<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15343

Description Mediator of RNA polymerase II transcription subunit 1 (Fragment)
SequenceMFYLEILVESSGSVKDVKIHHEGKIEQQSCEELVSCISRGDFADFTAQLEGLTAVYQLSAEKKVKCKAFSALQSLEEDLCTMRQLQSFIKDPWAQVHKSPIGFLQKRRGGHAMRLTYFVSPYELLDKDKGLTPLTAELLTVGKPTVTSGLASLVAPSHTPIGHSATVLLEGSTPNKLQLSPIISGGQRSGKGNGPVYAQLVPQNSAMLPACFTLKLSQPTPLCAGLAKLIHATTEVEVAGDWANAKPMLGLVAQHAYNKLTPGKVIELNLSKGLFVNLPEQTQCYFVCESRGLAGCVVSSVPFTHPSHVAPLLACLRQQALFNALLASCVRTQAKQFIELESVLMFEVSALSWQHISISLEHPGDESMATVELELSDPAAPRASLYTLHNANSDHINEYITRVLQKTHSIPITLRSLIKIWEREAASKQLNGGYSALEPNFSCGLGGLDPGGDQIKHEPGSMHSRALYPSSVNHPHQGGAYLSEQQHHLSAMCQDSMSDTKPPTEERKSKKRKSDDVWSSSQKKGKQGITEMMDSDSDSDNSDEYVNEDENTINSNSTNDDMEGRESSVSQNEFTSDMELSAMDATDALGGQDNRTSSDMDNSNDGDVDDIIRNSFQKSDHK
Length622
PositionMiddle
OrganismHeliothis virescens (Tobacco budworm moth)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Lepidoptera> Glossata> Ditrysia> Noctuoidea> Noctuidae> Heliothinae> Heliothis.
Aromaticity0.06
Grand average of hydropathy-0.395
Instability index46.87
Isoelectric point5.45
Molecular weight67878.57
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364059

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15343
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     194.82|      53|     141|      98|     167|       1
---------------------------------------------------------------------------
  111-  167 (85.16/75.66)	HAM.RLTyfvsPYEL..LDKDKGL...TPLTAELLTVGKPTVTSGLASLVAPSHTPIGHSATV
  220-  253 (37.51/13.63)	...........................TPLCAGLAKLIHATTEVEVAGDWANAKPMLGLVA..
  255-  309 (72.16/35.06)	HAYnKLT....PGKVieLNLSKGLfvnLPEQTQCYFVCE...SRGLAGCVVSS.VPFTHPSHV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.86|      27|      27|      10|      36|       2
---------------------------------------------------------------------------
   10-   36 (48.04/35.97)	SSGSVKDVKIHHEG..KIEQQSCEELVSC
   38-   66 (41.82/30.33)	SRGDFADFTAQLEGltAVYQLSAEKKVKC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.05|      39|      41|     537|     577|       3
---------------------------------------------------------------------------
  537-  577 (61.65/58.93)	SDSDNSDEYVNEDENTinSNSTNDDMEGRESSVSQNEF.TSD
  581-  620 (62.40/51.55)	SAMDATDALGGQDNRT..SSDMDNSNDGDVDDIIRNSFqKSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     148.74|      50|      83|     349|     408|       4
---------------------------------------------------------------------------
  349-  408 (68.38/46.89)	SALSwQHISISL..EHPGDESMAtvelelSDPAAPRA.SLYTlHNANSDHI.NEYITRvlQKTH
  435-  488 (80.37/34.22)	SALE.PNFSCGLggLDPGGDQIK......HEPGSMHSrALYP.SSVNHPHQgGAYLSE..QQHH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15343 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LGGLDPGGDQIKHEPGSMHSRALYPSSVNHPHQGGAYLSEQQHHLSAMCQDSMSDTKPPTEERKSKKRKSDDVWSSSQKKGKQGITEMMDSDSDSDNSDEYVNEDENTINSNSTNDDMEGRESSVSQNEFTSDMELSAMDATDALGGQDNRTSSDMDNSNDGDVDDIIRNSFQKSDHK
445
622










Molecular Recognition Features






MoRF SequenceStartStop




1) DGDVDDIIRNSFQKSDHK
2) SQNEFTSDMELSAMDATDALGGQDNRTSSDM
605
570
622
600