<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15342

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMTDSNAVVMASANGLIDKSKELQKEILMEKLRSKTSQFKNLTETSKGVRMALLDKRWGIDSADRMILKKCLDSLQHCIKVSSLQSLIERLECLSRQLGLKFVVGTSGVNLFISSDMFYLEILVESSGSVKDVKIHHEGKIEQQSCEELVSCISRGDFADFTAQLEGLTAVYQLSAEKKVTYASIPVTGEVRRVKCKAFSALQSLEEDLCTMRQLQSFIKDPWAQVHKSPIGFLQKRRGGHAMRLTYFVSPYELLDKDKGLTPLTAELLTVGKPTVTSGLASLVAPSHTPIGHSATVLLEGSTPNKLQLSPIISGGQRSGKGNGPVYAQLVPQNSAMLPACFTLKLSQPTPLCAGLAKLIHATTEVEVAGDWANAKPMLGLVAQHAYNKLTPGKVIELNLSKGLFVNLPEQTQCYFVCESRGLAGCVVSSVPFTHPSHVAPLLACLRQQALFNALLASCVRTQAKQFIELESVLMFEVSALSWQHISISLEHPGDESMATVELELSDPAAPRASLYTLHNANSDHINEYITRVLQKTHSIPITLRSLIKIWEREAASKQLNGGYSALEPNFSCGLGGLDPGGDQIKHEPGSMHSRALYPSSVNHPHQGGAYLSEQQHHLSAMCQDSMSDTKPQTEERKSKKRKSDDVWSSSQKKGKQGITEMMDSDSDSDNSDEYVNEDENTINSNSTNDDMEGRESSVSQNEFTSDMELSAMDATDALGGQDNRTSSDMDNSNDGDVDDIIRNSFHKSDHKRQKLKSKDSELRPSRSASSLLLDLTEGKSYMPSSVSITPIGSTSNTPNAGTGSSITSMLCLDRRPGIEIIPITAAAPAALPSSITITPITSSQMKTLDDRIRSEKKSSRSGEERSKEKKKKRRRDDSMGPPEKVPPKQDPLTKPVSVSIKPTDGSPLRATSPNSLIRKFSPSPTHGRSVSITKSPSPSTVKGMGKPSGTSSHHSSPRHSPVQNSPKHLSGYSSPKNHSISSPKHSSSGSGKPSMSALKSATSGSPSGKSGTTGYDLTKKLSKDSYGSSSMTSRDKEKKHSSLSFSSSDRSSPKLKNPIKLKQLEITPVSCDSPVTEPLISPPNIEVNKSNAPSQARNRKGSLSAVIDKLKSAQHCGTDSEISAKSSSSSSSTKFSDPKASTAGGSGKLSDSKNQEYMVKPSSDGMKITINKTRTKDSSSSSSKLNYSSSSSKQSSPQLTPPSQGSPKTHTGLKPGVISGPASKKTQAMQSSKSGSVTSGSTPPKANMSPSDSSGSGNSSMPKVPYSKSSSASSAGINLSKSGSKSSSGSPKSSSTDLAKIIRDREREKARTKLMTNSEKSIFSSKSERHSSPSGSRDEIDGERFKSSKEANFLVEGLIKPLDTSKFQIPKLKNQNTPDKNSPAAQYDQRSLVNDFARTLEQSKYQFPHFDNPGARTADSIQKSAYPLNVPKPLLNMGSMSPKTIPPGKNDQSERPLEFSKAMADSISKGESPVRVKDDSKDGFSASFPILPLDFKTEMAKGFAAPKGSLEDRKGADSCMKPPASGAVARSGATTPQEAAEMLLDFSSSSGSKVSGMVAVRPVYPSSPALALQLAKSPAPSPLVAPSPHSNSPCITDDELMDEALVGPGK
Length1610
PositionMiddle
OrganismHeliothis virescens (Tobacco budworm moth)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Lepidoptera> Glossata> Ditrysia> Noctuoidea> Noctuidae> Heliothinae> Heliothis.
