Description | Mediator of RNA polymerase II transcription subunit 19 |
Sequence | MPQRDKRSWAPTLYTTGLIYIAVQVAILSFLSSYYNFGIFNATSWALNALDECEYTHEKLEWLREMWMDAKDKMKLPERKIEEMKAIEAEVPIADGKQILTLEQLGLFDGTRDSKPIYLAILGRVYDVDKGKKHYGKGGGYHFFAGIRDWVSFYEKDYILVGVVTGKYYDSKGKPTAELERVLARIEQANEFRKMKTAEAEVFPPCNSEWHHKNGGRVWCSNKSGGVQREWVGVPRILLDTKTKQKRCACVKNFGPGLSGVEAVQKSTNRGDLDHPHLKILFFSSMGDSPLNAGASSSGQTTGSLRTKISLKAGAATPSYTVVSPFYCMKQEVPPKSNVLGSTDLLGAYDLSSVYSRFCSTKKMREDLASFLPHIYGNFNFAQGQDTSSLRTLYEKPPITGKEISNVSPNHMNAFRLNVGSVDERYRYLFDKRPEGENGLTMEQEKRETTGGRYKHSLDSLEGDEVERKRHKAERKEKKKKKEKRKKDKTKDDIHK |
Length | 496 |
Position | Head |
Organism | Diploscapter pachys |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Rhabditina> Rhabditomorpha> Rhabditoidea> Rhabditidae> Diploscapter. |
Aromaticity | 0.10 |
Grand average of hydropathy | -0.683 |
Instability index | 39.66 |
Isoelectric point | 9.26 |
Molecular weight | 56303.47 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364151 |
GO - Cellular Component | integral component of membrane GO:0016021 IEA:UniProtKB-KW mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP15333 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 96.03| 26| 33| 373| 398| 3 --------------------------------------------------------------------------- 373- 398 (48.17/38.41) PHIYGNFNFAQGQDTSSLRTLYEKPP 409- 434 (47.86/38.11) PNHMNAFRLNVGSVDERYRYLFDKRP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 43.38| 12| 33| 107| 118| 4 --------------------------------------------------------------------------- 107- 118 (22.03/12.26) LFDGTRDSKPIY 143- 154 (21.36/11.69) FFAGIRDWVSFY --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 64.42| 20| 26| 445| 464| 7 --------------------------------------------------------------------------- 445- 464 (33.25/17.39) EKRETTGGRYKHSLDSLEGD 474- 493 (31.17/15.91) ERKEKKKKKEKRKKDKTKDD --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) ERYRYLFD 2) RYKHSLDSLEGDEVERKRHKAERKEKKKKKEKRKKDKTKDDIHK | 424 453 | 431 496 |
© 2021 Shailesh Lab
Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab