<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15393

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDTADYDTNTVLISNIASISFRIYESPLDTSHSFAATALDVENTLRRDGHLVVYDSARRGLWHFQILAQDEVNSHNVNATLDLCGHELVLVEEGLLEPASLQKWRSQQQQQPVQTPTSSRSSSSALDQAQRNGLFNLAPPGTLSTSQDQEAKMADPGIEPKPATSPHRAVYENFITALLLSISCTFCVRTGAVPLNYRTMLLVSETLEVGNPLDSCPQQCQIVATLKAYVTTTGVLVVSFALSRCRGLSSLAELVSSNLPRSGTSILAAPFGVVSNNQLSPMGDLGTVSLAQTPNTQALSLRVVHNRGDSLWKQACLKILKLRGIMSSAVADCAWVNLSVPKPRLQDAKSEAKRQQPSTATITIPWPGPLCFRKKMVNLPCMSLVGDTLRSGFEESHDPLSNARTWFNSAADRDQKASRRKADRNFALKEAQALDARPPKPSSPSPAAVRRPSAAAGGTIYPTPPDGIQHHNGVTPSMDGTLSSPGNTLSAAPANDADQGAFHASAVSDPIDIGDESKRQRSDHNLLGEADDTFGEMGGDMFGDHDITEADFSFFDEQPGGMDLDVAMADMGAATLPVVGVQEAPEAASQDKVTAQPERDDVVFAKPELKHARSSCNDAPSQRGRDNRLGPTKREASPFDPHTVFKRLRASLSTTARHHGFDTLRLDTSTIPQINRKYEQGGQFDYTKMANLEKPRLQQGALPETDYLKRHGKQGKRPKNGPFSAETFMKGLMGLESTGLQASPGRIESDDDDSSAGSDDDESCYSVEEPMSPVKSSIKLMPADDDVASQVTSLRDVESMEEPDQQLAVELPRLSKPESPELPLSLLFLDPEPLSLDLCLTDEDLIQVAQLLTDQAATGLLDIVSGQNGIAVLPATTLDSSTLTACSRNAVQVLREIVPSFLRGAAAVNLKGFLDIPDVPLLGQPTRVQPRPVPGRDHNAEPLRPSNLYQIPGPHLEVRRSEMKLSVLPSAVLFWESLGLAPSSGGKDVSAVCVFPGWTGMTDNVKAFLGCLKSVYEMLKLGSFESLALPAGLEAGALAYEVDRISTSPGPAMTGHGSALAQSMDTLLGALSSSEATAFNVVVYFIYWPSTPATIIEACIAFQRLSESYRKTGGQKDVVLQLVSANLISSPTAVVVTPAPELVKISMETYDRVSGNVMPAPAIRLEQPLPRIIDFKLTVSPSASLIRENSCIHIAYAQSVDDRWITAAWTDDRGNQQETASYCLGRRGRPASRSMNEVAHDMWELTLELISVWKVHWRVVITKCSPMDQHEIDFWAELARTEMKASVTMVLMTVDTNPSLQLLPPPVKLPYTTPVSTPPAAATATVSPEQTTDTTETESEAVLSDVTDQTWGAVVGHRLNVSLSVVDVHAALASGYLIKRTGSRLEDAPVLMEVNLVHTDASPRAYEPLLREMLSYFRGLGTLARARGVVQRETDVRPWHIAAAEKGVRALYLLM
Length1455
PositionKinase
OrganismOphiocordyceps unilateralis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Ophiocordyceps.
Aromaticity0.05
Grand average of hydropathy-0.240
Instability index49.41
Isoelectric point5.26
Molecular weight157527.33
Publications
PubMed=26285697
PubMed=28970504

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP15393
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     755.80|     255|     272|     301|     570|       1
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  301-  522 (328.11/188.98)	........................................................LRVV.................HNRG....................................DSLWKQACLK..ILKLRGIMSSAVADCAWVN....LSVPK.PRLQDAKSEAKRQQPStatitiPWPGPLCFRKKMVNLPCMS.LVG.DTLRsgFEESHDPLSNARTWFNSAADRDQKASRRKAD.RNFALKEAQALDARPPKPSSPSPAAVRRPSAAAGgtIYPTPPDGIQHHNGVTPSMDGTLSSPGNTLSAAPANDADQGAFHASAVSDPIDiGDESKRQRS
  523-  793 (371.10/201.61)	DHNLLGEADDTFG.EMggDMFGDHDITEADFS..FFDEQPggMDLDVAMADmgaatLPVVgvqeapeaasqdkvtaqPERD....................................DVVFAKPELK...........HARSSC...N.....DAPS.QRGRDNRLGPTKREAS......PFDPHTVFKRLRASLSTTArHHGfDTLR..LDTSTIPQINRKYEQGGQFDYTKMANLEKPRlQQGALPETDYLKRHGKQGKRPKNGPFSAETFMKG..LMGLESTGLQASPGRIESDDDDSSAGSDDDESCYSVEEPMSPVKSSIKLMPAD.DDVASQVTS
  796-  935 (56.59/21.42)	DVESMEEPDQQLAvEL..PRLSKPESPELPLSllFLDPEP..LSLDLCLTD..............................edliqvaqlltdqaatglldivsgqngiavlpattlDSSTLTACSRnaVQVLREIVPSFLRGAAAVNlkgfLDIPDvPLL....GQPTRVQPR......PVPG.............................................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     295.63|     100|     106|     982|    1087|       2
---------------------------------------------------------------------------
  982- 1033 (40.31/37.87)	..........................................................PSSGGKDVSAvCVfpGWTGMTDNVKAFLG.CLKSVyeMLKLGSFESLALPAGL
 1034- 1134 (150.95/104.81)	EAGALAYEV.DRISTS..PGPAMTGHgSALAQSMDTLLGALSSSEATAFNVVVYFIYwPSTPATIIEA.CI..AFQRLSESYRK.TG.GQKDV..VLQLVSANLISSPTAV
 1141- 1224 (104.38/65.93)	ELVKISMETyDRVSGNvmPAPAIRLE.QPLPRIIDFKLTVSPSASLIRENSCIHIAYaQSVDDRWITA.....AWTDDRGNQQETASyCL.....................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.77|      11|    1197|     242|     252|       4
---------------------------------------------------------------------------
  242-  252 (20.79/13.28)	LSRCRGLSSLA
 1414- 1424 (20.98/13.47)	LSYFRGLGTLA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15393 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ARHHGFDTLRLDTSTIPQINRKYEQGGQFDYTKMANLEKPRLQQGALPETDYLKRHGKQGKRPKNGPFSAETFMKGLMGLESTGLQASPGRIESDDDDSSAGSDDDESCYSVEEPMSPVKSSIKLMPA
2) GAATLPVVGVQEAPEAASQDKVTAQPERDDVVFAKPELKHARSSCNDAPSQRGRDNRLGPTKREASPFDPHTVFKRLRASL
3) LSNARTWFNSAADRDQKASRRKADRNFALKEAQALDARPPKPSSPSPAAVRRPSAAAGGTIYPTPPDGIQHHNGVTPSMDGTLSSPGNTLSAAPANDADQGAFHASAVSDPIDIGDESKRQRSDHNLLGEADDTFGEMGGDMFG
4) YTTPVSTPPAAATATVSPEQTTDTTETESEAVL
656
572
400
1311
783
652
543
1343










Molecular Recognition Features






MoRF SequenceStartStop




1) HDITEADFSFFD
2) LKEAQAL
3) TDYLKRHGK
545
428
705
556
434
713