<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15391

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMDGNDESKTALPFRLARLRRAPSSANLRRRFLLEAAAAQQRDAADDDAGGNRQPRFWRISAWVEEFMFYHVIKILVEGSAFRDIRSALVLVKVLCRWMNLFTAASAAFATNVLAQVQYSQARDDMEVSRAAFLPLLLRLVETPALVEAMSHPFAKDVRKDLSQSLTGFMHTLQPAPGFIERLDMFRSETLARLDPPFKKKQADASTAMDELLEPALRLDNFVVPDMPISNSRAGLYVYLNAALVGRPLIDDVLLLAFLHNRYQGETQSGAIDLILASFDILANTVFRNEGPKDAHLLRSFLINKLPLLLCQLFASQFSTASSEFCITEALNQVDTSVFPTASLMFDESRSNNPYTESVREEFCTACALHGLVQREHVERILGETSMSYEPSLEKYSKDKLVQSCLSDPDKIQGLVRDIDKMDGNAGAVCQALVELMRQLCVSKETMSLKLLCVQLAHKPQSLDIVLLFERLPTVLEPLCQLLDNWRYDDDQGEYQPIYEEFGAILLLVLAYAYRYNLRAADIGIVSPDSCVGKILNRAHISRPLGDLTEQEKSHINGWIHGLFGSETGGLGDDLMSSCPPQDFYLLVASIFQYIVVAYTHGYLNDESLKSGIEYVVDTFLLPSLVPAIRFLADYLWVEQREQKSVIKILQLMLLPSSISGEASTMLFSVKNLIAKPLEYSLRSYQKQDPKNQDIEPLLRALRDSLPLSRRTGGAEHNELESWSSSSSSGLSGAVRHTVQGLVQMHHGLNVMPTSYTHRQMIAACRVVGTRRVLRAMLDEVRYQSVAGAASVVYDVVAALVCAPDVTIEPPATSSLLGNEARASQRRLTLREVLKSEAEGCHKLHNKDATLAEMVVRLHRRVEALLALPPAQALLQAPDMSLDLSGAPTGLGEAISAAVAQGGDGMVVDGVGLDLASSDLGLGGPSGGGLETTSDGDIFSGIDAGMDMFGGWDGMDTS
Length957
PositionTail
OrganismOphiocordyceps unilateralis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Ophiocordyceps.
Aromaticity0.07
Grand average of hydropathy-0.027
Instability index49.87
Isoelectric point5.25
Molecular weight105368.42
Publications
PubMed=26285697
PubMed=28970504

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15391
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.03|      29|      30|     882|     911|       1
---------------------------------------------------------------------------
  882-  910 (48.91/27.68)	DLSGAPTGLGEAISAAVAQGGDGMVVDGV
  913-  941 (50.12/24.02)	DLASSDLGLGGPSGGGLETTSDGDIFSGI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      84.07|      31|      35|     589|     623|       2
---------------------------------------------------------------------------
  582-  603 (15.19/16.62)	.............DFYLLVASIfQYIvvAYTHGYL
  604-  635 (47.05/36.96)	NDESLKSGIEyVVDTFLLPSLV.PAI..RFLADYL
  638-  656 (21.83/ 9.42)	EQREQKSVIK.ILQLMLLPS...............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     137.79|      34|      35|     122|     155|       3
---------------------------------------------------------------------------
   82-  106 (31.94/14.06)	...............RD....IRSA.LVLVKVLCRWMNLFTAA....SA
  107-  151 (46.74/23.59)	AFATnvlaqvqysqaRDDMEVSRAAFLPLLLRLVETPALVEAM....SH
  152-  188 (39.60/18.99)	PFAK.........dvRKDLSQSLTGFMHTLQ...PAPGFIERLdmfrSE
  196-  218 (19.50/ 6.04)	PFKK..........kQADASTAMDELLEPALRL................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.24|      34|     359|     368|     404|       4
---------------------------------------------------------------------------
  347-  383 (46.48/38.88)	ESRSNNPYTESV.REEFCTAC.....aLHGLVqREhVERILGE
  384-  424 (48.76/35.20)	TSMSYEPSLEKYsKDKLVQSClsdpdkIQGLV.RD.IDKMDGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.23|      13|      15|     753|     765|       5
---------------------------------------------------------------------------
  753-  765 (24.11/16.01)	TSYTHRQMIAACR
  769-  781 (21.12/13.17)	TRRVLRAMLDEVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.86|      12|      16|     703|     714|       6
---------------------------------------------------------------------------
  703-  714 (21.59/11.39)	DSLPLSRRTG..GA
  720-  733 (17.27/ 7.75)	ESWSSSSSSGlsGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.55|      14|     329|     463|     484|       7
---------------------------------------------------------------------------
  300-  313 (26.18/ 8.79)	FLINKLPLL...LCQLF
  466-  482 (20.37/16.62)	LLFERLPTVlepLCQLL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15391 with Med5 domain of Kingdom Fungi
Unable to open file!