<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15396

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMALASNNGDGSVNGAPEPSSARPPSRMNDLPDEIIHITQGFIPLSLLLTRLAQTSHNALQEKIAELAKMPLPAASVNGNATAALDDTSTENLRKKGALASFAQDLHGKWLKALVITEWSRKSEMVSKLIDLKFHIDQQRILYDACLDNVVNVKRDLTFARMPSPDLKTALQILSSGSAPWMPDLNYIEPPRLTPREQLKWINDLNTLLSLRLNLDDYDKIPPQFKNYDIASGRVTFNVDGEFQVDLTIADEDFEKQFWFIDFRYDFRPAPSSLSPSLRSYLEGCVNEALSKDGLVGCYRCLHEFVLTFKINELKRQAIKLSRSSWTGTLSVEPLNRALAIQYWTSRAATTGTKSWILLAVNSGRKPDGSIDDRATSFIVAKWYRDGKEMKDIDIDLDLKRLSAESLLTDVIGRHIEYILTSVHDKLLTAARYKDRDAGMVLDVSRSDPATSSLSIQVGFRGKTALMVEPMTGVFALKPQSKFTVQYEHQLNNGRNLADDGAACLENVRCSVMEDEINRRGSLMGWTARKPPLTMEETKSATKLRAWTRVLWLQKDGWGASWFMAVFLGLGSDEWWLLEVNRTEAGRSVKYKGKLPLPKGHADLSEELWNNLSIFTTGMITQSIDVRELHRQKIKSRSSDSTDLSLSQPVRLPSIEIPLSAVFPSMVSGGKAKDESAREGDLSADNIDLFSLMQKYTGAALTLRRAWADDMLLLNFSGIQCMPRTGADGSPANELICLSDAVMRVRKPSRFAGLKGLVDRGVVYNPRRGEFSLQIRRRMGEPILDALKSRIKAVDRFVNLFEALANAGGAVSTELMTLGRVTFCYGNTADEEDEQGNETRRLSLDLSKDEMEVELGSGNPHLRAMDLMRRLVNSDGGIGALMAWLPASLPALRAVAELESNWDELEADKRGRVEFAMKSMAWMSIGYEIANKRVTLELRMRRRRDEAWWHMWRSDASTDDEFDEALKPIWTGHGDGWQGLTTGAVGRPEGGVGVMLLAADEAIRGRVVEPSRHVVVLD
Length1017
PositionTail
OrganismOphiocordyceps unilateralis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Ophiocordyceps.
Aromaticity0.07
Grand average of hydropathy-0.313
Instability index41.55
Isoelectric point6.18
Molecular weight113562.30
Publications
PubMed=26285697
PubMed=28970504

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP15396
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.84|      19|     263|     325|     351|       1
---------------------------------------------------------------------------
  326-  344 (32.17/33.35)	TGTLSVEPLNRALAIQYWT
  529-  547 (30.67/ 8.54)	KPPLTMEETKSATKLRAWT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     117.22|      41|     357|     572|     619|       2
---------------------------------------------------------------------------
  572-  594 (29.46/11.23)	.............................................................................................................................................................................................................................................................................................................................................................DE.WWLLEVNRTEAGRSVKYKGKL
  595-  619 (13.04/17.65)	PLPKGHADlseeLWNNLsifTTGMI............................................................................................................................................................................................................................................................................................................................................................
  944-  965 (23.57/ 7.12)	.........................tqsidvrelhrqkiksrssdstdlslsqpvrlpsieiplsavfpsmvsggkakdesaregdlsadnidlfslmqkytgaaltlrrawaddmlllnfsgiqcmprtgadgspaneliclsdavmrvrkpsrfaglkglvdrgvvynprrgefslqirrrmgepildalksrikavdrfvnlfealanaggavstelmtlgrvtfcygntadeedeqgnetrrlsldlskdemevelgsgnphlramdlmrrlvnsdggigalmawlpaslpalravaelesnwdeleadkrgrvefamksmawmsigyeiankrvtlelrmrrrrDEaWW..HMWRSDASTDDEFDEAL
  967- 1008 (51.15/28.32)	PIWTGHGD....GWQGL...TTGAV..............................................................................................................................................................................................................................................................................................................................grpeggVG.VMLLAADEAIRGRVVE.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.82|      14|     312|     310|     324|       4
---------------------------------------------------------------------------
  310-  324 (20.80/20.96)	INELKRQAIKlSRSS
  625-  638 (26.02/20.20)	VRELHRQKIK.SRSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     363.82|     108|     162|     668|     777|       6
---------------------------------------------------------------------------
  419-  460 (30.64/13.58)	..........................................................................LTSVHDKLLTaARYKDR..DAGMVLDVSRS...D..PATSSLSIQVGFR
  668-  777 (178.14/132.32)	GGKAKDESAREGDLSADNIDLF.SLMQKYTGAALTLRRAWadDML..LLNFSG.....IQCMPRTGADGSPANELICLSDAVMR.VRKPSR..FAGLKGLVDRGVVYN..PRRGEFSLQIRRR
  825-  942 (155.04/108.51)	GNTADEEDEQGNETRRLSLDLSkDEMEVELGSGNPHLRAM..DLMrrLVNSDGgigalMAWLPASLPALRAVAELESNWDE.LE.ADKRGRveFA.MKSMAWMSIGYEiaNKRVTLELRMRRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.50|      13|      19|     180|     192|       7
---------------------------------------------------------------------------
  180-  192 (27.87/18.77)	WMPDLNYIEPPRL
  200-  212 (23.63/14.75)	WINDLNTLLSLRL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15396 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MALASNNGDGSVNGAPEPSSARPPSRMNDL
1
30










Molecular Recognition Features






MoRF SequenceStartStop




NANANA