Description | Mediator of RNA polymerase II transcription subunit 19 |
Sequence | MMSDQFRKVEPYSPKSSPRGARSPVVSRQDSSGTLKTTISLGKNPSIVHSGPFYLMKEPPGECELTGATNLMAYYGLEHSYSKFNGKKLKESLSSFLPNLPGILDGPGQEDNSTLGSVIAKRPIGGKELLPLTSAQLAGFRLHPGPLPEQYRYVSATPPKRHKTKHKKHKHKDGVPPGQETPLQDSSNPDTYEKKHKKQKRHDDDKERKKRKKEKKRKKQKHSPEHGGLTPSQHPIP |
Length | 237 |
Position | Head |
Organism | Heliothis virescens (Tobacco budworm moth) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Lepidoptera> Glossata> Ditrysia> Noctuoidea> Noctuidae> Heliothinae> Heliothis. |
Aromaticity | 0.05 |
Grand average of hydropathy | -1.180 |
Instability index | 58.36 |
Isoelectric point | 9.94 |
Molecular weight | 26463.84 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364151 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP15364 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 91.27| 26| 32| 144| 173| 1 --------------------------------------------------------------------------- 144- 173 (46.37/29.63) PG.PLPEQyryvSATPPKRHKTKHKKHKHKD 177- 203 (44.90/20.37) PGqETPLQ....DSSNPDTYEKKHKKQKRHD --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) KHKKQKRHDDDKERKKRKKEKKRKKQKHS 2) MMSDQFRKVEPYSPKS 3) QYRYVSAT | 195 1 150 | 223 16 157 |
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