<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15368
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MASHLSTKDRLLALIDDIELISKEMIEVSIAPKPQKLSAADHAQLTDLLLSKDSELKKTLGLADEQAKIQQKMNDLKAEVENKDQDIFHLQRQLKDAEQILATSLYQARQKLASIVKSRKRPVPSEELIKFAHRISASNAVSAPLSWQPGDPRRPYPTDLEMRLGMLGRLCDLPLNGHTPSTLNELHRMTTGGVPASATNQFTWHPTGELHMSVGGGNSVAIDGRGKDAPNQEDVEVMSTDSSSSSSSDSQ |
Length | 251 |
Position | Middle |
Organism | Heliothis virescens (Tobacco budworm moth) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota>
Neoptera> Endopterygota> Lepidoptera> Glossata> Ditrysia> Noctuoidea>
Noctuidae> Heliothinae> Heliothis.
|
Aromaticity | 0.03 |
Grand average of hydropathy | -0.538 |
Instability index | 46.58 |
Isoelectric point | 5.91 |
Molecular weight | 27509.77 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP15368
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 64.65| 17| 22| 176| 193| 1
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176- 193 (28.93/24.79) NGHTPSTLNELHrMTTGG
200- 216 (35.72/25.25) NQFTWHPTGELH.MSVGG
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