<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15313

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMPPQGQTQGGPVIGAQGSGSYPSGGSMGVNNYSMSTAPPLGQPPPQMSMNSGPAMPQGQSMPPGNYSGYPPHQQMNMNGPPGGHQYGPNATNLKTPKQEPVRSWDNNQQPHYYGSQQGGWGGGPAGGIPPMGAGSGYPPQSMNPTSIGNGSHNGGSSQPPSVLEALITHPQYPMHPNSRHNMPMGPMNGAPGSGPGMAKSGPPMGGQPTSGSNIQVTPGLVEMTPQEQQTYQRKLHELRPHCDNLRLRSQQCRIDGNHEAAHKLEVMLAVLEGRRVVTLEYLSHLESWIYKKQEFLAGASQLMQNGGLHAGGQGAAAGNASNSMMNPAMGDMNNSVPQGMPSNIPPTPHMSAPNNPYGTQGQPPMSHGGYMHSQQMPPMWNQGSHQQRMMPQDMMGGAPMGGVPSSAAGSMHYQRDDHHGHRAAPYPSPQMRQQMRQHSGSSGQPIRDHRGSVSSMSSMSGGAPTPTQSMATAQPPSIPGVDEIYNIEDFLPTPIESGGLQSSMQSGMHGQMSNATRPILNEAARREFSAMSDRFDADLQNVEFMDAQSVIVKSKLRSHTVPVLRVIVPAMYPNVNASIDRGTLDLDAYLYDDLQNQVHDRLSRVEQPTITNLLNTWEQTVTQFYQSQGGNPLDTFDEIFRNYDSF
Length646
PositionTail
OrganismDiploscapter pachys
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Rhabditina> Rhabditomorpha> Rhabditoidea> Rhabditidae> Diploscapter.
Aromaticity0.06
Grand average of hydropathy-0.757
Instability index68.81
Isoelectric point6.35
Molecular weight69372.61
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15313
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     244.03|      32|      33|     129|     160|       1
---------------------------------------------------------------------------
   13-   45 (35.37/ 7.16)	I.GA.Q............GS.......G.SYPSGGSMGVnnysmstaPPLGQP...PP
   46-   71 (39.77/ 9.17)	QmSM.N.............S.......GpAMPQGQSMPP...........GNYSGYPP
   89-  139 (38.59/ 8.63)	N.AT.NlKTpkqepvrSWDNnqqphyyG.SQQGGWGGGP....aggiPPMGAGSGYPP
  140-  173 (44.05/11.13)	Q.SM.N.PT.......SIGN.......G.SHNGGSSQPP.....svlEALITHPQYP.
  322-  353 (38.89/ 8.77)	N.SMmN.PA......mGDMN.......N.SVPQGMPSNI........PP..TPHMSAP
  374-  400 (47.37/12.65)	Q.QM.P.PM........WNQ.......G.SHQQ.RMMPQ........DMMG...GAPM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     142.69|      42|      47|     418|     461|       3
---------------------------------------------------------------------------
  418-  461 (71.62/33.80)	HHGHRAAPyPSPQMRQQMRQHSGSSGQPIrDHRGSVSSM.SSMSG
  468-  510 (71.07/27.18)	QSMATAQP.PSIPGVDEIYNIEDFLPTPI.ESGGLQSSMqSGMHG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      78.75|      14|     121|      75|      88|       4
---------------------------------------------------------------------------
   75-   88 (31.44/14.12)	MNMNGPPGGHQYGP
  197-  208 (24.37/ 9.04)	MAKSGPPMGGQ..P
  212-  225 (22.94/ 8.02)	SNIQVTPGLVEMTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.12|      27|      54|     515|     541|       5
---------------------------------------------------------------------------
  515-  541 (47.40/28.45)	ATRPILN...EAARREFSAMSDR........FDADLQN
  559-  596 (37.72/21.29)	HTVPVLRvivPAMYPNVNASIDRgtldldayLYDDLQN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.77|      13|      18|     607|     619|       6
---------------------------------------------------------------------------
  607-  619 (24.04/15.37)	QPTITNLLNTWEQ
  626-  638 (23.73/15.06)	QSQGGNPLDTFDE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15313 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IESGGLQSSMQSGMHGQMSNATRPILNEAARRE
2) MPPQGQTQGGPVIGAQGSGSYPSGGSMGVNNYSMSTAPPLGQPPPQMSMNSGPAMPQGQSMPPGNYSGYPPHQQMNMNGPPGGHQYGPNATNLKTPKQEPVRSWDNNQQPHYYGSQQGGWGGGPAGGIPPMGAGSGYPPQSMNPTSIGNGSHNGGSSQPPSVLEALITHPQYPMHPNSRHNMPMGPMNGAPGSGPGMAKSGPPMGGQPTSGSNIQVTPGLVEMTPQEQQTYQRKLHELRPHCDNLRLRSQQCRIDGNHE
3) SQLMQNGGLHAGGQGAAAGNASNSMMNPAMGDMNNSVPQGMPSNIPPTPHMSAPNNPYGTQGQPPMSHGGYMHSQQMPPMWNQGSHQQRMMPQDMMGGAPMGGVPSSAAGSMHYQRDDHHGHRAAPYPSPQMRQQMRQHSGSSGQPIRDHRGSVSSMSSMSGGAPTPTQSMATAQPPSIP
495
1
300
527
259
479










Molecular Recognition Features






MoRF SequenceStartStop




NANANA