<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15316

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMSSDDDWPSQRFRDHVINRLEPELARNRQNAPNLPVPGDARQVEEYVFQKCLSKDEYMRTIAKVINAINCNSKSAAVPPAVIQPFSNSSGTGNSTPLGGPNGSTSVSTPTMKPSVPPDPQPTQARSQVHPNVTTTNSGPTHPNTLPASSMPPQGQTQGGGSVIGAQGSGPYPSGGSMGVNNYSMSTAPPLGQPPPQMGMNSGPAMPQGQSMPPGNYSGYPPHQQMNMNGPPGGHQYGPNATNLKTPKQEPVRSWDNNQQPHYYGSQQGGWGGGPAGGMPPMGAGSGYPPQSMNSTSIGNGSHNGGSSQPPSVLEALITHPQYPMHPNSRHNMPMGPMNGAPGSGPGMAKSGPPMGGQPTSGSNIQVTPGLVEMTPQEQQTYQRKLHELRPHCDNLRLRSQQCRIDGNHEAAHKLEVMLAVLEGRRVVTLEYLSHLESWIYKKQEFLAGASQLMQNGGLHAGGQGAAAGNASNSMMNPAMGDMNNSVPQGMSSNIPPTPHMSAPNNPYGTQGQPPMSHGGYMHSQQMPPMWNQGPHQQRMMPQDMMGGAPMGGVSSAAGSMHYQRDDHHGHRAAPYPSPQMRQQMRQHSGSSGQPIRDHRGSVSSMSSMSGGAPTPTQSMATAQPPSIPGVDEIYNIEDFLPTPIESGSLQSNMQSGMHGQMSNAARPILNEAARREFSAMTDRFDADLQNIESMDAQSVIVKCKLRSHTVPVLRVIVPAMYPNVNASIDRGTLDLDAYLYDDLQNQVHDRLIRVEQPTITNLLNTWEQTVTQFYQSQGGNPLDTFDEIFRNYDSF
Length795
PositionTail
OrganismDiploscapter pachys
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Rhabditina> Rhabditomorpha> Rhabditoidea> Rhabditidae> Diploscapter.
Aromaticity0.05
Grand average of hydropathy-0.751
Instability index64.71
Isoelectric point6.48
Molecular weight85331.17
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15316
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     494.08|      58|      66|     192|     249|       1
---------------------------------------------------------------------------
  116-  188 (62.75/13.39)	PPD.....PQptqarsqvhpnvTTTN....SGPTHPNtlpASSMPPqGQTQG...GG............SVIG......AQG....SGPyP.S..GGSMGVNNYS.MST...AP
  192-  249 (121.63/33.20)	QPP.....PQ............MGMN....SGPAMPQ...GQSMPP.GNYSG...YP............PHQQ......MNM....NGP.P.G..GHQYGPNATN.LKTPK.QE
  258-  314 (62.37/13.26)	QQPhyygsQQ............GGWG....GGPA......G.GMPPmGAGSG...YP............P.QS......MNStsigNGS.H.N..GGSSQP........PSvLE
  319-  356 (61.35/12.92)	HPQ.....YP............MHPN....SRH.........NMPM.G................................PM....NGA.P.G..S...GPGMAK.SGPPM.GG
  451-  506 (66.80/14.75)	QLM.....QN............GGLH....AG........GQGAAA.GNASNsmmNP............AMGD......MNN....SVP.Q.G..MSSNIPPTPH.MSAPN.NP
  512-  568 (75.02/17.52)	QPP.....................MS....HGGYM.H...SQQMPP.MWNQG.................PHQQrmmpqdM.M....GGA.PmG..GVSSAAGSMH.YQRDD.HH
  575-  643 (44.15/ 7.13)	YPS.....PQ............MRQQmrqhSGSS......GQ..PI.RDHRG...SVssmssmsggaptPTQS......MAT....AQP.P.SipGVDEIYNIEDfLPTP....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.47|      16|      16|     753|     768|       2
---------------------------------------------------------------------------
  753-  768 (28.19/15.02)	RVEQPTITNLLNTWEQ
  772-  787 (29.28/15.87)	QFYQSQGGNPLDTFDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.87|      27|      54|     664|     690|       4
---------------------------------------------------------------------------
  664-  690 (46.70/30.04)	AARPILN...EAARREFSAMTDR........FDADLQN
  708-  745 (37.16/22.49)	HTVPVLRvivPAMYPNVNASIDRgtldldayLYDDLQN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15316 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAVPPAVIQPFSNSSGTGNSTPLGGPNGSTSVSTPTMKPSVPPDPQPTQARSQVHPNVTTTNSGPTHPNTLPASSMPPQGQTQGGGSVIGAQGSGPYPSGGSMGVNNYSMSTAPPLGQPPPQMGMNSGPAMPQGQSMPPGNYSGYPPHQQMNMNGPPGGHQYGPNATNLKTPKQEPVRSWDNNQQPHYYGSQQGGWGGGPAGGMPPMGAGSGYPPQSMNSTSIGNGSHNGGSSQPPSVLEALITHPQYPMHPNSRHNMPMGPMNGAPGSGPGMAKSGPPMGGQPTSGSNIQVTPGLVEMTPQEQQTYQRKLHELRPHCDNLRLRSQQCRIDGNHE
2) MSSDDDWPSQRFRDHVINRLEPELARNRQNAPNLPVPGDARQVEE
3) SQLMQNGGLHAGGQGAAAGNASNSMMNPAMGDMNNSVPQGMSSNIPPTPHMSAPNNPYGTQGQPPMSHGGYMHSQQMPPMWNQGPHQQRMMPQDMMGGAPMGGVSSAAGSMHYQRDDHHGHRAAPYPSPQMRQQMRQHSGSSGQPIRDHRGSVSSMSSMSGGAPTPTQSMATAQPPSIP
75
1
450
409
45
628










Molecular Recognition Features






MoRF SequenceStartStop




NANANA