Aromaticity0.04
Grand average of hydropathy-0.589
Instability index58.45
Isoelectric point9.19
Molecular weight172660.48
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15342
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     414.97|      55|      58|    1094|    1148|       1
---------------------------------------------------------------------------
  760-  804 (49.05/13.19)	................................SEL..RPSRSA..SSLLLDLTE..GKSY..MPSSVSITPIGSTSNT..........P.NA....GT..G.S
  805-  863 (44.30/11.13)	SI............................tsMLC..LDRRPG..IEII..PIT..AAAPAALPSSITITPITSSQMKT..LDDrirsE.KK....SSRSG.E
  909-  944 (37.19/ 8.05)	.......................................RATS..PNSLIRKFS..PSPTHGRSVSIT.KS.................P.SP....STVKG.M
  945- 1007 (47.18/12.38)	GK.............................pSGT..SSHHSSprHSPVQNSPKhlSGYSSPKNHSISSPKHSSSGSGKpsMSA....L.KS....ATSGSpS
 1008- 1062 (39.44/ 9.03)	GK....................sgttgydltkKLS..KDSYGS...SSMTSRDK..EKKH....SSLSF.SSSDRSSPK..LKN....PiKL....K......
 1063- 1146 (60.81/18.29)	.QleitpvscdspvteplisppnievnksnapSQA..RNRKGS..LSAVIDKLK..SAQHCGTDSEISAKSSSSSSSTK..FSD....P.KA....STAGG.S
 1147- 1196 (53.99/15.33)	GK.............................lSDS..KNQEYM..VKPSSDGMK..I.....TINKTRTKDSSSSSS.K..LNY....S.SS....SSKQS.S
 1197- 1256 (48.96/13.15)	PQ..........................ltppSQGspKTHTGL..KPGVISGPA..SKK...TQAMQSSKSGSVTSGS....TP....P.KAnmspSDSSG.S
 1291- 1341 (34.05/ 6.69)	PK...............ssstdlakiirdrerEKA..RTK....................LMTNSE...KSIFSSKSER..HSS....P.SG....SRDEI.D
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     226.64|      57|      58|     107|     163|       2
---------------------------------------------------------------------------
   61-  104 (57.67/32.36)	........SADRMILKKCLDS........LQHCIKVSSlQSLIERLECLSR..QLG.LKFVVG
  107-  163 (94.82/58.05)	GVNLF..ISSDMFYLEILVESSGSVKDVKIHHEGKIEQ.QSCEELVSCISR..GDF.ADFTAQ
  166-  224 (74.15/43.76)	GLTAVyqLSAEKKVTYASIPVTGEVRRVKCKAFSAL...QSLEEDL.CTMRqlQSFiKDPWAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     195.11|      55|      59|     629|     686|       3
---------------------------------------------------------------------------
  592-  625 (39.40/19.10)	.............HSRALYPSSVNHPHQG..........................GAYLSEQQHHLSAmcqDS
  629-  686 (90.69/65.01)	TKPQTEERKSkkrKSDDVWSSSQKKGKQGI.TEMMDS...........DSDSDNSDEYVNEDENTINS...NS
  687-  744 (65.01/38.72)	TNDDMEGRES.........SVSQNEFTSDMeLSAMDAtdalggqdnrtSSDMDNSND...GDVDDIIR...NS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     109.59|      25|      58|    1521|    1545|       4
---------------------------------------------------------------------------
 1521- 1545 (40.84/21.12)	KPPA.SGAVARS.GATTPQEAAEMLLD
 1551- 1573 (34.44/16.53)	GSKV.SGMVAVR..PVYPSSPA.LALQ
 1576- 1602 (34.31/16.44)	KSPApSPLVAPSpHSNSPCITDDELMD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     180.30|      44|      58|     288|     331|       5
---------------------------------------------------------------------------
  229-  269 (54.11/30.58)	.PIG....FLQKRRGGHAMRLTYFVSPYELLDKDK.GltPL....TAELLT
  288-  331 (74.13/44.80)	TPIGHSATVLLEGSTPNKLQLSPIISGGQRSGKGN.G..PV....YAQLVP
  349-  391 (52.06/29.13)	TPLCAGLAKLIHATTEVE......VAGDWANAKPMlG..LVaqhaYNKLTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      93.45|      17|      17|    1392|    1408|       6
---------------------------------------------------------------------------
 1354- 1370 (25.25/15.60)	LVEGLIKP...LDTSKFQIP
 1372- 1387 (18.75/ 9.26)	LKNQNTPD...KNSPAAQY.
 1392- 1408 (29.70/19.96)	LVNDFART...LEQSKYQFP
 1410- 1427 (19.75/10.23)	FDNPGARTadsIQKSAY..P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.78|      15|      16|    1267|    1281|       7
---------------------------------------------------------------------------
 1267- 1281 (25.66/10.70)	SKSSSAS..SAGINLSK
 1284- 1300 (21.12/ 7.35)	SKSSSGSpkSSSTDLAK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15342 with Med1 domain of Kingdom Metazoa
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