<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15386

Description Uncharacterized protein
SequenceMTSRPPMGVPPRQPQRAPASNLAVQRPTHHQRSLSQQYLASSSSPAVRKDTHLDAPGESPDVPPPAAQGRHHASTPRRGSSKLRLELSTNNWDSDLAATTESPQILTPSRVAPVLAAPVPDAPGTDKVSPAQSRGSQHDDNPPIPMPKRRPQPPERPVPIPRPSTSAAAPAKKDARPKPYTVEVPSDAPRFVSIHKLDLPNRDPFSKGLHTGNADFFPWSGHHHEDEWSSEAIQKGTWDRGAQNETASARVAVLPALKQKSGLNALSTIFMGVMNQRRFRGQILSPSTFKPPPRVTLTDTKREVWLKDLANPTISLRRLSRTIPHGIRGRTLLDQCLNKNVPTERAVWLAKCVGANEIRAFKRKGAGGAFVMGGESKWVRDWTVFVEQFVEAVVSAFGEPDWKTRVTYAIRLATNLYSEHLLDRDHYLDWITSNLESSSQPKMPMWILIAQITWADLVRSRKYGRRLVYTLLTQLDNIHNDPDRDILIQLSSQLTSLLKTLLRSNPESFVAPSLWPRHRDGLKAFLASDDGVSQDAWQRVNGRNARLLVTNTASPPAGRQHLIKLLDSTIQDHNDGELAAKCLAVTDDRTELVKTLVEWATSVHRPGLAKIYVAVSLIKSWAASDATTSVIVDLLDDVSATDRLRKKAVFHLVSELIRARLFSVPRYIKWLIGRGGLHDAAEIDPDDGPCSSRLLVELPIHCLSESQRSQRTNVLWRAGQYSTADEAKDTANALRCVDSSLGLLQHLGNADGPTKCLSLPKLLRRVSHSSRAVQTSIGAHLRDVLTPDLLGKVEPVVALSTFSSARLVLETAQDFSCLSQVLKSYAAASDVEVLAACADTVNSLLDVFMAMGTADGLFGSLTGRLKSLKCEQAAGARPLLVALTGLARRLPHRSAVAQQLQRELAQSERSNALDACSPVSDSMALQAQNGESEVAEQIDKLLASGNTVDPPTMNRLFRNIIPKLEAGWTKADDGGRRVFASLLARLRIFDAQHFDKLMADWVSHIGTLKERPRLLGLFPLLISLGCLSMPILLQSANSVSSSADAGSSSDASAVYLQELLQLIVTKLPRAGCLDTVEAYRFEIRQKSARLEHSGALLSLIRNAVAEYAAVRSREPEVDCPLDEAACKDCLVETLRYLVVTDSSAVAKVLDVGTLAASAVELVDEMVTKLVAPGGGGDGGPQESFDQLLGLCNELTMPFCQLKLDVDLSGVGEPASRFEGFARAMDRAMEARNIVWTKMLPCLSQEITRNLSTQAHARFLGLIPSLQSAKASDDGSTEHVVHLAENLLGVMEAISSGQQPPPPPSWSQLTTTLVEKLCDLWEIVASRQEEAREEVLDRWLPALLRFIVLHSPCPEAATGTTQSVPATAHHEIRARIILVLCGLLLELDSRPRTARGGLSEHVLDVATLLVDALPDEVRTQCSRSILFLPGGASTASTSSDPRLYYLFSVQQPTWAENLKLAHKERASIAYSAAARGMSTLYGIGPASSERLSPYVLRRWEVLSEPTPNVGENDTSLSLGLFEAIRMQ
Length1526
PositionKinase
OrganismOphiocordyceps unilateralis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Ophiocordyceps.
Aromaticity0.05
Grand average of hydropathy-0.215
Instability index47.00
Isoelectric point8.08
Molecular weight166793.26
Publications
PubMed=26285697
PubMed=28970504

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15386
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     245.24|      67|      94|     413|     501|       1
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  413-  486 (104.66/75.26)	ATNLYSEHlldRDHYLDWITSNlESSSQPKMPMW.........I..LIA..QITWAdlvRSRKYGRRLVYTLLTQL...DNIHNDPDRDI
  511-  580 (93.65/67.12)	APSLWPRH...RDGLKAFLASD.DGVSQ...DAWqrvngrnarL..LVT..NTA......SPPAGRQHLIKLLDST...IQDHNDGELAA
  942-  995 (46.94/19.10)	..................LASG.NTVDPPTMNRL.........FrnIIPklEAGWT...KADDGGRRVFASLLARLrifDAQHFD.....
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     261.39|      66|     227|     777|     842|       2
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  672-  732 (64.05/38.04)	IGrGGLHDAaeIDPD...........DGPCSSRLLVELP..IHCLSESQRSqrtnvlwragqYSTADEA...K...............DTAN
  777-  842 (110.69/72.19)	IG.AHLRDV..LTPDLLGKVEPVVALSTFSSARLVLETAQDFSCLSQVLKS...........YAAASDV...EVL.........AACADTVN
 1005- 1077 (86.65/54.58)	IG.T.LKE....RPRLLGLFPLLISLGCLSMP.ILLQSANSVSS.SADAGS...........SSDASAVylqELLqlivtklprAGCLDTVE
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     207.15|      63|     119|    1135|    1201|       3
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 1135- 1201 (97.82/59.72)	RYLVVTDSSAVAKVLDVGTlAASAVELVDEMVTKLVAPGGGGDGGPQESFDQllgLCNELTMPFCQL
 1257- 1319 (109.33/56.87)	RFLGLIPSLQSAKASDDGS.TEHVVHLAENLLGVMEAISSGQQPPPPPSWSQ...LTTTLVEKLCDL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     292.94|      58|     227|       8|      65|       4
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    6-   63 (99.94/47.22)	PM...............................GVPPRQPQRAP...ASNLAVQRPTHHQRS....L.....SQQYLASSSSPAVRKDTHLDAPGESP........DVP
   64-  129 (70.54/31.20)	PP...............................AAQGRHHASTPrrgSSKLRLELSTNNWDS...dLaatteSPQILTPSRVAPVLAAPVPDAPG.TD........KVS
  130-  200 (64.72/28.04)	PA..................qsrgsqhddnppiPMPKRRPQ.PP...ERPVPIPRP................STSAAAPAKKDARPKPYTVEVPSDAPrfvsihklDLP
  203-  291 (57.74/24.23)	DPfskglhtgnadffpwsghhhedewsseaiqkGTWDRGAQNET...ASARVAVLPALKQKSglnaL.....STIFMGVMNQRRFR..GQILSP..ST........FKP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     140.26|      42|     112|    1214|    1255|       5
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 1214- 1255 (74.89/46.09)	ASR.FEGFARAMDRAMEA..RNIVWTKMLPCLSQEITRNLSTQAH
 1324- 1368 (65.36/39.25)	ASRqEEAREEVLDRWLPAllRFIVLHSPCPEAATGTTQSVPATAH
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.12|      29|     535|     206|     234|       6
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  206-  234 (58.20/34.29)	SKGL..HTGNAD....FFPWSGHHHEDEWSSEAIQ
  740-  774 (40.92/21.88)	SLGLlqHLGNADgptkCLSLPKLLRRVSHSSRAVQ
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.62|      22|     495|     876|     898|      11
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  876-  898 (33.62/25.56)	ARPLLVaLTGLARRLPHRSAVAQ
 1373- 1394 (38.00/24.24)	ARIILV.LCGLLLELDSRPRTAR
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15386 with Med12 domain of Kingdom Fungi
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