<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15335

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAPVPLEGHQTPVTNNIPQEGNRGGSISLGMLIDFIIQRTYHELTVLAELLPRKTDMERKIEIYNFSARTRQLYVRLLALVKWANSASKVDKSAHIMAFLDKQSLLFVDTADMLARMARETLVHARLPNFHIPAAVEVLTTGTYSRLPACIRERIVPPDPITPAEKRSTLQRLNQVIQHRLVTGNLLPQMRNLKIEAGRVTFLVEQEFSVSLTVMGDGPTVPWRLLELEILVSDRETGDGKALVHPLQTRYVHQVVQSRLAESSNPLSEVYHILHYFCQSLQLEVLYSQTLRLIRDRLDDHIHVDEYTPGKCLSVSYWRELTNKDPRSELGYKLTVQVDQHDPARPLAIVHIPSLGSKESEIADRAIRSDQLSMECLLVHTIYVRTRSRLLDLKQELQTMLKDVECTLAGSPAILSVPILQPCLRAEHLLVTVDTHTGMLQCHVPQYEVPLIPELTTALNGDHSRLPTLISELRFWITQRRCEKTLQHLPATSHERLPVLLHPDHPISKISRHRMFIQLHRHPTVILIVAFKEKETSPCEIECSFYLAVVKHSSIEDDPHDDSIETEIPKMYLKVQSLIEFDTFVITHGPFTSVDNETPETSSLKRRSTGPSGRSDSSATLQNRRSKQPAYFIPELAHVVALCDERIPFVTLAQELTRRDIAHQGLQVEANATALVLKLVQLPAPSAGINTSCAWYALLKRLLSVSIRVQGKGMAKTWMAEFVFYGSPLSSSHPKEQGLRRPVYFQYEMGTADTISRTVDAILNDWAQIVHLYLIVHDLAEYFKMEKYNLRNMVTIKLYNYSKLVLTYGPNRGATVTVQWSTNDKAFKLIFGKSPTSTITNAHSIMKEQLEAHLNRHRNLAQLIHILHETLQPLTSISKLPIIPQLCVYNSRPQVPVQTFTIMPQCVTLVRIAYQGMYCLELRLRGSGLVSLRDGAYSRFDRSYVVDEFTPTQGLKAFLSKYVDESAVSRRRSQSEDDNPPSPVTMDSDGGSGSGNVGFLSHHRSGPQSPAQQRDGLRFHPPLTPPSGSNPHTPASPHTANISQTNQHQSFGSSPATSFNLASPPSLPPNTPNMLPHPSPGSGLVANSPLNPMHVPSPAGLMPTSSPGPCSNVQVGHSPAGSFMQTGHIDGSPFPSSQSMASPAASNWPGSPSVPRPSPARPTQSPGHALHSPQASDHKTGTHISRVLPQRSWAGAVPTLLTHEALELLCCPSPHPSGLPGPDLSPLERFLGCIYMRRQFQRFIQTDECLTAVNSTEPGVVHFKVESLQCRVGLNPQHLQSLHIKVQPLPDHKDQWTLEELQIIEKFFDTRAAIPPYKPNTLSGFGRMLNVPFNVLKDFVQIMKLELVPGLAQQQQLKWNVQWCLRIPPSGTPIVPTGMAAILVCRNKILFFLQITRIGLPYQGETPSLVLPLVYDVSTNLTQLAEKRDPSPASAMAAASLQLKRFAEYGANQSECSLFPAVRDLLANLTLPSDPPVMSQVPPAGGTPTQQIQSPAMQLHSPMAGNQGPPQAPYGIQGMPPMGIMGGPPQ
Length1530
PositionTail
OrganismApis cerana cerana (Oriental honeybee)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Apoidea> Apidae> Apis.
Aromaticity0.06
Grand average of hydropathy-0.237
Instability index59.97
Isoelectric point8.48
Molecular weight169978.29
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15335
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     500.70|      75|      76|    1022|    1096|       1
---------------------------------------------------------------------------
  951- 1024 (50.28/18.61)	PTQGlkaflskyvdesavsrrrsqSED.......DNPPSP..VTmdsdggsgsGNV..GFLSHHRSGPQS.......PA......................................QQRDGL.R....FHP........................P................LT
 1025- 1102 (133.19/62.81)	PPSG....................SNP.......HTPASP..HT.........ANI..SQTNQHQSFGSS.......PA..TSFNLASPP........................SLPPNTPNM.L....PHPS..PGSGLVA...NSPLNPMHVPsP..............agLM
