<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15385

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMSAGDGSLLLSLKPVPVAEKEAKNVAEFISRVNGQPGGFRDLTEKDLIEKSRDETNGDGDGSQDVEMVDAEDEEDGSKDGALARLEVLKNVEYAGNTAMLILDSLSLLLSKQNPTQASLTLSQQLRDMVGIGTLGADRLDEPTINQERVKDAEQVATGWTLMEVNKTRDAAVEAASLLEKEVDIESRYWDDVMAVKKAGWSMCRVPNERHTLAVRFGFSETASPEFKNNGLAPMRRGEDGSVELDLGRLGGVSECLVVTYLRNGQVAGRSVPRCRGRANTDPTSLESRVLEARNTIFAKELWHELIKEARTLAAYDVRLQGSLLRCQIDDEAAMTIQLLSLASCPSPDDSLPDNSMAEAISLGLHILLSYAHRHNELMRTRPMPPHVSRSRPTNQTYALLRPVIARLASEASIDSCTRLVGRLSKALTRAGLGSSFTPRLPPAPSTTPESSSRHVSASQTLVRNLLQPREFSIDFSILPDLTLTIRGRTFLFPVTSTLFNVTIPPASPLRLSCPPYPDGYSDVTALTEYLYTSVARALNCHFLNRLLTSGNNANNDNNNSSSTRRWTQSVVGTSIRDGESEHCSLHFSIHDEDAITSLVLSSTVVAVPNDDDPPLRRSWKWCSSPAPSESESRPLADVVVDAAELSPS
Length648
PositionHead
OrganismOphiocordyceps unilateralis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Ophiocordyceps.
Aromaticity0.05
Grand average of hydropathy-0.337
Instability index50.82
Isoelectric point5.20
Molecular weight70792.77
Publications
PubMed=26285697
PubMed=28970504

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15385
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      61.94|      17|      17|     199|     215|       1
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  158-  170 (15.08/ 6.41)	......GWTLMEVNKTRDA
  193-  211 (24.17/14.80)	MAVkKaGWSMCRVPNERHT
  212-  229 (22.69/13.43)	LAV.RfGFSETASPEFKNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     323.23|     109|     168|     231|     353|       3
---------------------------------------------------------------------------
  231-  353 (157.89/130.17)	LAPM..RRGEDGSVElDLGRL.GGVSECLVvtylRNGqVaGRS.VPRCRGRANTDPTSlESRVLEARNTIFAKELW.HELIKEARTLAAYDVRLQG.........SLLRCQIDDEAAmtiqlLSLaSCPSPDDSLPD
  400-  522 (165.35/98.05)	LRPViaRLASEASID.SCTRLvGRLSKALT....RAG.L.GSSfTPRLPPAPSTTPES.SSRHVSASQTLVRNLLQpREFSIDFSILPDLTLTIRGrtflfpvtsTLFNVTIPPASP.....LRL.SCPPYPDGYSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.38|      17|      18|      44|      61|       4
---------------------------------------------------------------------------
   44-   61 (25.53/17.82)	EK.DLIEkSRDETNGDGDG
   63-   80 (23.85/11.90)	QDvEMVD.AEDEEDGSKDG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15385 with Med17 domain of Kingdom Fungi
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