTFSFNTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.08|      25|      35|     262|     296|       5
---------------------------------------------------------------------------
  262-  289 (36.04/52.17)	IrSKC..KSCASWPDpaKAIRASLERQQQI
  299-  325 (37.04/20.40)	I.SECldKFQNAMKD..KSIKVVAQRLEAI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.42|      32|     246|     363|     459|       7
---------------------------------------------------------------------------
  366-  400 (54.49/120.37)	HTGDPEscpELTRVLREGDYDEFLCHLQGLCDL.YQ
  460-  492 (56.93/ 9.26)	YFASPY...ELVDVNRPGQDRYFTREEPPPRDFgYQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.16|       9|      16|     890|     899|      11
---------------------------------------------------------------------------
  890-  899 (13.47/10.08)	GDNFPfDLAA
  908-  916 (17.69/ 7.91)	GTTFP.DVTA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.05|      10|      16|    1054|    1063|      13
---------------------------------------------------------------------------
 1054- 1063 (18.25/ 9.88)	DLDNITGVGG
 1073- 1082 (16.79/ 8.51)	ELLAVSGLGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      83.21|      19|      38|      92|     110|      15
---------------------------------------------------------------------------
   92-  110 (36.01/19.68)	SKMDGE.CVRFPRLPNSTDT
  112-  127 (19.54/ 7.76)	SKLSIEiCTENIR....TAP
  133-  149 (27.65/13.63)	SEVNGQ.I..LTHLPSIMDT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.86|      23|     156|     542|     564|      16
---------------------------------------------------------------------------
  542-  564 (40.52/30.39)	SFVLEFCKPLPAAVE.IVQKIHEV
  695-  718 (35.34/25.48)	SRVTQRCLSIPAAMRcIIRKAQSV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15404 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MSAQLGREKSRSLKSAVLSGSFDRKMRAETLNARENARLEKQQRDIDLFKNNTEKVHTAEKNKVQSRMQSLRKTVLSRTQSNESSSSSTASSKMDGECVRFPRLPN
2) QNFQVPEEVPKSAEKTPVGQTASKSKETPDAESMDGDNF
1
855
106
893










Molecular Recognition Features






MoRF SequenceStartStop




1) YLFELR
638
643