<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15312

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMPPGNYSGYPPHQQMNMNGPPGGHQYGPNATNLKTPKQEPVRSWDNNQQPHYYGSQQGGWGGGPAGGIPPMGAGSGYPPQSMNPTSIGNGSHNGGSSQPPSVLEALITHPQYPMHPNSRHNMPMGPMNGAPGSGPGMAKSGPPMGGQPTSGSNIQVTPGLVEMTPQEQQTYQRKLHELRPHCDNLRLRSQQCRIDGNHEAAHKLEVMLAVLEGRRVVTLEYLSHLESWIYKKQEFLAGASQLMQNGGLHAGGQGAAAGNASNSMMNPAMGDMNNSVPQGMPSNIPPTPHMSAPNNPYGTQGQPPMSHGGYMHSQQMPPMWNQGSHQQRMMPQDMMGGAPMGGVPSSAAGSMHYQRDDHHGHRAAPYPSPQMRQQMRQHSGSSGQPIRDHRGSVSSMSSMSGGAPTPTQSMATAQPPSIPGVDEIYNIEDFLPTPIESGGLQSSMQSGMHGQMSNATRPILNEAARREFSAMSDRFDADLQNVEFMDAQSVIVKSKLRSHTVPVLRVIVPAMYPNVNASIDRGTLDLDAYLYDDLQNQVHDRLSRVEQPTITNLLNTWEQTVTQFYQSQGGNPLDTFDEIFRNYDSF
Length586
PositionTail
OrganismDiploscapter pachys
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Rhabditina> Rhabditomorpha> Rhabditoidea> Rhabditidae> Diploscapter.
Aromaticity0.06
Grand average of hydropathy-0.768
Instability index66.78
Isoelectric point6.35
Molecular weight63515.15
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15312
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     452.18|      57|      57|     288|     344|       1
---------------------------------------------------------------------------
   26-   69 (59.36/14.66)	...YGPNaTNL.KTPKQEP.VR..SWDNNQ....Q.PHYY....GSQQGG..........W......GGGP.....AGGI.P
   84-  131 (67.80/17.75)	P.TSIGN.GSHnGGSSQPPsVLEALITHPQ....Y..PMHPN..SRHN.............MP...MG..P.....MNGA.P
  135-  175 (36.45/ 6.28)	PGMAKSG.PPM.G..GQP...TSGSNIQVTpglvEMTPQ.EQ..QTYQRK..........L.....................
  180-  215 (49.53/11.06)	PHC...D.N...............LRLRSQ....QCRI...D..GNHEAA..........HKLEVML..AV.....LEGR.R
  241-  281 (59.69/14.78)	QLMQNGG.LHA.GGQGAAA.GNASNSMMNP....AMGDMNN.....S..............VPQGM...............P
  288-  344 (122.04/37.61)	PHMSAPN.NPY.GTQGQPP.MSHGGYMHSQ....QMPPMWNQ..GSHQQR..........MMPQDMMGGAP.....MGGV.P
  351-  415 (57.29/13.90)	MHYQR.D.DHH.GHRAAP.......Y.PSP....QMRQQMRQhsGSSGQPirdhrgsvssM..SSMSGGAPtptqsMATAqP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.89|      14|      65|       2|      16|       2
---------------------------------------------------------------------------
    2-   16 (29.28/14.60)	PPGNYSGYPPhQQMN
   70-   83 (31.61/11.84)	PMGAGSGYPP.QSMN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     189.91|      50|      53|     430|     481|       3
---------------------------------------------------------------------------
  430-  481 (82.17/56.13)	FLPTpiESGGLQSSMQSGMHGQMSNATRP....ILN...EAARREFSAMS.....DRFDADLQN
  484-  528 (62.44/36.06)	FMDA..QSVIVKSKLRS..H......TVP....VLRvivPAMYPNVNASI.....DRGTLDLDA
  530-  582 (45.30/23.55)	..........LYDDLQNQVHDRLSRVEQPtitnLLN.twEQTVTQFYQSQggnplDTFDEIFRN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15312 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IESGGLQSSMQSGMHGQMSNATRPILNEAARRE
2) MPPGNYSGYPPHQQMNMNGPPGGHQYGPNATNLKTPKQEPVRSWDNNQQPHYYGSQQGGWGGGPAGGIPPMGAGSGYPPQSMNPTSIGNGSHNGGSSQPPSVLEALITHPQYPMHPNSRHNMPMGPMNGAPGSGPGMAKSGPPMGGQPTSGSNIQVTPGLVEMTPQEQQTYQRKLHELRPHCDNLRLRSQQCRIDGNHE
3) SQLMQNGGLHAGGQGAAAGNASNSMMNPAMGDMNNSVPQGMPSNIPPTPHMSAPNNPYGTQGQPPMSHGGYMHSQQMPPMWNQGSHQQRMMPQDMMGGAPMGGVPSSAAGSMHYQRDDHHGHRAAPYPSPQMRQQMRQHSGSSGQPIRDHRGSVSSMSSMSGGAPTPTQSMATAQPPSIP
435
1
240
467
199
419










Molecular Recognition Features






MoRF SequenceStartStop




NANANA