 1103- 1171 (71.37/29.86)	PTSS....................PGPcsnvqvgHSPAGSfmQT.........GHIdgSPFPSSQSM.AS.......PA..AS.NWPGSP........................SVPRPSPAR......PTQS..PGHAL............H......................
 1173- 1245 (46.40/16.55)	.......................................P..QA.........SD...HKTGTHIS.RVL.......PQ..RSWAGAVPT........................LLTHEALEL.LccpsPHPSglPGPDL......SPL........erflgciymrrqfqrfIQ
 1246- 1334 (56.33/21.84)	TDEC....................LTA.......VNSTEP..GV.........VHF..KVESLQCRVGLN.......PQhlQSLHIKVQPlpdhkdqwtleelqiiekffdtraAIPPYKPNT.L..........SGFGRML...NVPFN.........................
 1368- 1422 (66.99/27.52)	PPSG....................T.P.......IVP.TG..MA.........AIL..VCRNKILFF..L.......QI..TRIGL..P..........................YQGETPSLvL....PLVY..DVS................T.N................LT
 1423- 1502 (76.14/32.39)	QLAE....................KRD.......PSPASA..MA.........AAS..LQLKRFAEYGANqsecslfPA..VR.DLLANL........................TLPSDPPVM.S....QVP...PAGGTPTqqiQSPAMQLHSP....................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     177.45|      54|      76|     387|     443|       2
---------------------------------------------------------------------------
  387-  443 (87.51/55.40)	RSRLLDLKQELQTMLKDVEC..TLAGSPAI..LSVPILqpcLRAEHLLVTVDTHTGMLQCH
  463-  520 (89.95/48.85)	HSRLPTLISELRFWITQRRCekTLQHLPATshERLPVL...LHPDHPISKISRHRMFIQLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.78|      16|      18|     872|     888|       3
---------------------------------------------------------------------------
  872-  888 (25.21/18.31)	QPLTSISKLPIIPQlCV
  892-  907 (31.57/18.68)	RPQVPVQTFTIMPQ.CV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.68|      12|      24|     143|     154|       4
---------------------------------------------------------------------------
  143-  154 (22.50/12.97)	TYSRLPACIRER
  169-  180 (21.19/11.79)	TLQRLNQVIQHR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      79.88|      16|      20|     203|     218|      10
---------------------------------------------------------------------------
  203-  218 (27.76/17.34)	LVEQEFSVSLTVMGDG
  225-  240 (26.51/16.23)	LLELEILVSDRETGDG
  698-  713 (25.61/15.44)	LLKRLLSVSIRVQGKG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15335 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PSDPPVMSQVPPAGGTPTQQIQSPAMQLHSPMAGNQGPPQAPYGIQGMPPMGIMGGPPQ
2) SAVSRRRSQSEDDNPPSPVTMDSDGGSGSGNVGFLSHHRSGPQSPAQQRDGLRFHPPLTPPSGSNPHTPASPHTANISQTNQHQSFGSSPATSFNLASPPSLPPNTPNMLPHPSPGSGLVANSPLNPMHVPSPAGLMPTSSPGPCSNVQVGHSPAGSFMQTGHIDGSPFPSSQSMASPAASNWPGSPSVPRPSPARPTQSPGHALHSPQASDHKTGTHISRVLP
1472
966
1530
1189










Molecular Recognition Features






MoRF SequenceStartStop




NANANA